Exposure to diagnostic radiation and risk of breast cancer among carriers of BRCA1/2 mutations: Retrospective cohort study (GENE-RAD-RISK)

Anouk Pijpe; Nadine Andrieu; Douglas F. Easton; Ausrele Kesminiene; Elisabeth Cardis; Catherine Noguès; Marion Gauthier-Villars; Christine Lasset; Jean Pierre Fricker; Susan Peock; Debra Frost; D. Gareth Evans; Rosalind A. Eeles; Joan Paterson Clinical; Peggy Manders; Christi J. Van Asperen; Margreet G E M Ausems; Hanne Meijers-Heijboer; Isabelle Thierry-Chef; Michael Hauptmann; David Goldgar; Matti A. Rookus; Flora E. Van Leeuwen

doi:10.1136/bmj.e5660

Exposure to diagnostic radiation and risk of breast cancer among carriers of BRCA1/2 mutations: Retrospective cohort study (GENE-RAD-RISK)

Anouk Pijpe
, Nadine Andrieu
, Douglas F. Easton
, Ausrele Kesminiene
, Elisabeth Cardis
, Catherine Noguès
, Marion Gauthier-Villars
, Christine Lasset
, Jean Pierre Fricker
, Susan Peock
, Debra Frost
, D. Gareth Evans
, Rosalind A. Eeles
, Joan Paterson Clinical
, Peggy Manders
, Christi J. Van Asperen
, Margreet G E M Ausems
, Hanne Meijers-Heijboer
, Isabelle Thierry-Chef
, Michael Hauptmann

David Goldgar, Matti A. Rookus, Flora E. Van Leeuwen

Research output: Contribution to journal › Article › peer-review

Abstract

Objective: To estimate the risk of breast cancer associated with diagnostic radiation in carriers of BRCA1/2 mutations. Design: Retrospective cohort study (GENE-RAD-RISK). Setting: Three nationwide studies (GENEPSO, EMBRACE, HEBON) in France, United Kingdom, and the Netherlands, Participants: 1993 female carriers of BRCA1/2 mutations recruited in 2006-09. Main outcome measure: Risk of breast cancer estimated with a weighted Cox proportional hazards model with a time dependent individually estimated cumulative breast dose, based on nominal estimates of organ dose and frequency of self reported diagnostic procedures. To correct for potential survival bias, the analysis excluded carriers who were diagnosed more than five years before completion of the study questionnaire. Results: In carriers of BRCA1/2 mutations any exposure to diagnostic radiation before the age of 30 was associated with an increased risk of breast cancer (hazard ratio 1.90, 95% confidence interval 1.20 to 3.00), with a dose-response pattern. The risks by quarter of estimated cumulative dose

Original language	English
Article number	e5660
Journal	Bmj
Volume	345
Issue number	7878
DOIs	https://doi.org/10.1136/bmj.e5660
Publication status	Published - 13 Oct 2012

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SDG 3 Good Health and Well-being

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Pijpe, A., Andrieu, N., Easton, D. F., Kesminiene, A., Cardis, E., Noguès, C., Gauthier-Villars, M., Lasset, C., Fricker, J. P., Peock, S., Frost, D., Evans, D. G., Eeles, R. A., Clinical, J. P., Manders, P., Van Asperen, C. J., Ausems, M. G. E. M., Meijers-Heijboer, H., Thierry-Chef, I., ... Van Leeuwen, F. E. (2012). Exposure to diagnostic radiation and risk of breast cancer among carriers of BRCA1/2 mutations: Retrospective cohort study (GENE-RAD-RISK). Bmj, 345(7878), Article e5660. https://doi.org/10.1136/bmj.e5660

@article{825a245b943149a89e531e3edf04b3cc,

title = "Exposure to diagnostic radiation and risk of breast cancer among carriers of BRCA1/2 mutations: Retrospective cohort study (GENE-RAD-RISK)",

abstract = "Objective: To estimate the risk of breast cancer associated with diagnostic radiation in carriers of BRCA1/2 mutations. Design: Retrospective cohort study (GENE-RAD-RISK). Setting: Three nationwide studies (GENEPSO, EMBRACE, HEBON) in France, United Kingdom, and the Netherlands, Participants: 1993 female carriers of BRCA1/2 mutations recruited in 2006-09. Main outcome measure: Risk of breast cancer estimated with a weighted Cox proportional hazards model with a time dependent individually estimated cumulative breast dose, based on nominal estimates of organ dose and frequency of self reported diagnostic procedures. To correct for potential survival bias, the analysis excluded carriers who were diagnosed more than five years before completion of the study questionnaire. Results: In carriers of BRCA1/2 mutations any exposure to diagnostic radiation before the age of 30 was associated with an increased risk of breast cancer (hazard ratio 1.90, 95\% confidence interval 1.20 to 3.00), with a dose-response pattern. The risks by quarter of estimated cumulative dose",

author = "Anouk Pijpe and Nadine Andrieu and Easton, \{Douglas F.\} and Ausrele Kesminiene and Elisabeth Cardis and Catherine Nogu{\`e}s and Marion Gauthier-Villars and Christine Lasset and Fricker, \{Jean Pierre\} and Susan Peock and Debra Frost and Evans, \{D. Gareth\} and Eeles, \{Rosalind A.\} and Clinical, \{Joan Paterson\} and Peggy Manders and \{Van Asperen\}, \{Christi J.\} and Ausems, \{Margreet G E M\} and Hanne Meijers-Heijboer and Isabelle Thierry-Chef and Michael Hauptmann and David Goldgar and Rookus, \{Matti A.\} and \{Van Leeuwen\}, \{Flora E.\}",

note = "C1287/A8874, Cancer Research UK, United KingdomC5047/A8385, Cancer Research UK, United KingdomR01 CA142657, NCI NIH HHS, United States",

year = "2012",

month = oct,

day = "13",

doi = "10.1136/bmj.e5660",

language = "English",

volume = "345",

journal = "Bmj",

issn = "0959-535X",

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}

Pijpe, A, Andrieu, N, Easton, DF, Kesminiene, A, Cardis, E, Noguès, C, Gauthier-Villars, M, Lasset, C, Fricker, JP, Peock, S, Frost, D, Evans, DG, Eeles, RA, Clinical, JP, Manders, P, Van Asperen, CJ, Ausems, MGEM, Meijers-Heijboer, H, Thierry-Chef, I, Hauptmann, M, Goldgar, D, Rookus, MA & Van Leeuwen, FE 2012, 'Exposure to diagnostic radiation and risk of breast cancer among carriers of BRCA1/2 mutations: Retrospective cohort study (GENE-RAD-RISK)', Bmj, vol. 345, no. 7878, e5660. https://doi.org/10.1136/bmj.e5660

TY - JOUR

T1 - Exposure to diagnostic radiation and risk of breast cancer among carriers of BRCA1/2 mutations: Retrospective cohort study (GENE-RAD-RISK)

AU - Pijpe, Anouk

AU - Andrieu, Nadine

AU - Easton, Douglas F.

AU - Kesminiene, Ausrele

AU - Cardis, Elisabeth

AU - Noguès, Catherine

AU - Gauthier-Villars, Marion

AU - Lasset, Christine

AU - Fricker, Jean Pierre

AU - Peock, Susan

AU - Frost, Debra

AU - Evans, D. Gareth

AU - Eeles, Rosalind A.

AU - Clinical, Joan Paterson

AU - Manders, Peggy

AU - Van Asperen, Christi J.

AU - Ausems, Margreet G E M

AU - Meijers-Heijboer, Hanne

AU - Thierry-Chef, Isabelle

AU - Hauptmann, Michael

AU - Goldgar, David

AU - Rookus, Matti A.

AU - Van Leeuwen, Flora E.

N1 - C1287/A8874, Cancer Research UK, United KingdomC5047/A8385, Cancer Research UK, United KingdomR01 CA142657, NCI NIH HHS, United States

PY - 2012/10/13

Y1 - 2012/10/13

N2 - Objective: To estimate the risk of breast cancer associated with diagnostic radiation in carriers of BRCA1/2 mutations. Design: Retrospective cohort study (GENE-RAD-RISK). Setting: Three nationwide studies (GENEPSO, EMBRACE, HEBON) in France, United Kingdom, and the Netherlands, Participants: 1993 female carriers of BRCA1/2 mutations recruited in 2006-09. Main outcome measure: Risk of breast cancer estimated with a weighted Cox proportional hazards model with a time dependent individually estimated cumulative breast dose, based on nominal estimates of organ dose and frequency of self reported diagnostic procedures. To correct for potential survival bias, the analysis excluded carriers who were diagnosed more than five years before completion of the study questionnaire. Results: In carriers of BRCA1/2 mutations any exposure to diagnostic radiation before the age of 30 was associated with an increased risk of breast cancer (hazard ratio 1.90, 95% confidence interval 1.20 to 3.00), with a dose-response pattern. The risks by quarter of estimated cumulative dose

AB - Objective: To estimate the risk of breast cancer associated with diagnostic radiation in carriers of BRCA1/2 mutations. Design: Retrospective cohort study (GENE-RAD-RISK). Setting: Three nationwide studies (GENEPSO, EMBRACE, HEBON) in France, United Kingdom, and the Netherlands, Participants: 1993 female carriers of BRCA1/2 mutations recruited in 2006-09. Main outcome measure: Risk of breast cancer estimated with a weighted Cox proportional hazards model with a time dependent individually estimated cumulative breast dose, based on nominal estimates of organ dose and frequency of self reported diagnostic procedures. To correct for potential survival bias, the analysis excluded carriers who were diagnosed more than five years before completion of the study questionnaire. Results: In carriers of BRCA1/2 mutations any exposure to diagnostic radiation before the age of 30 was associated with an increased risk of breast cancer (hazard ratio 1.90, 95% confidence interval 1.20 to 3.00), with a dose-response pattern. The risks by quarter of estimated cumulative dose

U2 - 10.1136/bmj.e5660

DO - 10.1136/bmj.e5660

M3 - Article

C2 - 22956590

SN - 0959-535X

VL - 345

JO - Bmj

JF - Bmj

IS - 7878

M1 - e5660

ER -

Exposure to diagnostic radiation and risk of breast cancer among carriers of BRCA1/2 mutations: Retrospective cohort study (GENE-RAD-RISK)

Abstract

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