Expression and characterization of v5 integrin on intestinal macrophages

Ashok K Kumawat, Chen Yu, Elizabeth A Mann, Anika Schridde, Silvia C Finnemann, Allan McI Mowat

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose – The aim of the paper is to contribute to the discussion of treating the concepts of lean and\r\nagile in isolation or combination by presenting an alternative view from complexity thinking on these\r\nconcepts, considering an epistemological approach to this topic.\r\nDesign/methodology/approach – The paper adopts an epistemological approach, using the\r\ncomplexity thinking as the dominant paradigm from which to investigate the concepts and principles\r\nof lean and agile.\r\nFindings – The epistemological approach to the topic clearly reveals the opposition between two\r\nthinking principles: the principle of simplicity and the principle of complexity. Next, the authors\r\nevaluated how the complexity thinking principles of Morin may permit the two different ways of\r\nthinking to be reconciled. They find out that, in an organization, lean and agile are not only inseparable\r\nbut also interdependent.\r\nPractical implications – The paper shows how the concepts of lean and agile can be combined,\r\nwhich may be of help to managers and project leaders to adopt from both practices and tools to\r\nimprove their competitiveness.\r\nOriginality/value – The novelty of this paper is the presentation of an alternative approach to the\r\nconcepts of lean and agile, using an epistemological point-of-view. The paper deepens the\r\nunderstanding of the lean and agile concepts by applying the complexity paradigm as proposed by\r\nEdgar Morin. Furthermore, it proposes self-organizing teams for possible unification of both concepts.
Original languageEnglish
Pages (from-to)1181-1187
Number of pages7
JournalEuropean journal of immunology
Volume48
Issue number7
Early online date20 Apr 2018
DOIs
Publication statusPublished - 1 Jul 2018

Keywords

  • Homeostasis
  • Intestine
  • Macrophage
  • Phagocytosis
  • αvβ5 integrin

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