Expression of glutathione S-transferase (GST) subtypes in resected lung tumours: Relationship to histological type and proliferation indices

T. Hatton, N. Pendleton, R. Barraclough

Research output: Contribution to journalArticlepeer-review

Abstract

Samples from 19 resected lung tumours have been analysed for the levels of GST α, μ and π mRNA and protein. No significant survival disadvantage was found for patients with tumours containing any of the GST subtypes at the levels of either protein or mRNA. Both GST μ and GST π mRNAs were expressed at significantly higher levels in squamous carcinomas than adenocarcinomas but GST α mRNA was not. The significant increases in expression of μ and π GST in squamous relative to adenocarcinomas of the lung is not related to differences in the proliferation rates between these cancers.

Original languageEnglish
Pages (from-to)881-886
Number of pages6
JournalInternational Journal of Oncology
Volume3
Issue number5
DOIs
Publication statusPublished - 1 Jan 1993

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