Expression profile of wild-type ETV6 in childhood acute leukaemia

Naina Patel; Lindsey K. Goff; Taane Clark; Anthony M. Ford; Nicola Foot; Debra Lillington; Sandra Hing; Kathy Pritchard-Jones; Louise K. Jones; Vaskar Saha

doi:10.1046/j.1365-2141.2003.04399.x

Expression profile of wild-type ETV6 in childhood acute leukaemia

Naina Patel, Lindsey K. Goff, Taane Clark, Anthony M. Ford, Nicola Foot, Debra Lillington, Sandra Hing, Kathy Pritchard-Jones, Louise K. Jones, Vaskar Saha

Research output: Contribution to journal › Article › peer-review

Abstract

Comparative expression analysis of wild-type ETV6 in the disease state showed an absence of expression in ETV6-CBFA2 acute lymphoblastic leukaemia (ALL) when compared with non-ETV6-CBFA2 ALL and acute myeloid leukaemia. Fluorescent in-situ hybridization and loss of heterozygosity studies showed that 73% of the ETV 6-CBFA2 samples had a fully or partially deleted second ETV6 allele, explaining the lack of wild-type expression in these patients. Although the second ETV6 allele was identified in the remaining patients, no ETV6 expression was detected. These observations support the hypothesis that loss of ETV6 expression is a critical secondary event for leukaemogenesis in ETV6-CBFA2 ALL.

Original language	English
Pages (from-to)	94-98
Number of pages	4
Journal	British Journal of Haematology
Volume	122
Issue number	1
DOIs	https://doi.org/10.1046/j.1365-2141.2003.04399.x
Publication status	Published - Jul 2003

Keywords

Acute leukaemia
ETV6
ETV6-CBFA2
Gene expression

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1046/j.1365-2141.2003.04399.x

Cite this

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title = "Expression profile of wild-type ETV6 in childhood acute leukaemia",

abstract = "Comparative expression analysis of wild-type ETV6 in the disease state showed an absence of expression in ETV6-CBFA2 acute lymphoblastic leukaemia (ALL) when compared with non-ETV6-CBFA2 ALL and acute myeloid leukaemia. Fluorescent in-situ hybridization and loss of heterozygosity studies showed that 73% of the ETV 6-CBFA2 samples had a fully or partially deleted second ETV6 allele, explaining the lack of wild-type expression in these patients. Although the second ETV6 allele was identified in the remaining patients, no ETV6 expression was detected. These observations support the hypothesis that loss of ETV6 expression is a critical secondary event for leukaemogenesis in ETV6-CBFA2 ALL.",

keywords = "Acute leukaemia, ETV6, ETV6-CBFA2, Gene expression",

author = "Naina Patel and Goff, {Lindsey K.} and Taane Clark and Ford, {Anthony M.} and Nicola Foot and Debra Lillington and Sandra Hing and Kathy Pritchard-Jones and Jones, {Louise K.} and Vaskar Saha",

year = "2003",

month = jul,

doi = "10.1046/j.1365-2141.2003.04399.x",

language = "English",

volume = "122",

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TY - JOUR

T1 - Expression profile of wild-type ETV6 in childhood acute leukaemia

AU - Patel, Naina

AU - Goff, Lindsey K.

AU - Clark, Taane

AU - Ford, Anthony M.

AU - Foot, Nicola

AU - Lillington, Debra

AU - Hing, Sandra

AU - Pritchard-Jones, Kathy

AU - Jones, Louise K.

AU - Saha, Vaskar

PY - 2003/7

Y1 - 2003/7

N2 - Comparative expression analysis of wild-type ETV6 in the disease state showed an absence of expression in ETV6-CBFA2 acute lymphoblastic leukaemia (ALL) when compared with non-ETV6-CBFA2 ALL and acute myeloid leukaemia. Fluorescent in-situ hybridization and loss of heterozygosity studies showed that 73% of the ETV 6-CBFA2 samples had a fully or partially deleted second ETV6 allele, explaining the lack of wild-type expression in these patients. Although the second ETV6 allele was identified in the remaining patients, no ETV6 expression was detected. These observations support the hypothesis that loss of ETV6 expression is a critical secondary event for leukaemogenesis in ETV6-CBFA2 ALL.

AB - Comparative expression analysis of wild-type ETV6 in the disease state showed an absence of expression in ETV6-CBFA2 acute lymphoblastic leukaemia (ALL) when compared with non-ETV6-CBFA2 ALL and acute myeloid leukaemia. Fluorescent in-situ hybridization and loss of heterozygosity studies showed that 73% of the ETV 6-CBFA2 samples had a fully or partially deleted second ETV6 allele, explaining the lack of wild-type expression in these patients. Although the second ETV6 allele was identified in the remaining patients, no ETV6 expression was detected. These observations support the hypothesis that loss of ETV6 expression is a critical secondary event for leukaemogenesis in ETV6-CBFA2 ALL.

KW - Acute leukaemia

KW - ETV6

KW - ETV6-CBFA2

KW - Gene expression

U2 - 10.1046/j.1365-2141.2003.04399.x

DO - 10.1046/j.1365-2141.2003.04399.x

M3 - Article

SN - 0007-1048

VL - 122

SP - 94

EP - 98

JO - British Journal of Haematology

JF - British Journal of Haematology

IS - 1

ER -

Expression profile of wild-type ETV6 in childhood acute leukaemia

Abstract

Keywords

UN SDGs

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