External and internal glucose mass transfers in succinic acid fermentation with stirred bed of immobilized Actinobacillus succinogenes under substrate and product inhibitions

Anca Irina Galaction, Roxana Rotaru, Lenuta Kloetzer, Anestis Vlysidis, Colin Webb, Marius Turnea, Dan Caşcaval

    Research output: Contribution to journalArticlepeer-review

    Abstract

    This paper is dedicated to the study on the external and internal mass transfers of glucose for succinic acid fermentation under substrate and product inhibitions using a bioreactor with stirred bed of immobilized Actinobacillus succinogenes cells. By means of the substrate mass balance for a single particle of biocatalysts, considering the kinetic model adapted for both inhibitory effects, specific mathematical models were developed for describing the profiles of the substrate concentration in the outer and inner regions of biocatalysts and for estimating the substrate mass flows in the liquid boundary layer surrounding the particle and inside the particle. The values of the mass flows were significantly influenced by the internal diffusion velocity and rate of the biochemical reaction of substrate consumption. These cumulated influences led to the appearance of a biological inactive region near the particle center, its magnitude varying from 0 to 5.3% of the overall volume of particles.
    Original languageEnglish
    Pages (from-to)1257-1263
    Number of pages6
    JournalJournal of Microbiology and Biotechnology
    Volume21
    Issue number12
    DOIs
    Publication statusPublished - 12 Oct 2011

    Keywords

    • Actinobacillus succinogenes
    • Immobilized cells
    • Internal diffusion
    • Mass transfer
    • Stirred bed
    • Succinic acid fermentation

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