Externally controllable glycan presentation on nanoparticle surfaces to modulate lectin recognition

Sangho Won; Sarah-Jane Richards; Marc Walker; Matthew I. Gibson

doi:10.1039/c6nh00202a

Externally controllable glycan presentation on nanoparticle surfaces to modulate lectin recognition

Sangho Won, Sarah-Jane Richards, Marc Walker, Matthew I. Gibson

Materials Chemistry

Research output: Contribution to journal › Article › peer-review

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Abstract

Nature dynamically controls carbohydrate expression on cells rather than static presentation. Here we report synthetic glycosylated nanoparticles that contain polymeric ‘gates’ to enable external control (via temperature changes) of glycan surface expression, as an alternative to enzymatic control in nature. This approach offers a new dynamic multivalent scaffold for glycan recognition.

Original language	English
Pages (from-to)	106-109
Number of pages	4
Journal	Nanoscale Horizons
Volume	2
Early online date	14 Dec 2016
DOIs	https://doi.org/10.1039/c6nh00202a
Publication status	Published - 1 Mar 2017

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title = "Externally controllable glycan presentation on nanoparticle surfaces to modulate lectin recognition",

abstract = "Nature dynamically controls carbohydrate expression on cells rather than static presentation. Here we report synthetic glycosylated nanoparticles that contain polymeric {\textquoteleft}gates{\textquoteright} to enable external control (via temperature changes) of glycan surface expression, as an alternative to enzymatic control in nature. This approach offers a new dynamic multivalent scaffold for glycan recognition.",

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AB - Nature dynamically controls carbohydrate expression on cells rather than static presentation. Here we report synthetic glycosylated nanoparticles that contain polymeric ‘gates’ to enable external control (via temperature changes) of glycan surface expression, as an alternative to enzymatic control in nature. This approach offers a new dynamic multivalent scaffold for glycan recognition.

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JO - Nanoscale Horizons

JF - Nanoscale Horizons

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Externally controllable glycan presentation on nanoparticle surfaces to modulate lectin recognition

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