Extracellular Matrix Molecule-Based Capture of Mesenchymal Stromal Cells Under Flow

Teresa Massam-Wu; Stuart A Cain; Catherine Kielty

doi:10.1007/978-1-4939-7553-2_16

Extracellular Matrix Molecule-Based Capture of Mesenchymal Stromal Cells Under Flow

Teresa Massam-Wu, Stuart A Cain, Catherine Kielty

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

We present a method to capture mesenchymal stromal cells (MSCs) by adhesion to extracellular matrix (ECM) molecules under flow conditions. The technique simulates a physiological system and exploits the natural biological interactions of cells, through integrin receptors, with their ECM. The system offers an insight into how MSCs could be targeted/localized to the site of interest (graft) following intravenous injection.

Original language	English
Title of host publication	The Surfaceome
Publisher	Humana Press, Inc
Pages	249-260
Number of pages	12
Volume	1722
ISBN (Electronic)	978-1-4939-7553-2
ISBN (Print)	978-1-4939-7551-8
DOIs	https://doi.org/10.1007/978-1-4939-7553-2_16
Publication status	Published - 2018

Publication series

Name	Methods in molecular biology (Clifton, N.J.)
Publisher	Humana Press, Inc.
ISSN (Print)	1064-3745

Keywords

Journal Article

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10.1007/978-1-4939-7553-2_16

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abstract = "We present a method to capture mesenchymal stromal cells (MSCs) by adhesion to extracellular matrix (ECM) molecules under flow conditions. The technique simulates a physiological system and exploits the natural biological interactions of cells, through integrin receptors, with their ECM. The system offers an insight into how MSCs could be targeted/localized to the site of interest (graft) following intravenous injection.",

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AU - Cain, Stuart A

AU - Kielty, Catherine

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N2 - We present a method to capture mesenchymal stromal cells (MSCs) by adhesion to extracellular matrix (ECM) molecules under flow conditions. The technique simulates a physiological system and exploits the natural biological interactions of cells, through integrin receptors, with their ECM. The system offers an insight into how MSCs could be targeted/localized to the site of interest (graft) following intravenous injection.

AB - We present a method to capture mesenchymal stromal cells (MSCs) by adhesion to extracellular matrix (ECM) molecules under flow conditions. The technique simulates a physiological system and exploits the natural biological interactions of cells, through integrin receptors, with their ECM. The system offers an insight into how MSCs could be targeted/localized to the site of interest (graft) following intravenous injection.

KW - Journal Article

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DO - 10.1007/978-1-4939-7553-2_16

M3 - Chapter

C2 - 29264810

SN - 978-1-4939-7551-8

VL - 1722

T3 - Methods in molecular biology (Clifton, N.J.)

SP - 249

EP - 260

BT - The Surfaceome

PB - Humana Press, Inc

ER -

Extracellular Matrix Molecule-Based Capture of Mesenchymal Stromal Cells Under Flow

Abstract

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