Facial appearance reflects human familial longevity and cardiovascular disease risk in healthy individuals

David A. Gunn; Anton J M De Craen; Joanne L. Dick; Cyrena C. Tomlin; Diana Van Heemst; Sharon D. Catt; Tamara Griffiths; Stephanie Ogden; Andrea B. Maier; Peter G. Murray; Christopher E M Griffiths; P. Eline Slagboom; Rudi G J Westendorp; Stephen Kritchevsky

doi:10.1093/gerona/gls154

Facial appearance reflects human familial longevity and cardiovascular disease risk in healthy individuals

David A. Gunn, Anton J M De Craen, Joanne L. Dick, Cyrena C. Tomlin, Diana Van Heemst, Sharon D. Catt, Tamara Griffiths, Stephanie Ogden, Andrea B. Maier, Peter G. Murray, Christopher E M Griffiths, P. Eline Slagboom, Rudi G J Westendorp, Stephen Kritchevsky

Research output: Contribution to journal › Article › peer-review

Abstract

Background.As facial appearance can be readily quantified and skin tissue easily accessed, they could be valuable tools for determining how biological mechanisms influence tissue degeneration with age and, consequently, human health and lifespan. It is unknown, however, whether appearance reflects disease risk or lifespan independently of factors already known to associate with both health and appearance.Methods.In a cross-sectional study, we compared the amount of skin wrinkling on a sun-protected site (upper inner arm) and the facial appearance of 261 offspring (mean age 63.2 y) of nonagenarian siblings with 253 age-matched controls (mean age 62.7 y), all with no reported disease history. We next examined whether any appearance features that significantly associated with familial longevity also associated with the Framingham cardiovascular disease (CVD) risk score. All analyses were adjusted for chronological age, smoking, photodamage, and body mass index.Results.Female and male offspring had reduced upper inner arm skin wrinkling (p =. 03 and p

Original language	English
Pages (from-to)	145-152
Number of pages	7
Journal	Journals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume	68
Issue number	2
DOIs	https://doi.org/10.1093/gerona/gls154
Publication status	Published - Feb 2013

Keywords

Aging
Cardiovascular disease
Longevity
Perceived age
Skin

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/gerona/gls154

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Gunn, D. A., De Craen, A. J. M., Dick, J. L., Tomlin, C. C., Van Heemst, D., Catt, S. D., Griffiths, T., Ogden, S., Maier, A. B., Murray, P. G., Griffiths, C. E. M., Slagboom, P. E., Westendorp, R. G. J., & Kritchevsky, S. (2013). Facial appearance reflects human familial longevity and cardiovascular disease risk in healthy individuals. Journals of Gerontology - Series A Biological Sciences and Medical Sciences, 68(2), 145-152. https://doi.org/10.1093/gerona/gls154

@article{76ac21d192bf449ab63e7aaea73530db,

title = "Facial appearance reflects human familial longevity and cardiovascular disease risk in healthy individuals",

abstract = "Background.As facial appearance can be readily quantified and skin tissue easily accessed, they could be valuable tools for determining how biological mechanisms influence tissue degeneration with age and, consequently, human health and lifespan. It is unknown, however, whether appearance reflects disease risk or lifespan independently of factors already known to associate with both health and appearance.Methods.In a cross-sectional study, we compared the amount of skin wrinkling on a sun-protected site (upper inner arm) and the facial appearance of 261 offspring (mean age 63.2 y) of nonagenarian siblings with 253 age-matched controls (mean age 62.7 y), all with no reported disease history. We next examined whether any appearance features that significantly associated with familial longevity also associated with the Framingham cardiovascular disease (CVD) risk score. All analyses were adjusted for chronological age, smoking, photodamage, and body mass index.Results.Female and male offspring had reduced upper inner arm skin wrinkling (p =. 03 and p",

keywords = "Aging, Cardiovascular disease, Longevity, Perceived age, Skin",

author = "Gunn, {David A.} and {De Craen}, {Anton J M} and Dick, {Joanne L.} and Tomlin, {Cyrena C.} and {Van Heemst}, Diana and Catt, {Sharon D.} and Tamara Griffiths and Stephanie Ogden and Maier, {Andrea B.} and Murray, {Peter G.} and Griffiths, {Christopher E M} and Slagboom, {P. Eline} and Westendorp, {Rudi G J} and Stephen Kritchevsky",

year = "2013",

month = feb,

doi = "10.1093/gerona/gls154",

language = "English",

volume = "68",

pages = "145--152",

journal = "Journals of Gerontology - Series A Biological Sciences and Medical Sciences",

issn = "1079-5006",

publisher = "Oxford University Press",

number = "2",

}

Gunn, DA, De Craen, AJM, Dick, JL, Tomlin, CC, Van Heemst, D, Catt, SD, Griffiths, T, Ogden, S, Maier, AB, Murray, PG, Griffiths, CEM, Slagboom, PE, Westendorp, RGJ & Kritchevsky, S 2013, 'Facial appearance reflects human familial longevity and cardiovascular disease risk in healthy individuals', Journals of Gerontology - Series A Biological Sciences and Medical Sciences, vol. 68, no. 2, pp. 145-152. https://doi.org/10.1093/gerona/gls154

TY - JOUR

T1 - Facial appearance reflects human familial longevity and cardiovascular disease risk in healthy individuals

AU - Gunn, David A.

AU - De Craen, Anton J M

AU - Dick, Joanne L.

AU - Tomlin, Cyrena C.

AU - Van Heemst, Diana

AU - Catt, Sharon D.

AU - Griffiths, Tamara

AU - Ogden, Stephanie

AU - Maier, Andrea B.

AU - Murray, Peter G.

AU - Griffiths, Christopher E M

AU - Slagboom, P. Eline

AU - Westendorp, Rudi G J

AU - Kritchevsky, Stephen

PY - 2013/2

Y1 - 2013/2

N2 - Background.As facial appearance can be readily quantified and skin tissue easily accessed, they could be valuable tools for determining how biological mechanisms influence tissue degeneration with age and, consequently, human health and lifespan. It is unknown, however, whether appearance reflects disease risk or lifespan independently of factors already known to associate with both health and appearance.Methods.In a cross-sectional study, we compared the amount of skin wrinkling on a sun-protected site (upper inner arm) and the facial appearance of 261 offspring (mean age 63.2 y) of nonagenarian siblings with 253 age-matched controls (mean age 62.7 y), all with no reported disease history. We next examined whether any appearance features that significantly associated with familial longevity also associated with the Framingham cardiovascular disease (CVD) risk score. All analyses were adjusted for chronological age, smoking, photodamage, and body mass index.Results.Female and male offspring had reduced upper inner arm skin wrinkling (p =. 03 and p

AB - Background.As facial appearance can be readily quantified and skin tissue easily accessed, they could be valuable tools for determining how biological mechanisms influence tissue degeneration with age and, consequently, human health and lifespan. It is unknown, however, whether appearance reflects disease risk or lifespan independently of factors already known to associate with both health and appearance.Methods.In a cross-sectional study, we compared the amount of skin wrinkling on a sun-protected site (upper inner arm) and the facial appearance of 261 offspring (mean age 63.2 y) of nonagenarian siblings with 253 age-matched controls (mean age 62.7 y), all with no reported disease history. We next examined whether any appearance features that significantly associated with familial longevity also associated with the Framingham cardiovascular disease (CVD) risk score. All analyses were adjusted for chronological age, smoking, photodamage, and body mass index.Results.Female and male offspring had reduced upper inner arm skin wrinkling (p =. 03 and p

KW - Aging

KW - Cardiovascular disease

KW - Longevity

KW - Perceived age

KW - Skin

U2 - 10.1093/gerona/gls154

DO - 10.1093/gerona/gls154

M3 - Article

C2 - 22879455

SN - 1079-5006

VL - 68

SP - 145

EP - 152

JO - Journals of Gerontology - Series A Biological Sciences and Medical Sciences

JF - Journals of Gerontology - Series A Biological Sciences and Medical Sciences

IS - 2

ER -

Facial appearance reflects human familial longevity and cardiovascular disease risk in healthy individuals

Abstract

Keywords

UN SDGs

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