TY - JOUR
T1 - Facilitation of displacements at the 6-position of purines by the use of 1,4-diazabicyclo[2.2.2]octane as leaving group. [Erratum to document cited in CA126:251122]
AU - Lembicz, Nicola K
AU - Grant, Sharon
AU - Clegg, William
AU - Griffin, Roger J
AU - Heath, Sarah L
AU - Golding, Bernard T
N1 - CAPLUS AN 1997:807301(Journal)
PY - 1997
Y1 - 1997
N2 - The ability of 1,4-diazabicyclo[2.2.2]octane (DABCO) to catalyze reactions of 2-amino-9-benzyl-6-chloro-9H-purine with alkoxides has been demonstrated (J. A. Linn, E. W. McLean and J. L. Kelley, J. Chem. Soc., Chem. Commun., 1994, 913). These authors also characterized 1-1-(2-amino-9-benzyl-9H-purin-6-yl)-4-aza-1-azoniabicyclo[2.2.2]octane chloride from reaction of DABCO with 2-amino-9-benzyl-6-chloro-9H-purine in DMF. DABCO has been shown to catalyze reactions or 6-chloropurines with cyanide (M. Hocek and A. Holy, Collect. Czech. Chem. Commun., 1995, 60, 1386). [on SciFinder(R)]
AB - The ability of 1,4-diazabicyclo[2.2.2]octane (DABCO) to catalyze reactions of 2-amino-9-benzyl-6-chloro-9H-purine with alkoxides has been demonstrated (J. A. Linn, E. W. McLean and J. L. Kelley, J. Chem. Soc., Chem. Commun., 1994, 913). These authors also characterized 1-1-(2-amino-9-benzyl-9H-purin-6-yl)-4-aza-1-azoniabicyclo[2.2.2]octane chloride from reaction of DABCO with 2-amino-9-benzyl-6-chloro-9H-purine in DMF. DABCO has been shown to catalyze reactions or 6-chloropurines with cyanide (M. Hocek and A. Holy, Collect. Czech. Chem. Commun., 1995, 60, 1386). [on SciFinder(R)]
KW - erratum purine diazabicyclooctane prepn substitution
KW - purine diazabicyclooctane prepn substitution erratum
KW - alkoxypurine prepn erratum
M3 - Article
JO - J. Chem. Soc., Perkin Trans. 1
JF - J. Chem. Soc., Perkin Trans. 1
IS - 23
ER -