Facilitation of displacements at the 6-position of purines by the use of 1,4-diazabicyclo[2.2.2]octane as leaving group

Nicola K Lembicz; Sharon Grant; William Clegg; Roger J Griffin; Sarah L Heath; Bernard T Golding

Facilitation of displacements at the 6-position of purines by the use of 1,4-diazabicyclo[2.2.2]octane as leaving group

Nicola K Lembicz, Sharon Grant, William Clegg, Roger J Griffin, Sarah L Heath, Bernard T Golding

Research output: Contribution to journal › Article › peer-review

Abstract

Reactions of 6-chloropurines with 1,4-diazabicyclo[2.2.2]octane (DABCO) give the corresponding 'DABCO-purines' I (X = NH2, H, Cl, Y = H; X = NH2, Y = β-D-ribofuranosyl), which undergo facile displacement reactions with alkoxides in DMSO to afford 6-oxy-substituted purines II (R = Me, allyl, CH2Ph, cyclohexylmethyl, 2-thienylmethyl, etc.). [on SciFinder(R)]

Original language	English
Pages (from-to)	185-186
Number of pages	2
Journal	J. Chem. Soc., Perkin Trans. 1
Issue number	3
Publication status	Published - 1997

Keywords

purine diazabicyclooctane prepn substitution
alkoxypurine prepn

Cite this

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title = "Facilitation of displacements at the 6-position of purines by the use of 1,4-diazabicyclo[2.2.2]octane as leaving group",

abstract = "Reactions of 6-chloropurines with 1,4-diazabicyclo[2.2.2]octane (DABCO) give the corresponding 'DABCO-purines' I (X = NH2, H, Cl, Y = H; X = NH2, Y = β-D-ribofuranosyl), which undergo facile displacement reactions with alkoxides in DMSO to afford 6-oxy-substituted purines II (R = Me, allyl, CH2Ph, cyclohexylmethyl, 2-thienylmethyl, etc.). [on SciFinder(R)]",

keywords = "purine diazabicyclooctane prepn substitution, alkoxypurine prepn",

author = "Lembicz, {Nicola K} and Sharon Grant and William Clegg and Griffin, {Roger J} and Heath, {Sarah L} and Golding, {Bernard T}",

note = "CAPLUS AN 1997:136347(Journal)",

year = "1997",

language = "English",

pages = "185--186",

journal = "J. Chem. Soc., Perkin Trans. 1",

publisher = "Chemical Society",

number = "3",

}

TY - JOUR

T1 - Facilitation of displacements at the 6-position of purines by the use of 1,4-diazabicyclo[2.2.2]octane as leaving group

AU - Lembicz, Nicola K

AU - Grant, Sharon

AU - Clegg, William

AU - Griffin, Roger J

AU - Heath, Sarah L

AU - Golding, Bernard T

N1 - CAPLUS AN 1997:136347(Journal)

PY - 1997

Y1 - 1997

N2 - Reactions of 6-chloropurines with 1,4-diazabicyclo[2.2.2]octane (DABCO) give the corresponding 'DABCO-purines' I (X = NH2, H, Cl, Y = H; X = NH2, Y = β-D-ribofuranosyl), which undergo facile displacement reactions with alkoxides in DMSO to afford 6-oxy-substituted purines II (R = Me, allyl, CH2Ph, cyclohexylmethyl, 2-thienylmethyl, etc.). [on SciFinder(R)]

AB - Reactions of 6-chloropurines with 1,4-diazabicyclo[2.2.2]octane (DABCO) give the corresponding 'DABCO-purines' I (X = NH2, H, Cl, Y = H; X = NH2, Y = β-D-ribofuranosyl), which undergo facile displacement reactions with alkoxides in DMSO to afford 6-oxy-substituted purines II (R = Me, allyl, CH2Ph, cyclohexylmethyl, 2-thienylmethyl, etc.). [on SciFinder(R)]

KW - purine diazabicyclooctane prepn substitution

KW - alkoxypurine prepn

M3 - Article

SP - 185

EP - 186

JO - J. Chem. Soc., Perkin Trans. 1

JF - J. Chem. Soc., Perkin Trans. 1

IS - 3

ER -

Facilitation of displacements at the 6-position of purines by the use of 1,4-diazabicyclo[2.2.2]octane as leaving group

Abstract

Keywords

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