Factor V Leiden homozygosity, dyspnea, and reduced pulmonary function

Klaus Juul, Anne Tybjærg-Hansen, Jann Mortensen, Peter Lange, Jørgen Vestbo, Børge G. Nordestgaard

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Background: Factor V Leiden homozygosity predisposes patients to deep venous thrombosis and major pulmonary thromboembolism. Consequently, factor V Leiden homozygosity could, via unrecognized repeated minor pulmonary thromboemboli, cause chronic pulmonary disease. Wetested the hypothesis that factor V Leiden homozygosity is associated with pulmonary symptoms and signs. Methods: We studied a general population sample of 9253 individuals from the Copenhagen City Heart Study who were examined in 1991-1994. Of these, 6475 participants were also examined in 1976-1978 and/or 1981-1983. End points were dyspnea and lung function. Results: Among 20 factor V Leiden homozygotes, a mean±SD of 32%±11% had severe dyspnea compared with 6%±0.3% of 8534 noncarriers (χ2 test; P
    Original languageEnglish
    Pages (from-to)2032-2036
    Number of pages4
    JournalArchives of internal medicine
    Volume165
    Issue number17
    DOIs
    Publication statusPublished - 26 Sept 2005

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