TY - JOUR
T1 - Factor V Leiden homozygosity, dyspnea, and reduced pulmonary function
AU - Juul, Klaus
AU - Tybjærg-Hansen, Anne
AU - Mortensen, Jann
AU - Lange, Peter
AU - Vestbo, Jørgen
AU - Nordestgaard, Børge G.
PY - 2005/9/26
Y1 - 2005/9/26
N2 - Background: Factor V Leiden homozygosity predisposes patients to deep venous thrombosis and major pulmonary thromboembolism. Consequently, factor V Leiden homozygosity could, via unrecognized repeated minor pulmonary thromboemboli, cause chronic pulmonary disease. Wetested the hypothesis that factor V Leiden homozygosity is associated with pulmonary symptoms and signs. Methods: We studied a general population sample of 9253 individuals from the Copenhagen City Heart Study who were examined in 1991-1994. Of these, 6475 participants were also examined in 1976-1978 and/or 1981-1983. End points were dyspnea and lung function. Results: Among 20 factor V Leiden homozygotes, a mean±SD of 32%±11% had severe dyspnea compared with 6%±0.3% of 8534 noncarriers (χ2 test; P
AB - Background: Factor V Leiden homozygosity predisposes patients to deep venous thrombosis and major pulmonary thromboembolism. Consequently, factor V Leiden homozygosity could, via unrecognized repeated minor pulmonary thromboemboli, cause chronic pulmonary disease. Wetested the hypothesis that factor V Leiden homozygosity is associated with pulmonary symptoms and signs. Methods: We studied a general population sample of 9253 individuals from the Copenhagen City Heart Study who were examined in 1991-1994. Of these, 6475 participants were also examined in 1976-1978 and/or 1981-1983. End points were dyspnea and lung function. Results: Among 20 factor V Leiden homozygotes, a mean±SD of 32%±11% had severe dyspnea compared with 6%±0.3% of 8534 noncarriers (χ2 test; P
U2 - 10.1001/archinte.165.17.2032
DO - 10.1001/archinte.165.17.2032
M3 - Article
SN - 0003-9926
VL - 165
SP - 2032
EP - 2036
JO - Archives of internal medicine
JF - Archives of internal medicine
IS - 17
ER -