Factors associated with damage accrual in patients with systemic lupus erythematosus: Results from the Systemic Lupus International Collaborating Clinics (SLICC) Inception Cohort

Ian N. Bruce, Aidan G. O'Keeffe, Vern Farewell, John G. Hanly, Susan Manzi, Li Su, Dafna D. Gladman, Sang Cheol Bae, Jorge Sanchez-Guerrero, Juanita Romero-Diaz, Caroline Gordon, Daniel J. Wallace, Ann E. Clarke, Sasha Bernatsky, Ellen M. Ginzler, David A. Isenberg, Anisur Rahman, Joan T. Merrill, Graciela S. Alarcón, Barri J. FesslerPaul R. Fortin, Michelle Petri, Kristjan Steinsson, Mary Anne Dooley, Munther A. Khamashta, Rosalind Ramsey-Goldman, Asad A. Zoma, Gunnar K. Sturfelt, Ola Nived, [Unknown] Cynthia Aranow, Meggan Mackay, Manuel Ramos-Casals, Ronald F. van Vollenhoven, Kenneth C. Kalunian, Guillermo Ruiz-Irastorza, Sam Lim, Diane L. Kamen, Christine A. Peschken, Murat Inanc, Murray B. Urowitz

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Background and aims We studied damage accrual and factors determining development and progression of damage in an international cohort of systemic lupus erythematosus (SLE) patients. Methods The Systemic Lupus International Collaborating Clinics (SLICC) Inception Cohort recruited patients within 15 months of developing four or more 1997 American College of Rheumatology (ACR) criteria for SLE; the SLICC/ACR damage index (SDI) was measured annually. We assessed relative rates of transition using maximum likelihood estimation in a multistate model. The Kaplan-Meier method estimated the probabilities for time to first increase in SDI score and Cox regression analysis was used to assess mortality. Results We recruited 1722 patients; mean (SD) age 35.0 (13.4) years at cohort entry. Patients with damage at enrolment were more likely to have further worsening of SDI (SDI 0 vs ≥1; p
    Original languageEnglish
    Pages (from-to)1706-1713
    JournalAnnals of the rheumatic diseases
    Volume74
    Issue number9
    DOIs
    Publication statusPublished - 16 May 2014

    Keywords

    • Corticosteroids
    • Inflammation
    • Outcomes research
    • Systemic Lupus Erythematosus

    Fingerprint

    Dive into the research topics of 'Factors associated with damage accrual in patients with systemic lupus erythematosus: Results from the Systemic Lupus International Collaborating Clinics (SLICC) Inception Cohort'. Together they form a unique fingerprint.

    Cite this