Factors associated with damage accrual in patients with systemic lupus erythematosus: Results from the Systemic Lupus International Collaborating Clinics (SLICC) Inception Cohort

Ian N. Bruce; Aidan G. O'Keeffe; Vern Farewell; John G. Hanly; Susan Manzi; Li Su; Dafna D. Gladman; Sang Cheol Bae; Jorge Sanchez-Guerrero; Juanita Romero-Diaz; Caroline Gordon; Daniel J. Wallace; Ann E. Clarke; Sasha Bernatsky; Ellen M. Ginzler; David A. Isenberg; Anisur Rahman; Joan T. Merrill; Graciela S. Alarcón; Barri J. Fessler; Paul R. Fortin; Michelle Petri; Kristjan Steinsson; Mary Anne Dooley; Munther A. Khamashta; Rosalind Ramsey-Goldman; Asad A. Zoma; Gunnar K. Sturfelt; Ola Nived; [Unknown] Cynthia Aranow; Meggan Mackay; Manuel Ramos-Casals; Ronald F. van Vollenhoven; Kenneth C. Kalunian; Guillermo Ruiz-Irastorza; Sam Lim; Diane L. Kamen; Christine A. Peschken; Murat Inanc; Murray B. Urowitz

doi:10.1136/annrheumdis-2013-205171

Factors associated with damage accrual in patients with systemic lupus erythematosus: Results from the Systemic Lupus International Collaborating Clinics (SLICC) Inception Cohort

Ian N. Bruce, Aidan G. O'Keeffe, Vern Farewell, John G. Hanly, Susan Manzi, Li Su, Dafna D. Gladman, Sang Cheol Bae, Jorge Sanchez-Guerrero, Juanita Romero-Diaz, Caroline Gordon, Daniel J. Wallace, Ann E. Clarke, Sasha Bernatsky, Ellen M. Ginzler, David A. Isenberg, Anisur Rahman, Joan T. Merrill, Graciela S. Alarcón, Barri J. FesslerPaul R. Fortin, Michelle Petri, Kristjan Steinsson, Mary Anne Dooley, Munther A. Khamashta, Rosalind Ramsey-Goldman, Asad A. Zoma, Gunnar K. Sturfelt, Ola Nived, [Unknown] Cynthia Aranow, Meggan Mackay, Manuel Ramos-Casals, Ronald F. van Vollenhoven, Kenneth C. Kalunian, Guillermo Ruiz-Irastorza, Sam Lim, Diane L. Kamen, Christine A. Peschken, Murat Inanc, Murray B. Urowitz

Research output: Contribution to journal › Article › peer-review

Abstract

Background and aims We studied damage accrual and factors determining development and progression of damage in an international cohort of systemic lupus erythematosus (SLE) patients. Methods The Systemic Lupus International Collaborating Clinics (SLICC) Inception Cohort recruited patients within 15 months of developing four or more 1997 American College of Rheumatology (ACR) criteria for SLE; the SLICC/ACR damage index (SDI) was measured annually. We assessed relative rates of transition using maximum likelihood estimation in a multistate model. The Kaplan-Meier method estimated the probabilities for time to first increase in SDI score and Cox regression analysis was used to assess mortality. Results We recruited 1722 patients; mean (SD) age 35.0 (13.4) years at cohort entry. Patients with damage at enrolment were more likely to have further worsening of SDI (SDI 0 vs ≥1; p

Original language	English
Pages (from-to)	1706-1713
Journal	Annals of the rheumatic diseases
Volume	74
Issue number	9
DOIs	https://doi.org/10.1136/annrheumdis-2013-205171
Publication status	Published - 16 May 2014

Keywords

Corticosteroids
Inflammation
Outcomes research
Systemic Lupus Erythematosus

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1136/annrheumdis-2013-205171Licence: CC BY-NC

Arthritis Research UK Centre of Excellence in Epidemiology.
Symmons, D. (PI), Bruce, I. (CoI), Dixon, W. (CoI), Felson, D. (CoI), Hyrich, K. (CoI), Lunt, M. (CoI), Mcbeth, J. (CoI), O'Neill, T. (CoI) & Verstappen, S. (CoI)
1/08/13 → 31/07/18
Project: Research

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Bruce, I. N., O'Keeffe, A. G., Farewell, V., Hanly, J. G., Manzi, S., Su, L., Gladman, D. D., Bae, S. C., Sanchez-Guerrero, J., Romero-Diaz, J., Gordon, C., Wallace, D. J., Clarke, A. E., Bernatsky, S., Ginzler, E. M., Isenberg, D. A., Rahman, A., Merrill, J. T., Alarcón, G. S., ... Urowitz, M. B. (2014). Factors associated with damage accrual in patients with systemic lupus erythematosus: Results from the Systemic Lupus International Collaborating Clinics (SLICC) Inception Cohort. Annals of the rheumatic diseases, 74(9), 1706-1713. https://doi.org/10.1136/annrheumdis-2013-205171

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title = "Factors associated with damage accrual in patients with systemic lupus erythematosus: Results from the Systemic Lupus International Collaborating Clinics (SLICC) Inception Cohort",

abstract = "Background and aims We studied damage accrual and factors determining development and progression of damage in an international cohort of systemic lupus erythematosus (SLE) patients. Methods The Systemic Lupus International Collaborating Clinics (SLICC) Inception Cohort recruited patients within 15 months of developing four or more 1997 American College of Rheumatology (ACR) criteria for SLE; the SLICC/ACR damage index (SDI) was measured annually. We assessed relative rates of transition using maximum likelihood estimation in a multistate model. The Kaplan-Meier method estimated the probabilities for time to first increase in SDI score and Cox regression analysis was used to assess mortality. Results We recruited 1722 patients; mean (SD) age 35.0 (13.4) years at cohort entry. Patients with damage at enrolment were more likely to have further worsening of SDI (SDI 0 vs ≥1; p",

keywords = "Corticosteroids, Inflammation, Outcomes research, Systemic Lupus Erythematosus",

author = "Bruce, {Ian N.} and O'Keeffe, {Aidan G.} and Vern Farewell and Hanly, {John G.} and Susan Manzi and Li Su and Gladman, {Dafna D.} and Bae, {Sang Cheol} and Jorge Sanchez-Guerrero and Juanita Romero-Diaz and Caroline Gordon and Wallace, {Daniel J.} and Clarke, {Ann E.} and Sasha Bernatsky and Ginzler, {Ellen M.} and Isenberg, {David A.} and Anisur Rahman and Merrill, {Joan T.} and Alarc{\'o}n, {Graciela S.} and Fessler, {Barri J.} and Fortin, {Paul R.} and Michelle Petri and Kristjan Steinsson and Dooley, {Mary Anne} and Khamashta, {Munther A.} and Rosalind Ramsey-Goldman and Zoma, {Asad A.} and Sturfelt, {Gunnar K.} and Ola Nived and {Cynthia Aranow}, [Unknown] and Meggan Mackay and Manuel Ramos-Casals and {van Vollenhoven}, {Ronald F.} and Kalunian, {Kenneth C.} and Guillermo Ruiz-Irastorza and Sam Lim and Kamen, {Diane L.} and Peschken, {Christine A.} and Murat Inanc and Urowitz, {Murray B.}",

year = "2014",

month = may,

day = "16",

doi = "10.1136/annrheumdis-2013-205171",

language = "English",

volume = "74",

pages = "1706--1713",

journal = "Annals of the rheumatic diseases",

issn = "0003-4967",

publisher = "Elsevier BV",

number = "9",

}

Bruce, IN, O'Keeffe, AG, Farewell, V, Hanly, JG, Manzi, S, Su, L, Gladman, DD, Bae, SC, Sanchez-Guerrero, J, Romero-Diaz, J, Gordon, C, Wallace, DJ, Clarke, AE, Bernatsky, S, Ginzler, EM, Isenberg, DA, Rahman, A, Merrill, JT, Alarcón, GS, Fessler, BJ, Fortin, PR, Petri, M, Steinsson, K, Dooley, MA, Khamashta, MA, Ramsey-Goldman, R, Zoma, AA, Sturfelt, GK, Nived, O, Cynthia Aranow, U, Mackay, M, Ramos-Casals, M, van Vollenhoven, RF, Kalunian, KC, Ruiz-Irastorza, G, Lim, S, Kamen, DL, Peschken, CA, Inanc, M & Urowitz, MB 2014, 'Factors associated with damage accrual in patients with systemic lupus erythematosus: Results from the Systemic Lupus International Collaborating Clinics (SLICC) Inception Cohort', Annals of the rheumatic diseases, vol. 74, no. 9, pp. 1706-1713. https://doi.org/10.1136/annrheumdis-2013-205171

Factors associated with damage accrual in patients with systemic lupus erythematosus: Results from the Systemic Lupus International Collaborating Clinics (SLICC) Inception Cohort. / Bruce, Ian N.; O'Keeffe, Aidan G.; Farewell, Vern et al.
In: Annals of the rheumatic diseases, Vol. 74, No. 9, 16.05.2014, p. 1706-1713.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Factors associated with damage accrual in patients with systemic lupus erythematosus: Results from the Systemic Lupus International Collaborating Clinics (SLICC) Inception Cohort

AU - Bruce, Ian N.

AU - O'Keeffe, Aidan G.

AU - Farewell, Vern

AU - Hanly, John G.

AU - Manzi, Susan

AU - Su, Li

AU - Gladman, Dafna D.

AU - Bae, Sang Cheol

AU - Sanchez-Guerrero, Jorge

AU - Romero-Diaz, Juanita

AU - Gordon, Caroline

AU - Wallace, Daniel J.

AU - Clarke, Ann E.

AU - Bernatsky, Sasha

AU - Ginzler, Ellen M.

AU - Isenberg, David A.

AU - Rahman, Anisur

AU - Merrill, Joan T.

AU - Alarcón, Graciela S.

AU - Fessler, Barri J.

AU - Fortin, Paul R.

AU - Petri, Michelle

AU - Steinsson, Kristjan

AU - Dooley, Mary Anne

AU - Khamashta, Munther A.

AU - Ramsey-Goldman, Rosalind

AU - Zoma, Asad A.

AU - Sturfelt, Gunnar K.

AU - Nived, Ola

AU - Cynthia Aranow, [Unknown]

AU - Mackay, Meggan

AU - Ramos-Casals, Manuel

AU - van Vollenhoven, Ronald F.

AU - Kalunian, Kenneth C.

AU - Ruiz-Irastorza, Guillermo

AU - Lim, Sam

AU - Kamen, Diane L.

AU - Peschken, Christine A.

AU - Inanc, Murat

AU - Urowitz, Murray B.

PY - 2014/5/16

Y1 - 2014/5/16

N2 - Background and aims We studied damage accrual and factors determining development and progression of damage in an international cohort of systemic lupus erythematosus (SLE) patients. Methods The Systemic Lupus International Collaborating Clinics (SLICC) Inception Cohort recruited patients within 15 months of developing four or more 1997 American College of Rheumatology (ACR) criteria for SLE; the SLICC/ACR damage index (SDI) was measured annually. We assessed relative rates of transition using maximum likelihood estimation in a multistate model. The Kaplan-Meier method estimated the probabilities for time to first increase in SDI score and Cox regression analysis was used to assess mortality. Results We recruited 1722 patients; mean (SD) age 35.0 (13.4) years at cohort entry. Patients with damage at enrolment were more likely to have further worsening of SDI (SDI 0 vs ≥1; p

AB - Background and aims We studied damage accrual and factors determining development and progression of damage in an international cohort of systemic lupus erythematosus (SLE) patients. Methods The Systemic Lupus International Collaborating Clinics (SLICC) Inception Cohort recruited patients within 15 months of developing four or more 1997 American College of Rheumatology (ACR) criteria for SLE; the SLICC/ACR damage index (SDI) was measured annually. We assessed relative rates of transition using maximum likelihood estimation in a multistate model. The Kaplan-Meier method estimated the probabilities for time to first increase in SDI score and Cox regression analysis was used to assess mortality. Results We recruited 1722 patients; mean (SD) age 35.0 (13.4) years at cohort entry. Patients with damage at enrolment were more likely to have further worsening of SDI (SDI 0 vs ≥1; p

KW - Corticosteroids

KW - Inflammation

KW - Outcomes research

KW - Systemic Lupus Erythematosus

U2 - 10.1136/annrheumdis-2013-205171

DO - 10.1136/annrheumdis-2013-205171

M3 - Article

C2 - 24834926

SN - 0003-4967

VL - 74

SP - 1706

EP - 1713

JO - Annals of the rheumatic diseases

JF - Annals of the rheumatic diseases

IS - 9

ER -

Factors associated with damage accrual in patients with systemic lupus erythematosus: Results from the Systemic Lupus International Collaborating Clinics (SLICC) Inception Cohort

Abstract

Keywords

UN SDGs

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Projects

Arthritis Research UK Centre of Excellence in Epidemiology.

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