Familial chronic lymphocytic leukaemia: A survey and review of published studies

Martin Yuille; E. Matutes; A. Marossy; B. Hilditch; D. Catovsky; R. S. Houlston

doi:10.1046/j.1365-2141.2000.02111.x

Familial chronic lymphocytic leukaemia: A survey and review of published studies

Martin Yuille, E. Matutes, A. Marossy, B. Hilditch, D. Catovsky, R. S. Houlston

Research output: Contribution to journal › Article › peer-review

Abstract

B-cell chronic lymphocytic leukaemia (CLL) is the most common form of leukaemia. To gain insight into the role of inherited factors in the disease, we have conducted a survey of the family histories of 268 CLL patients and have reviewed published familial cases and epidemiological studies. The results of our survey and published studies strongly support the hypothesis that a subset of the disease can be ascribed to a genetic predisposition. The most likely genetic model for inherited predisposition appears to be dominantly acting genes with pleiotropic effects because in many families CLL appears to be associated with other lymphoproliferative disorders.

Original language	English
Pages (from-to)	794-799
Number of pages	5
Journal	British Journal of Haematology
Volume	109
Issue number	4
DOIs	https://doi.org/10.1046/j.1365-2141.2000.02111.x
Publication status	Published - 2000

Keywords

Familial chronic lymphocytic leukaemia

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1046/j.1365-2141.2000.02111.x

Cite this

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abstract = "B-cell chronic lymphocytic leukaemia (CLL) is the most common form of leukaemia. To gain insight into the role of inherited factors in the disease, we have conducted a survey of the family histories of 268 CLL patients and have reviewed published familial cases and epidemiological studies. The results of our survey and published studies strongly support the hypothesis that a subset of the disease can be ascribed to a genetic predisposition. The most likely genetic model for inherited predisposition appears to be dominantly acting genes with pleiotropic effects because in many families CLL appears to be associated with other lymphoproliferative disorders.",

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AU - Yuille, Martin

AU - Matutes, E.

AU - Marossy, A.

AU - Hilditch, B.

AU - Catovsky, D.

AU - Houlston, R. S.

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AB - B-cell chronic lymphocytic leukaemia (CLL) is the most common form of leukaemia. To gain insight into the role of inherited factors in the disease, we have conducted a survey of the family histories of 268 CLL patients and have reviewed published familial cases and epidemiological studies. The results of our survey and published studies strongly support the hypothesis that a subset of the disease can be ascribed to a genetic predisposition. The most likely genetic model for inherited predisposition appears to be dominantly acting genes with pleiotropic effects because in many families CLL appears to be associated with other lymphoproliferative disorders.

KW - Familial chronic lymphocytic leukaemia

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M3 - Article

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JO - British Journal of Haematology

JF - British Journal of Haematology

IS - 4

ER -

Familial chronic lymphocytic leukaemia: A survey and review of published studies

Abstract

Keywords

UN SDGs

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