Familial hypercholesterolaemia commonly presents with Achilles tenosynovitis

D. Beeharry; B. Coupe; E. W. Benbow; J. Morgan; S. Kwok; V. Charlton-Menys; M. France; P. N. Durrington

doi:10.1136/ard.2005.040766

Familial hypercholesterolaemia commonly presents with Achilles tenosynovitis

D. Beeharry, B. Coupe, E. W. Benbow, J. Morgan, S. Kwok, V. Charlton-Menys, M. France, P. N. Durrington

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Patients with heterozygous familial hypercholesterolaemia (HeFH) develop tendon xanthomata (TX), most commonly in their Achilles tendons. Even before tendons are chronically enlarged, tenosynovitis may occur and medical advice be sought. Untreated HeFH carries a high risk of premature coronary heart disease, which can be ameliorated by early diagnosis. Objective: To determine the prevalence of episodes of Achilles tendon pain in HeFH before its diagnosis. Methods: Patients with definite HeFH (Simon Broome criteria) attending a lipid clinic were identified. They completed a questionnaire asking about symptoms relating to their Achilles tendons. Unaffected spouses or cohabiting partners served as controls. Results: 133 patients (47% men) and 87 controls (51% men) participated. TX had been recognised by the referring physicians in 3 days, whereas only 6 (6.9% (1.6 to 12.2)) controls had done so (difference p

Original language	English
Pages (from-to)	312-315
Number of pages	3
Journal	Annals of the rheumatic diseases
Volume	65
Issue number	3
DOIs	https://doi.org/10.1136/ard.2005.040766
Publication status	Published - Mar 2006

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1136/ard.2005.040766

Cite this

@article{8c43500e91434b05b0fbdbcf6bacf9a9,

title = "Familial hypercholesterolaemia commonly presents with Achilles tenosynovitis",

abstract = "Background: Patients with heterozygous familial hypercholesterolaemia (HeFH) develop tendon xanthomata (TX), most commonly in their Achilles tendons. Even before tendons are chronically enlarged, tenosynovitis may occur and medical advice be sought. Untreated HeFH carries a high risk of premature coronary heart disease, which can be ameliorated by early diagnosis. Objective: To determine the prevalence of episodes of Achilles tendon pain in HeFH before its diagnosis. Methods: Patients with definite HeFH (Simon Broome criteria) attending a lipid clinic were identified. They completed a questionnaire asking about symptoms relating to their Achilles tendons. Unaffected spouses or cohabiting partners served as controls. Results: 133 patients (47% men) and 87 controls (51% men) participated. TX had been recognised by the referring physicians in 3 days, whereas only 6 (6.9% (1.6 to 12.2)) controls had done so (difference p",

author = "D. Beeharry and B. Coupe and Benbow, {E. W.} and J. Morgan and S. Kwok and V. Charlton-Menys and M. France and Durrington, {P. N.}",

year = "2006",

month = mar,

doi = "10.1136/ard.2005.040766",

language = "English",

volume = "65",

pages = "312--315",

journal = "Annals of the rheumatic diseases",

issn = "0003-4967",

publisher = "BMJ ",

number = "3",

}

TY - JOUR

T1 - Familial hypercholesterolaemia commonly presents with Achilles tenosynovitis

AU - Beeharry, D.

AU - Coupe, B.

AU - Benbow, E. W.

AU - Morgan, J.

AU - Kwok, S.

AU - Charlton-Menys, V.

AU - France, M.

AU - Durrington, P. N.

PY - 2006/3

Y1 - 2006/3

N2 - Background: Patients with heterozygous familial hypercholesterolaemia (HeFH) develop tendon xanthomata (TX), most commonly in their Achilles tendons. Even before tendons are chronically enlarged, tenosynovitis may occur and medical advice be sought. Untreated HeFH carries a high risk of premature coronary heart disease, which can be ameliorated by early diagnosis. Objective: To determine the prevalence of episodes of Achilles tendon pain in HeFH before its diagnosis. Methods: Patients with definite HeFH (Simon Broome criteria) attending a lipid clinic were identified. They completed a questionnaire asking about symptoms relating to their Achilles tendons. Unaffected spouses or cohabiting partners served as controls. Results: 133 patients (47% men) and 87 controls (51% men) participated. TX had been recognised by the referring physicians in 3 days, whereas only 6 (6.9% (1.6 to 12.2)) controls had done so (difference p

AB - Background: Patients with heterozygous familial hypercholesterolaemia (HeFH) develop tendon xanthomata (TX), most commonly in their Achilles tendons. Even before tendons are chronically enlarged, tenosynovitis may occur and medical advice be sought. Untreated HeFH carries a high risk of premature coronary heart disease, which can be ameliorated by early diagnosis. Objective: To determine the prevalence of episodes of Achilles tendon pain in HeFH before its diagnosis. Methods: Patients with definite HeFH (Simon Broome criteria) attending a lipid clinic were identified. They completed a questionnaire asking about symptoms relating to their Achilles tendons. Unaffected spouses or cohabiting partners served as controls. Results: 133 patients (47% men) and 87 controls (51% men) participated. TX had been recognised by the referring physicians in 3 days, whereas only 6 (6.9% (1.6 to 12.2)) controls had done so (difference p

U2 - 10.1136/ard.2005.040766

DO - 10.1136/ard.2005.040766

M3 - Article

SN - 0003-4967

VL - 65

SP - 312

EP - 315

JO - Annals of the rheumatic diseases

JF - Annals of the rheumatic diseases

IS - 3

ER -

Familial hypercholesterolaemia commonly presents with Achilles tenosynovitis

Abstract

UN SDGs

Access to Document

Fingerprint

Cite this