Familial pseudohyperkalaemia Chiswick: a novel congenital thermotropic variant of K and Na transport across the human re cell membrane

Anna Nicolaou, Philip G. Haines, CR Crawley, M. C. Chetty, Helen G. Jarvis, Suzanne E. Coles, J. Fisher, Gordon W. Stewart

    Research output: Contribution to journalArticle

    Abstract

    Two families with inherited abnormalities in Na
    and K transport across the red cell membrane are described.
    Both presented with `pseudohyperkalaemia' as a result of
    loss of K from the red cells on storage at room temperature.
    Routine haematology was essentially normal, except for
    macrocytosis in one family. Studies of the temperature
    dependence of the passive leak to K showed a novel shoulder
    pattern with a minimum at 258C, a maximum at 108C,
    followed by a further fall. As in other cases of red cell-based
    pseudohyperkalaemia, the abnormal temperature dependence
    of this `leak' flux could be held to account for the loss of K from
    the cells at room temperature. These cases represent a novel
    variant of the temperature dependence of the passive leak of K
    and Na across the red cell membrane, and can be classified
    as a mild, non-haemolytic form of the group known
    Original languageEnglish
    Pages (from-to)469-474
    JournalBritish Journal of Haematology
    Volume112
    Issue number2
    DOIs
    Publication statusPublished - Feb 2001

    Keywords

    • Pseudohyperkalaemia
    • Stomatocytosis
    • Temperature

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