Familial site-specific ovarian cancer is linked to BRCA1 on 17q12-21.

E Steichen-Gersdorf; H H Gallion; D Ford; C Girodet; D F Easton; R A DiCioccio; G Evans; M A Ponder; C Pye; S Mazoyer

Familial site-specific ovarian cancer is linked to BRCA1 on 17q12-21.

E Steichen-Gersdorf, H H Gallion, D Ford, C Girodet, D F Easton, R A DiCioccio, G Evans, M A Ponder, C Pye, S Mazoyer

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Abstract

In a study of nine families with "site-specific" ovarian cancer (criterion: three or more cases of epithelial ovarian cancer and no cases of breast cancer diagnosed at age <50 years) we have obtained evidence of linkage to the breast-ovarian cancer susceptibility gene, BRCA1 on 17q12-21. If the risk of cancer in these families is assumed to be restricted to the ovary, the best estimate of the proportion of families linked to BRCA1 is .78 (95% confidence interval .32-1.0). If predisposition to both breast and ovarian cancer is assumed, the proportion linked is 1.0 (95% confidence interval .46-1.0). The linkage of familial site-specific ovarian cancer to BRCA1 indicates the possibility of predictive testing in such families; however, this is only appropriate in families where the evidence for linkage to BRCA1 is conclusive.

Original language	English
Journal	American Journal of Human Genetics
Volume	55
Issue number	5
Publication status	Published - Nov 1994

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title = "Familial site-specific ovarian cancer is linked to BRCA1 on 17q12-21.",

abstract = "In a study of nine families with {"}site-specific{"} ovarian cancer (criterion: three or more cases of epithelial ovarian cancer and no cases of breast cancer diagnosed at age <50 years) we have obtained evidence of linkage to the breast-ovarian cancer susceptibility gene, BRCA1 on 17q12-21. If the risk of cancer in these families is assumed to be restricted to the ovary, the best estimate of the proportion of families linked to BRCA1 is .78 (95% confidence interval .32-1.0). If predisposition to both breast and ovarian cancer is assumed, the proportion linked is 1.0 (95% confidence interval .46-1.0). The linkage of familial site-specific ovarian cancer to BRCA1 indicates the possibility of predictive testing in such families; however, this is only appropriate in families where the evidence for linkage to BRCA1 is conclusive.",

author = "E Steichen-Gersdorf and Gallion, {H H} and D Ford and C Girodet and Easton, {D F} and DiCioccio, {R A} and G Evans and Ponder, {M A} and C Pye and S Mazoyer",

year = "1994",

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language = "English",

volume = "55",

journal = "American Journal of Human Genetics",

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TY - JOUR

T1 - Familial site-specific ovarian cancer is linked to BRCA1 on 17q12-21.

AU - Steichen-Gersdorf, E

AU - Gallion, H H

AU - Ford, D

AU - Girodet, C

AU - Easton, D F

AU - DiCioccio, R A

AU - Evans, G

AU - Ponder, M A

AU - Pye, C

AU - Mazoyer, S

PY - 1994/11

Y1 - 1994/11

N2 - In a study of nine families with "site-specific" ovarian cancer (criterion: three or more cases of epithelial ovarian cancer and no cases of breast cancer diagnosed at age <50 years) we have obtained evidence of linkage to the breast-ovarian cancer susceptibility gene, BRCA1 on 17q12-21. If the risk of cancer in these families is assumed to be restricted to the ovary, the best estimate of the proportion of families linked to BRCA1 is .78 (95% confidence interval .32-1.0). If predisposition to both breast and ovarian cancer is assumed, the proportion linked is 1.0 (95% confidence interval .46-1.0). The linkage of familial site-specific ovarian cancer to BRCA1 indicates the possibility of predictive testing in such families; however, this is only appropriate in families where the evidence for linkage to BRCA1 is conclusive.

AB - In a study of nine families with "site-specific" ovarian cancer (criterion: three or more cases of epithelial ovarian cancer and no cases of breast cancer diagnosed at age <50 years) we have obtained evidence of linkage to the breast-ovarian cancer susceptibility gene, BRCA1 on 17q12-21. If the risk of cancer in these families is assumed to be restricted to the ovary, the best estimate of the proportion of families linked to BRCA1 is .78 (95% confidence interval .32-1.0). If predisposition to both breast and ovarian cancer is assumed, the proportion linked is 1.0 (95% confidence interval .46-1.0). The linkage of familial site-specific ovarian cancer to BRCA1 indicates the possibility of predictive testing in such families; however, this is only appropriate in families where the evidence for linkage to BRCA1 is conclusive.

M3 - Article

C2 - 7977348

SN - 0002-9297

VL - 55

JO - American Journal of Human Genetics

JF - American Journal of Human Genetics

IS - 5

ER -

Familial site-specific ovarian cancer is linked to BRCA1 on 17q12-21.

Abstract

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