Here we show an interplay between the structures present in ionization tracks and nucleocapsid RNA structural biology, using fast ion beam inactivation of the severe acute respiratory syndrome coronavirus (SARS-CoV) virion as an example. This interplay could be a key factor in predicting dose-inactivation curves for high energy ion beam inactivation of virions. We also investigate the adaptation of wellestablished cross-section data derived from radiation interactions with water to the interactions involving the components of a virion, going beyond the density-scaling approximation developed previously. We conclude that solving one of the grand challenges of structural biology — the determination of RNA tertiary/quaternary structure — is linked to predicting ion-beam inactivation of viruses and that the two problems can be mutually informative. Indeed, our simulations show that fast ion beams have a key role to play in elucidating RNA tertiary/quaternary structure.
|Number of pages||13|
|Early online date||18 Apr 2022|
|Publication status||Published - 1 Jul 2022|
Research Beacons, Institutes and Platforms
- Dalton Nuclear Institute