FcγRIIIA-158V and rheumatoid arthritis: A confirmation study

A. W. Morgan, V. H. Keyte, S. J. Babbage, J. I. Robinson, F. Ponchel, J. H. Barrett, B. B. Bhakta, S. J. Bingham, M. H. Buch, P. G. Conaghan, A. Gough, M. Green, C. A. Lawson, C. T. Pease, A. F. Markham, W. E R Ollier, P. Emery, J. Worthington, J. D. Isaacs

Research output: Contribution to journalArticlepeer-review


Objectives. To develop a robust assay for genotyping the FcγRIIIA-158V/F polymorphism and to confirm the putative association between the FcγRIIIA-158V allele and rheumatoid arthritis (RA). Methods. This allelic association study examined the FcγRIIIA-158V/F polymorphism for association with RA. A novel single-stranded conformational polymorphism assay was used to genotype 828 RA patients and 581 controls from the UK. Results. The FcγRIIIA-158V allele was associated with both RA (P = 0.02) and nodules (P = 0.04). Individuals homozygous for this higher affinity allele had a significantly increased risk of RA (OR 1.53, 95% CI 1.08-2.18) and the development of nodules (OR 2.20, 95% CI 1.20-4.01). There was no evidence of an interaction with the shared epitope. Conclusions. We have developed a novel assay to genotype the FcγRIIIA-158F/V polymorphism and confirmed that homozygosity for the FcγRIIIA-158V allele is associated with UK Caucasian RA, particularly in those individuals with nodules, suggesting FcγRIIIA may play a role in determining disease severity or in the development of nodules per se.
Original languageEnglish
Pages (from-to)528-533
Number of pages5
Issue number4
Publication statusPublished - 1 Apr 2003


  • Fc gamma receptor
  • HLA-DRB1
  • Polymorphisms
  • Rheumatoid arthritis


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