FcγRIIIA-158V and rheumatoid arthritis: A confirmation study

A. W. Morgan; V. H. Keyte; S. J. Babbage; J. I. Robinson; F. Ponchel; J. H. Barrett; B. B. Bhakta; S. J. Bingham; M. H. Buch; P. G. Conaghan; A. Gough; M. Green; C. A. Lawson; C. T. Pease; A. F. Markham; W. E R Ollier; P. Emery; J. Worthington; J. D. Isaacs

doi:10.1093/rheumatology/keg169

FcγRIIIA-158V and rheumatoid arthritis: A confirmation study

A. W. Morgan, V. H. Keyte, S. J. Babbage, J. I. Robinson, F. Ponchel, J. H. Barrett, B. B. Bhakta, S. J. Bingham, M. H. Buch, P. G. Conaghan, A. Gough, M. Green, C. A. Lawson, C. T. Pease, A. F. Markham, W. E R Ollier, P. Emery, J. Worthington, J. D. Isaacs

Division of Musculoskeletal & Dermatological Sciences (L5)

Research output: Contribution to journal › Article › peer-review

Abstract

Objectives. To develop a robust assay for genotyping the FcγRIIIA-158V/F polymorphism and to confirm the putative association between the FcγRIIIA-158V allele and rheumatoid arthritis (RA). Methods. This allelic association study examined the FcγRIIIA-158V/F polymorphism for association with RA. A novel single-stranded conformational polymorphism assay was used to genotype 828 RA patients and 581 controls from the UK. Results. The FcγRIIIA-158V allele was associated with both RA (P = 0.02) and nodules (P = 0.04). Individuals homozygous for this higher affinity allele had a significantly increased risk of RA (OR 1.53, 95% CI 1.08-2.18) and the development of nodules (OR 2.20, 95% CI 1.20-4.01). There was no evidence of an interaction with the shared epitope. Conclusions. We have developed a novel assay to genotype the FcγRIIIA-158F/V polymorphism and confirmed that homozygosity for the FcγRIIIA-158V allele is associated with UK Caucasian RA, particularly in those individuals with nodules, suggesting FcγRIIIA may play a role in determining disease severity or in the development of nodules per se.

Original language	English
Pages (from-to)	528-533
Number of pages	5
Journal	Rheumatology
Volume	42
Issue number	4
DOIs	https://doi.org/10.1093/rheumatology/keg169
Publication status	Published - 1 Apr 2003

Keywords

Fc gamma receptor
HLA-DRB1
Polymorphisms
Rheumatoid arthritis

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Morgan, A. W., Keyte, V. H., Babbage, S. J., Robinson, J. I., Ponchel, F., Barrett, J. H., Bhakta, B. B., Bingham, S. J., Buch, M. H., Conaghan, P. G., Gough, A., Green, M., Lawson, C. A., Pease, C. T., Markham, A. F., Ollier, W. E. R., Emery, P., Worthington, J., & Isaacs, J. D. (2003). FcγRIIIA-158V and rheumatoid arthritis: A confirmation study. Rheumatology, 42(4), 528-533. https://doi.org/10.1093/rheumatology/keg169

@article{fc79bd45631544b8a37925099112ee8b,

title = "FcγRIIIA-158V and rheumatoid arthritis: A confirmation study",

abstract = "Objectives. To develop a robust assay for genotyping the FcγRIIIA-158V/F polymorphism and to confirm the putative association between the FcγRIIIA-158V allele and rheumatoid arthritis (RA). Methods. This allelic association study examined the FcγRIIIA-158V/F polymorphism for association with RA. A novel single-stranded conformational polymorphism assay was used to genotype 828 RA patients and 581 controls from the UK. Results. The FcγRIIIA-158V allele was associated with both RA (P = 0.02) and nodules (P = 0.04). Individuals homozygous for this higher affinity allele had a significantly increased risk of RA (OR 1.53, 95% CI 1.08-2.18) and the development of nodules (OR 2.20, 95% CI 1.20-4.01). There was no evidence of an interaction with the shared epitope. Conclusions. We have developed a novel assay to genotype the FcγRIIIA-158F/V polymorphism and confirmed that homozygosity for the FcγRIIIA-158V allele is associated with UK Caucasian RA, particularly in those individuals with nodules, suggesting FcγRIIIA may play a role in determining disease severity or in the development of nodules per se.",

keywords = "Fc gamma receptor, HLA-DRB1, Polymorphisms, Rheumatoid arthritis",

author = "Morgan, {A. W.} and Keyte, {V. H.} and Babbage, {S. J.} and Robinson, {J. I.} and F. Ponchel and Barrett, {J. H.} and Bhakta, {B. B.} and Bingham, {S. J.} and Buch, {M. H.} and Conaghan, {P. G.} and A. Gough and M. Green and Lawson, {C. A.} and Pease, {C. T.} and Markham, {A. F.} and Ollier, {W. E R} and P. Emery and J. Worthington and Isaacs, {J. D.}",

note = "UI - 22536502DA - 20030321IS - 1462-0324LA - engPT - Journal ArticleRN - 0 (HLA-DR Antigens)RN - 0 (Receptors, IgG)RN - 128338-86-3 (HLA-DRB1)SB - AIMSB - IM",

year = "2003",

month = apr,

day = "1",

doi = "10.1093/rheumatology/keg169",

language = "English",

volume = "42",

pages = "528--533",

journal = "Rheumatology",

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number = "4",

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Morgan, AW, Keyte, VH, Babbage, SJ, Robinson, JI, Ponchel, F, Barrett, JH, Bhakta, BB, Bingham, SJ, Buch, MH, Conaghan, PG, Gough, A, Green, M, Lawson, CA, Pease, CT, Markham, AF, Ollier, WER, Emery, P, Worthington, J & Isaacs, JD 2003, 'FcγRIIIA-158V and rheumatoid arthritis: A confirmation study', Rheumatology, vol. 42, no. 4, pp. 528-533. https://doi.org/10.1093/rheumatology/keg169

TY - JOUR

T1 - FcγRIIIA-158V and rheumatoid arthritis

T2 - A confirmation study

AU - Morgan, A. W.

AU - Keyte, V. H.

AU - Babbage, S. J.

AU - Robinson, J. I.

AU - Ponchel, F.

AU - Barrett, J. H.

AU - Bhakta, B. B.

AU - Bingham, S. J.

AU - Buch, M. H.

AU - Conaghan, P. G.

AU - Gough, A.

AU - Green, M.

AU - Lawson, C. A.

AU - Pease, C. T.

AU - Markham, A. F.

AU - Ollier, W. E R

AU - Emery, P.

AU - Worthington, J.

AU - Isaacs, J. D.

N1 - UI - 22536502DA - 20030321IS - 1462-0324LA - engPT - Journal ArticleRN - 0 (HLA-DR Antigens)RN - 0 (Receptors, IgG)RN - 128338-86-3 (HLA-DRB1)SB - AIMSB - IM

PY - 2003/4/1

Y1 - 2003/4/1

N2 - Objectives. To develop a robust assay for genotyping the FcγRIIIA-158V/F polymorphism and to confirm the putative association between the FcγRIIIA-158V allele and rheumatoid arthritis (RA). Methods. This allelic association study examined the FcγRIIIA-158V/F polymorphism for association with RA. A novel single-stranded conformational polymorphism assay was used to genotype 828 RA patients and 581 controls from the UK. Results. The FcγRIIIA-158V allele was associated with both RA (P = 0.02) and nodules (P = 0.04). Individuals homozygous for this higher affinity allele had a significantly increased risk of RA (OR 1.53, 95% CI 1.08-2.18) and the development of nodules (OR 2.20, 95% CI 1.20-4.01). There was no evidence of an interaction with the shared epitope. Conclusions. We have developed a novel assay to genotype the FcγRIIIA-158F/V polymorphism and confirmed that homozygosity for the FcγRIIIA-158V allele is associated with UK Caucasian RA, particularly in those individuals with nodules, suggesting FcγRIIIA may play a role in determining disease severity or in the development of nodules per se.

AB - Objectives. To develop a robust assay for genotyping the FcγRIIIA-158V/F polymorphism and to confirm the putative association between the FcγRIIIA-158V allele and rheumatoid arthritis (RA). Methods. This allelic association study examined the FcγRIIIA-158V/F polymorphism for association with RA. A novel single-stranded conformational polymorphism assay was used to genotype 828 RA patients and 581 controls from the UK. Results. The FcγRIIIA-158V allele was associated with both RA (P = 0.02) and nodules (P = 0.04). Individuals homozygous for this higher affinity allele had a significantly increased risk of RA (OR 1.53, 95% CI 1.08-2.18) and the development of nodules (OR 2.20, 95% CI 1.20-4.01). There was no evidence of an interaction with the shared epitope. Conclusions. We have developed a novel assay to genotype the FcγRIIIA-158F/V polymorphism and confirmed that homozygosity for the FcγRIIIA-158V allele is associated with UK Caucasian RA, particularly in those individuals with nodules, suggesting FcγRIIIA may play a role in determining disease severity or in the development of nodules per se.

KW - Fc gamma receptor

KW - HLA-DRB1

KW - Polymorphisms

KW - Rheumatoid arthritis

U2 - 10.1093/rheumatology/keg169

DO - 10.1093/rheumatology/keg169

M3 - Article

SN - 1462-0332

VL - 42

SP - 528

EP - 533

JO - Rheumatology

JF - Rheumatology

IS - 4

ER -

FcγRIIIA-158V and rheumatoid arthritis: A confirmation study

Abstract

Keywords

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