Feasibility of using optical coherence tomography to detect radiation-induced fibrosis and residual cancer extent after neoadjuvant chemo-radiation therapy: an ex vivo study

Pouya Jelvehgaran; Tanja Alderliesten; Giota Georgiou; Sybren L. Meijer; Paul R. Bloemen; Liudmila L. Kodach; Hanneke W. M. Van Laarhoven; Mark I. Van Berge Henegouwen; Maarten C. C. M. Hulshof; Coen R. N. Rasch; Ton G. Van Leeuwen; Johannes F. De Boer; Martijn De Bruin; Marcel Van Herk

doi:10.1364/BOE.9.004196

Feasibility of using optical coherence tomography to detect radiation-induced fibrosis and residual cancer extent after neoadjuvant chemo-radiation therapy: an ex vivo study

Pouya Jelvehgaran, Tanja Alderliesten, Giota Georgiou, Sybren L. Meijer, Paul R. Bloemen, Liudmila L. Kodach, Hanneke W. M. Van Laarhoven, Mark I. Van Berge Henegouwen, Maarten C. C. M. Hulshof, Coen R. N. Rasch, Ton G. Van Leeuwen, Johannes F. De Boer, Martijn De Bruin, Marcel Van Herk

Division of Cancer Sciences (L5)

Research output: Contribution to journal › Article › peer-review

Abstract

Treatment of resectable esophageal cancer includes neoadjuvant chemo-radiation therapy (nCRT) followed by esophagectomy in operable patients. High-risk surgery may have been avoided in patients with a pathological complete response (pCR). We investigated the feasibility of optical coherence tomography (OCT) to detect residual cancer and radiation-induced fibrosis in 10 esophageal cancer patients that underwent nCRT followed by esophagectomy. We compared our OCT findings with histopathology. Overall, OCT was able to differentiate between healthy tissue, fibrotic tissue, and residual cancer with a sensitivity and specificity of 79% and 67%, respectively. Hence, OCT has the potential to add to the assessment of a pCR.

Original language	English
Journal	Biomedical Optics Express
Volume	9
Issue number	9
Early online date	14 Aug 2018
DOIs	https://doi.org/10.1364/BOE.9.004196
Publication status	Published - 2018

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Manchester Cancer Research Centre

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https://www.osapublishing.org/abstract.cfm?URI=boe-9-9-4196

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Jelvehgaran, P., Alderliesten, T., Georgiou, G., Meijer, S. L., Bloemen, P. R., Kodach, L. L., Van Laarhoven, H. W. M., Van Berge Henegouwen, M. I., Hulshof, M. C. C. M., Rasch, C. R. N., Van Leeuwen, T. G., De Boer, J. F., De Bruin, M., & Van Herk, M. (2018). Feasibility of using optical coherence tomography to detect radiation-induced fibrosis and residual cancer extent after neoadjuvant chemo-radiation therapy: an ex vivo study. Biomedical Optics Express, 9(9). https://doi.org/10.1364/BOE.9.004196

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title = "Feasibility of using optical coherence tomography to detect radiation-induced fibrosis and residual cancer extent after neoadjuvant chemo-radiation therapy: an ex vivo study",

abstract = "Treatment of resectable esophageal cancer includes neoadjuvant chemo-radiation therapy (nCRT) followed by esophagectomy in operable patients. High-risk surgery may have been avoided in patients with a pathological complete response (pCR). We investigated the feasibility of optical coherence tomography (OCT) to detect residual cancer and radiation-induced fibrosis in 10 esophageal cancer patients that underwent nCRT followed by esophagectomy. We compared our OCT findings with histopathology. Overall, OCT was able to differentiate between healthy tissue, fibrotic tissue, and residual cancer with a sensitivity and specificity of 79% and 67%, respectively. Hence, OCT has the potential to add to the assessment of a pCR.",

author = "Pouya Jelvehgaran and Tanja Alderliesten and Giota Georgiou and Meijer, {Sybren L.} and Bloemen, {Paul R.} and Kodach, {Liudmila L.} and {Van Laarhoven}, {Hanneke W. M.} and {Van Berge Henegouwen}, {Mark I.} and Hulshof, {Maarten C. C. M.} and Rasch, {Coen R. N.} and {Van Leeuwen}, {Ton G.} and {De Boer}, {Johannes F.} and {De Bruin}, Martijn and {Van Herk}, Marcel",

year = "2018",

doi = "10.1364/BOE.9.004196",

language = "English",

volume = "9",

journal = "Biomedical Optics Express",

issn = "2156-7085",

publisher = "Optica Publishing Group (formerly OSA)",

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Jelvehgaran, P, Alderliesten, T, Georgiou, G, Meijer, SL, Bloemen, PR, Kodach, LL, Van Laarhoven, HWM, Van Berge Henegouwen, MI, Hulshof, MCCM, Rasch, CRN, Van Leeuwen, TG, De Boer, JF, De Bruin, M & Van Herk, M 2018, 'Feasibility of using optical coherence tomography to detect radiation-induced fibrosis and residual cancer extent after neoadjuvant chemo-radiation therapy: an ex vivo study', Biomedical Optics Express, vol. 9, no. 9. https://doi.org/10.1364/BOE.9.004196

TY - JOUR

T1 - Feasibility of using optical coherence tomography to detect radiation-induced fibrosis and residual cancer extent after neoadjuvant chemo-radiation therapy: an ex vivo study

AU - Jelvehgaran, Pouya

AU - Alderliesten, Tanja

AU - Georgiou, Giota

AU - Meijer, Sybren L.

AU - Bloemen, Paul R.

AU - Kodach, Liudmila L.

AU - Van Laarhoven, Hanneke W. M.

AU - Van Berge Henegouwen, Mark I.

AU - Hulshof, Maarten C. C. M.

AU - Rasch, Coen R. N.

AU - Van Leeuwen, Ton G.

AU - De Boer, Johannes F.

AU - De Bruin, Martijn

AU - Van Herk, Marcel

PY - 2018

Y1 - 2018

N2 - Treatment of resectable esophageal cancer includes neoadjuvant chemo-radiation therapy (nCRT) followed by esophagectomy in operable patients. High-risk surgery may have been avoided in patients with a pathological complete response (pCR). We investigated the feasibility of optical coherence tomography (OCT) to detect residual cancer and radiation-induced fibrosis in 10 esophageal cancer patients that underwent nCRT followed by esophagectomy. We compared our OCT findings with histopathology. Overall, OCT was able to differentiate between healthy tissue, fibrotic tissue, and residual cancer with a sensitivity and specificity of 79% and 67%, respectively. Hence, OCT has the potential to add to the assessment of a pCR.

AB - Treatment of resectable esophageal cancer includes neoadjuvant chemo-radiation therapy (nCRT) followed by esophagectomy in operable patients. High-risk surgery may have been avoided in patients with a pathological complete response (pCR). We investigated the feasibility of optical coherence tomography (OCT) to detect residual cancer and radiation-induced fibrosis in 10 esophageal cancer patients that underwent nCRT followed by esophagectomy. We compared our OCT findings with histopathology. Overall, OCT was able to differentiate between healthy tissue, fibrotic tissue, and residual cancer with a sensitivity and specificity of 79% and 67%, respectively. Hence, OCT has the potential to add to the assessment of a pCR.

U2 - 10.1364/BOE.9.004196

DO - 10.1364/BOE.9.004196

M3 - Article

SN - 2156-7085

VL - 9

JO - Biomedical Optics Express

JF - Biomedical Optics Express

IS - 9

ER -

Feasibility of using optical coherence tomography to detect radiation-induced fibrosis and residual cancer extent after neoadjuvant chemo-radiation therapy: an ex vivo study

Abstract

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