Feedback actions of locomotor activity to the circadian clock

Alun T L Hughes, Hugh D. Piggins

Research output: Contribution to journalArticlepeer-review

Abstract

The phase of the mammalian circadian system can be entrained to a range of environmental stimuli, or zeitgebers, including food availability and light. Further, locomotor activity can act as an entraining signal and represents a mechanism for an endogenous behavior to feedback and influence subsequent circadian function. This process involves a number of nuclei distributed across the brain stem, thalamus, and hypothalamus and ultimately alters SCN electrical and molecular function to induce phase shifts in the master circadian pacemaker. Locomotor activity feedback to the circadian system is effective across both nocturnal and diurnal species, including humans, and has recently been shown to improve circadian function in a mouse model with a weakened circadian system. This raises the possibility that exercise may be useful as a noninvasive treatment in cases of human circadian dysfunction including aging, shift work, transmeridian travel, and the blind. © 2012 Elsevier B.V.
Original languageEnglish
Pages (from-to)305-336
Number of pages31
JournalProgress in Brain Research
Volume199
DOIs
Publication statusPublished - 2012

Keywords

  • Aging
  • Arousal
  • Circadian
  • Clock gene
  • Exercise
  • Locomotor activity
  • NPY
  • Serotonin
  • Suprachiasmatic
  • VIP
  • Wheel-running

Fingerprint

Dive into the research topics of 'Feedback actions of locomotor activity to the circadian clock'. Together they form a unique fingerprint.

Cite this