TY - GEN
T1 - Femoral strength prediction using a 3D reconstruction method from Dual-energy X-ray Absorptiometry
AU - Humbert, Ludovic
AU - Whitmarsh, Tristan
AU - Fritscher, Karl
AU - Del Río Barquero, Luis Miguel
AU - Eckstein, Felix
AU - Link, Thomas
AU - Schubert, Rainer
AU - Frangi, Alejandro F.
PY - 2012
Y1 - 2012
N2 - Femoral strength is estimated in clinical routine from 2D Dual-energy X-rays Absorptiometry (DXA). In this study, a new pipeline for femoral strength prediction from DXA images is presented, using a 3D reconstruction method of the shape and the Bone Mineral Density (BMD) distribution and a regression analysis based on partial least squares. A database of 90 proximal femoral cadaveric specimens, that were previously imaged and tested to measure their fracture load, was used to develop and to validate the method. The proposed pipeline resulted in a correlation coefficient of 0.85 between predicted and measured fracture load, while a regression using 2D BMD measurements from DXA resulted in a correlation coefficient of 0.77. With an improved femoral strength prediction from DXA images, this method opens interesting translational perspectives in clinics for a better diagnosis of osteoporosis and fracture risk prediction.
AB - Femoral strength is estimated in clinical routine from 2D Dual-energy X-rays Absorptiometry (DXA). In this study, a new pipeline for femoral strength prediction from DXA images is presented, using a 3D reconstruction method of the shape and the Bone Mineral Density (BMD) distribution and a regression analysis based on partial least squares. A database of 90 proximal femoral cadaveric specimens, that were previously imaged and tested to measure their fracture load, was used to develop and to validate the method. The proposed pipeline resulted in a correlation coefficient of 0.85 between predicted and measured fracture load, while a regression using 2D BMD measurements from DXA resulted in a correlation coefficient of 0.77. With an improved femoral strength prediction from DXA images, this method opens interesting translational perspectives in clinics for a better diagnosis of osteoporosis and fracture risk prediction.
KW - 3D Reconstruction
KW - Femoral strength
KW - Osteoporosis
KW - Partial Least Square Regression
KW - Statistical Model
UR - http://www.scopus.com/inward/record.url?scp=84864831168&partnerID=8YFLogxK
U2 - 10.1109/ISBI.2012.6235844
DO - 10.1109/ISBI.2012.6235844
M3 - Conference contribution
AN - SCOPUS:84864831168
SN - 9781457718588
T3 - Proceedings - International Symposium on Biomedical Imaging
SP - 1451
EP - 1454
BT - 2012 9th IEEE International Symposium on Biomedical Imaging
T2 - 2012 9th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2012
Y2 - 2 May 2012 through 5 May 2012
ER -