Fetal fibronectin as a predictor of spontaneous preterm labour in asymptomatic women with a cervical cerclage

KE Duhig, M Chandiramani, Paul T. Seed, AL Briley, AP Kenyon, Andrew H Shennan

Research output: Contribution to journalArticlepeer-review

Abstract

Objective To assess the accuracy of fetal fibronectin (fFN) testing for prediction of preterm labour in asymptomatic high-risk women with a cervical cerclage.

Design Retrospective observational study.

Setting United Kingdom.

Population Nine hundred and ten asymptomatic women at high-risk of Preterm birth referred to specialist antenatal clinics and undergoing fFN testing between November 1997 and December 2007.

Methods Women had fFN tests taken between 23+0 and 27+6 weeks’ gestation, on one or more occasions.

Main outcome measures Sensitivity, specificity, positive predictive values and negative predictive values of fFN testing for predicting delivery <30 and <37 weeks were compared in those with and without cerclage.

Results For delivery <30 weeks’ gestation, the specificity of fFN testing was significantly lower in women with cervical cerclage (77% vs 90%; P ≤ 0.00001). The sensitivity of the test was similar between the groups (78.6 (no-cerclage) vs 60% (cerclage); P > 0.4). The negative predictive value of the fFN test for delivery <30 weeks was high in both groups (>98%).

Conclusions Asymptomatic high-risk women with cerclage in situ are more likely to have a false positive fFN test. The negative predictive value is similar.
Original languageEnglish
Pages (from-to)799-803
Number of pages5
JournalBJOG : an international journal of obstetrics and gynaecology
Volume116
Issue number6
DOIs
Publication statusPublished - 23 Apr 2009

Keywords

  • Cerclage
  • fetal fibronectin
  • sensitivity and specificity
  • spontaneous preterm birth

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