FGF receptor genes and breast cancer susceptibility: results from the Breast Cancer Association Consortium

D Agarwal; S Pineda; K Michailidou; J Herranz; G Pita; L T Moreno; M R Alonso; J Dennis; Q Wang; M K Bolla; K B Meyer; P Menendez-Rodriguez; D Hardisson; M Mendiola; A Gonzalez-Neira; A Lindblom; S Margolin; A Swerdlow; A Ashworth; N Orr; M Jones; K Matsuo; H Ito; H Iwata; N Kondo; M Hartman; M Hui; W Y Lim; P T Iau; E Sawyer; I Tomlinson; M Kerin; N Miller; D Kang; J Choi; S K Park; D Noh; J L Hopper; D F Schmidt; E Makalic; M C Southey; S H Teo; C H Yip; K Sivanandan; W Tay; H Brauch; T Bruning; U Hamann; A M Dunning; M Shah; I L Andrulis; J A Knight; G Glendon; S Tchatchou; M K Schmidt; A Broeks; E H Rosenberg; L J van't Veer; P A Fasching; S P Renner; A B Ekici; M W Beckmann; C Shen; C Hsiung; J Yu; M Hou; W Blot; Q Cai; A H Wu; C Tseng; D Van Den Berg; D O Stram; A Cox; I W Brock; M W Reed; K Muir; A Lophatananon; S Stewart-Brown; P Siriwanarangsan; W Zheng; S Deming-Halverson; M J Shrubsole; J Long; X Shu; W Lu; Y Gao; B Zhang; P Radice; P Peterlongo; S Manoukian; F Mariette; S Sangrajrang; J McKay; F J Couch; A E Toland; D Yannoukakos; O Fletcher; N Johnson; I dos Santos Silva; J Peto; F Marme; B Burwinkel; P Guenel; T Truong; M Sanchez; C Mulot; S E Bojesen; B G Nordestgaard; H Flyer; H Brenner; A K Dieffenbach; V Arndt; C Stegmaier; A Mannermaa; V Kataja; V Kosma; J M Hartikainen; D Lambrechts; B T Yesilyurt; G Floris; K Leunen; J Chang-Claude; A Rudolph; P Seibold; D Flesch-Janys; X Wang; J E Olson; C Vachon; K Purrington; G G Giles; G Severi; L Baglietto; C A Haiman; B E Henderson; F Schumacher; L L Marchand; J Simard; M Dumont; M S Goldberg; F Labreche; R Winqvist; K Pylkas; A Jukkola-Vuorinen; M Grip; P Devilee; R A Tollenaar; C Seynaeve; M Garcia-Closas; S J Chanock; J Lissowska; J D Figueroa; K Czene; M Eriksson; K Humphreys; H Darabi; M J Hooning; M Kriege; J M Collee; M Tilanus-Linthorst; J Li; A Jakubowska; J Lubinski; K Jaworska-Bieniek; K Durda; H Nevanlinna; T A Muranen; K Aittomaki; C Blomqvist; N Bogdanova; T Dork; P Hall; G Chenevix-Trench; D F Easton; P D Pharroah; J I Arias-Perez; P Zamora; J Benitez; R L Milne

doi:10.1038/bjc.2013.769

FGF receptor genes and breast cancer susceptibility: results from the Breast Cancer Association Consortium

D Agarwal, S Pineda, K Michailidou, J Herranz, G Pita, L T Moreno, M R Alonso, J Dennis, Q Wang, M K Bolla, K B Meyer, P Menendez-Rodriguez, D Hardisson, M Mendiola, A Gonzalez-Neira, A Lindblom, S Margolin, A Swerdlow, A Ashworth, N OrrM Jones, K Matsuo, H Ito, H Iwata, N Kondo, M Hartman, M Hui, W Y Lim, P T Iau, E Sawyer, I Tomlinson, M Kerin, N Miller, D Kang, J Choi, S K Park, D Noh, J L Hopper, D F Schmidt, E Makalic, M C Southey, S H Teo, C H Yip, K Sivanandan, W Tay, H Brauch, T Bruning, U Hamann, A M Dunning, M Shah, I L Andrulis, J A Knight, G Glendon, S Tchatchou, M K Schmidt, A Broeks, E H Rosenberg, L J van't Veer, P A Fasching, S P Renner, A B Ekici, M W Beckmann, C Shen, C Hsiung, J Yu, M Hou, W Blot, Q Cai, A H Wu, C Tseng, D Van Den Berg, D O Stram, A Cox, I W Brock, M W Reed, K Muir, A Lophatananon, S Stewart-Brown, P Siriwanarangsan, W Zheng, S Deming-Halverson, M J Shrubsole, J Long, X Shu, W Lu, Y Gao, B Zhang, P Radice, P Peterlongo, S Manoukian, F Mariette, S Sangrajrang, J McKay, F J Couch, A E Toland, D Yannoukakos, O Fletcher, N Johnson, I dos Santos Silva, J Peto, F Marme, B Burwinkel, P Guenel, T Truong, M Sanchez, C Mulot, S E Bojesen, B G Nordestgaard, H Flyer, H Brenner, A K Dieffenbach, V Arndt, C Stegmaier, A Mannermaa, V Kataja, V Kosma, J M Hartikainen, D Lambrechts, B T Yesilyurt, G Floris, K Leunen, J Chang-Claude, A Rudolph, P Seibold, D Flesch-Janys, X Wang, J E Olson, C Vachon, K Purrington, G G Giles, G Severi, L Baglietto, C A Haiman, B E Henderson, F Schumacher, L L Marchand, J Simard, M Dumont, M S Goldberg, F Labreche, R Winqvist, K Pylkas, A Jukkola-Vuorinen, M Grip, P Devilee, R A Tollenaar, C Seynaeve, M Garcia-Closas, S J Chanock, J Lissowska, J D Figueroa, K Czene, M Eriksson, K Humphreys, H Darabi, M J Hooning, M Kriege, J M Collee, M Tilanus-Linthorst, J Li, A Jakubowska, J Lubinski, K Jaworska-Bieniek, K Durda, H Nevanlinna, T A Muranen, K Aittomaki, C Blomqvist, N Bogdanova, T Dork, P Hall, G Chenevix-Trench, D F Easton, P D Pharroah, J I Arias-Perez, P Zamora, J Benitez, R L Milne

Research output: Contribution to journal › Article › peer-review

Abstract

Background:Breast cancer is one of the most common malignancies in women. Genome-wide association studies have identified FGFR2 as a breast cancer susceptibility gene. Common variation in other fibroblast growth factor (FGF) receptors might also modify risk. We tested this hypothesis by studying genotyped single-nucleotide polymorphisms (SNPs) and imputed SNPs in FGFR1, FGFR3, FGFR4 and FGFRL1 in the Breast Cancer Association Consortium.Methods:Data were combined from 49 studies, including 53 835 cases and 50 156 controls, of which 89 050 (46 450 cases and 42 600 controls) were of European ancestry, 12 893 (6269 cases and 6624 controls) of Asian and 2048 (1116 cases and 932 controls) of African ancestry. Associations with risk of breast cancer, overall and by disease sub-type, were assessed using unconditional logistic regression.Results:Little evidence of association with breast cancer risk was observed for SNPs in the FGF receptor genes. The strongest evidence in European women was for rs743682 in FGFR3; the estimated per-allele odds ratio was 1.05 (95% confidence interval=1.02-1.09, P=0.0020), which is substantially lower than that observed for SNPs in FGFR2.Conclusion:Our results suggest that common variants in the other FGF receptors are not associated with risk of breast cancer to the degree observed for FGFR2.

Original language	English
Pages (from-to)	1088-100
Number of pages	987
Journal	Br J Cancer
Volume	110
Issue number	4
DOIs	https://doi.org/10.1038/bjc.2013.769
Publication status	Published - 2014

Keywords

Breast Neoplasms/ genetics
Case-Control Studies
Female
Genetic Predisposition to Disease
Genetic Variation
Genome-Wide Association Study
Genotype
Humans
Polymorphism, Single Nucleotide/genetics
Receptor, Fibroblast Growth Factor, Type 1/genetics
Receptor, Fibroblast Growth Factor, Type 2/ genetics
Receptor, Fibroblast Growth Factor, Type 3/genetics
Receptor, Fibroblast Growth Factor, Type 4/genetics
Receptor, Fibroblast Growth Factor, Type 5/genetics

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1038/bjc.2013.769

Cite this

Agarwal, D., Pineda, S., Michailidou, K., Herranz, J., Pita, G., Moreno, L. T., Alonso, M. R., Dennis, J., Wang, Q., Bolla, M. K., Meyer, K. B., Menendez-Rodriguez, P., Hardisson, D., Mendiola, M., Gonzalez-Neira, A., Lindblom, A., Margolin, S., Swerdlow, A., Ashworth, A., ... Milne, R. L. (2014). FGF receptor genes and breast cancer susceptibility: results from the Breast Cancer Association Consortium. Br J Cancer, 110(4), 1088-100. https://doi.org/10.1038/bjc.2013.769

@article{8f9d2a65e355435abdad9cdf13b98bbe,

title = "FGF receptor genes and breast cancer susceptibility: results from the Breast Cancer Association Consortium",

abstract = "Background:Breast cancer is one of the most common malignancies in women. Genome-wide association studies have identified FGFR2 as a breast cancer susceptibility gene. Common variation in other fibroblast growth factor (FGF) receptors might also modify risk. We tested this hypothesis by studying genotyped single-nucleotide polymorphisms (SNPs) and imputed SNPs in FGFR1, FGFR3, FGFR4 and FGFRL1 in the Breast Cancer Association Consortium.Methods:Data were combined from 49 studies, including 53 835 cases and 50 156 controls, of which 89 050 (46 450 cases and 42 600 controls) were of European ancestry, 12 893 (6269 cases and 6624 controls) of Asian and 2048 (1116 cases and 932 controls) of African ancestry. Associations with risk of breast cancer, overall and by disease sub-type, were assessed using unconditional logistic regression.Results:Little evidence of association with breast cancer risk was observed for SNPs in the FGF receptor genes. The strongest evidence in European women was for rs743682 in FGFR3; the estimated per-allele odds ratio was 1.05 (95% confidence interval=1.02-1.09, P=0.0020), which is substantially lower than that observed for SNPs in FGFR2.Conclusion:Our results suggest that common variants in the other FGF receptors are not associated with risk of breast cancer to the degree observed for FGFR2.",

keywords = "Breast Neoplasms/ genetics, Case-Control Studies, Female, Genetic Predisposition to Disease, Genetic Variation, Genome-Wide Association Study, Genotype, Humans, Polymorphism, Single Nucleotide/genetics, Receptor, Fibroblast Growth Factor, Type 1/genetics, Receptor, Fibroblast Growth Factor, Type 2/ genetics, Receptor, Fibroblast Growth Factor, Type 3/genetics, Receptor, Fibroblast Growth Factor, Type 4/genetics, Receptor, Fibroblast Growth Factor, Type 5/genetics",

author = "D Agarwal and S Pineda and K Michailidou and J Herranz and G Pita and Moreno, {L T} and Alonso, {M R} and J Dennis and Q Wang and Bolla, {M K} and Meyer, {K B} and P Menendez-Rodriguez and D Hardisson and M Mendiola and A Gonzalez-Neira and A Lindblom and S Margolin and A Swerdlow and A Ashworth and N Orr and M Jones and K Matsuo and H Ito and H Iwata and N Kondo and M Hartman and M Hui and Lim, {W Y} and Iau, {P T} and E Sawyer and I Tomlinson and M Kerin and N Miller and D Kang and J Choi and Park, {S K} and D Noh and Hopper, {J L} and Schmidt, {D F} and E Makalic and Southey, {M C} and Teo, {S H} and Yip, {C H} and K Sivanandan and W Tay and H Brauch and T Bruning and U Hamann and Dunning, {A M} and M Shah and Andrulis, {I L} and Knight, {J A} and G Glendon and S Tchatchou and Schmidt, {M K} and A Broeks and Rosenberg, {E H} and {van't Veer}, {L J} and Fasching, {P A} and Renner, {S P} and Ekici, {A B} and Beckmann, {M W} and C Shen and C Hsiung and J Yu and M Hou and W Blot and Q Cai and Wu, {A H} and C Tseng and {Van Den Berg}, D and Stram, {D O} and A Cox and Brock, {I W} and Reed, {M W} and K Muir and A Lophatananon and S Stewart-Brown and P Siriwanarangsan and W Zheng and S Deming-Halverson and Shrubsole, {M J} and J Long and X Shu and W Lu and Y Gao and B Zhang and P Radice and P Peterlongo and S Manoukian and F Mariette and S Sangrajrang and J McKay and Couch, {F J} and Toland, {A E} and D Yannoukakos and O Fletcher and N Johnson and {dos Santos Silva}, I and J Peto and F Marme and B Burwinkel and P Guenel and T Truong and M Sanchez and C Mulot and Bojesen, {S E} and Nordestgaard, {B G} and H Flyer and H Brenner and Dieffenbach, {A K} and V Arndt and C Stegmaier and A Mannermaa and V Kataja and V Kosma and Hartikainen, {J M} and D Lambrechts and Yesilyurt, {B T} and G Floris and K Leunen and J Chang-Claude and A Rudolph and P Seibold and D Flesch-Janys and X Wang and Olson, {J E} and C Vachon and K Purrington and Giles, {G G} and G Severi and L Baglietto and Haiman, {C A} and Henderson, {B E} and F Schumacher and Marchand, {L L} and J Simard and M Dumont and Goldberg, {M S} and F Labreche and R Winqvist and K Pylkas and A Jukkola-Vuorinen and M Grip and P Devilee and Tollenaar, {R A} and C Seynaeve and M Garcia-Closas and Chanock, {S J} and J Lissowska and Figueroa, {J D} and K Czene and M Eriksson and K Humphreys and H Darabi and Hooning, {M J} and M Kriege and Collee, {J M} and M Tilanus-Linthorst and J Li and A Jakubowska and J Lubinski and K Jaworska-Bieniek and K Durda and H Nevanlinna and Muranen, {T A} and K Aittomaki and C Blomqvist and N Bogdanova and T Dork and P Hall and G Chenevix-Trench and Easton, {D F} and Pharroah, {P D} and Arias-Perez, {J I} and P Zamora and J Benitez and Milne, {R L}",

note = "Agarwal, D Pineda, S Michailidou, K Herranz, J Pita, G Moreno, L T Alonso, M R Dennis, J Wang, Q Bolla, M K Meyer, K B Menendez-Rodriguez, P Hardisson, D Mendiola, M Gonzalez-Neira, A Lindblom, A Margolin, S Swerdlow, A Ashworth, A Orr, N Jones, M Matsuo, K Ito, H Iwata, H Kondo, N kConFab Investigators Australian Ovarian Cancer Study Group Hartman, M Hui, M Lim, W Y Iau, P T -C Sawyer, E Tomlinson, I Kerin, M Miller, N Kang, D Choi, J -Y Park, S K Noh, D -Y Hopper, J L Schmidt, D F Makalic, E Southey, M C Teo, S H Yip, C H Sivanandan, K Tay, W -T Brauch, H Bruning, T Hamann, U GENICA Network Dunning, A M Shah, M Andrulis, I L Knight, J A Glendon, G Tchatchou, S Schmidt, M K Broeks, A Rosenberg, E H van't Veer, L J Fasching, P A Renner, S P Ekici, A B Beckmann, M W Shen, C -Y Hsiung, C -N Yu, J -C Hou, M -F Blot, W Cai, Q Wu, A H Tseng, C -C Van Den Berg, D Stram, D O Cox, A Brock, I W Reed, M W R Muir, K Lophatananon, A Stewart-Brown, S Siriwanarangsan, P Zheng, W Deming-Halverson, S Shrubsole, M J Long, J Shu, X -O Lu, W Gao, Y -T Zhang, B Radice, P Peterlongo, P Manoukian, S Mariette, F Sangrajrang, S McKay, J Couch, F J Toland, A E Tnbcc Yannoukakos, D Fletcher, O Johnson, N dos Santos Silva, I Peto, J Marme, F Burwinkel, B Guenel, P Truong, T Sanchez, M Mulot, C Bojesen, S E Nordestgaard, B G Flyer, H Brenner, H Dieffenbach, A K Arndt, V Stegmaier, C Mannermaa, A Kataja, V Kosma, V -M Hartikainen, J M Lambrechts, D Yesilyurt, B T Floris, G Leunen, K Chang-Claude, J Rudolph, A Seibold, P Flesch-Janys, D Wang, X Olson, J E Vachon, C Purrington, K Giles, G G Severi, G Baglietto, L Haiman, C A Henderson, B E Schumacher, F Marchand, L Le Simard, J Dumont, M Goldberg, M S Labreche, F Winqvist, R Pylkas, K Jukkola-Vuorinen, A Grip, M Devilee, P Tollenaar, R A E M Seynaeve, C Garcia-Closas, M Chanock, S J Lissowska, J Figueroa, J D Czene, K Eriksson, M Humphreys, K Darabi, H Hooning, M J Kriege, M Collee, J M Tilanus-Linthorst, M Li, J Jakubowska, A Lubinski, J Jaworska-Bieniek, K Durda, K Nevanlinna, H Muranen, T A Aittomaki, K Blomqvist, C Bogdanova, N Dork, T Hall, P Chenevix-Trench, G Easton, D F Pharroah, P D P Arias-Perez, J I Zamora, P Benitez, J Milne, R L 1U19 CA148065/CA/NCI NIH HHS/United States 1U19 CA148112/CA/NCI NIH HHS/United States C1287/A10118/Cancer Research UK/United Kingdom C1287/A10710/Cancer Research UK/United Kingdom C1287/A12014/Cancer Research UK/United Kingdom C490/A10124/Cancer Research UK/United Kingdom CA098758/CA/NCI NIH HHS/United States CA128978/CA/NCI NIH HHS/United States CA132839/CA/NCI NIH HHS/United States CA54281/CA/NCI NIH HHS/United States CA63464/CA/NCI NIH HHS/United States CRN-87521/Canadian Institutes of Health Research/Canada P30 CA68485/CA/NCI NIH HHS/United States P50 CA116201/CA/NCI NIH HHS/United States R01 CA092447/CA/NCI NIH HHS/United States R01 CA122340/CA/NCI NIH HHS/United States R01 CA128978/CA/NCI NIH HHS/United States R01CA100374/CA/NCI NIH HHS/United States R01CA148667/CA/NCI NIH HHS/United States R01CA64277/CA/NCI NIH HHS/United States R37CA70867/CA/NCI NIH HHS/United States U19 CA148537/CA/NCI NIH HHS/United States UM1 CA164920/CA/NCI NIH HHS/United States Multicenter Study Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. England British journal of cancer Br J Cancer. 2014 Feb 18;110(4):1088-100. doi: 10.1038/bjc.2013.769.",

year = "2014",

doi = "10.1038/bjc.2013.769",

language = "English",

volume = "110",

pages = "1088--100",

journal = "Br J Cancer",

issn = "1532-1827",

publisher = "Springer Nature",

number = "4",

}

Agarwal, D, Pineda, S, Michailidou, K, Herranz, J, Pita, G, Moreno, LT, Alonso, MR, Dennis, J, Wang, Q, Bolla, MK, Meyer, KB, Menendez-Rodriguez, P, Hardisson, D, Mendiola, M, Gonzalez-Neira, A, Lindblom, A, Margolin, S, Swerdlow, A, Ashworth, A, Orr, N, Jones, M, Matsuo, K, Ito, H, Iwata, H, Kondo, N, Hartman, M, Hui, M, Lim, WY, Iau, PT, Sawyer, E, Tomlinson, I, Kerin, M, Miller, N, Kang, D, Choi, J, Park, SK, Noh, D, Hopper, JL, Schmidt, DF, Makalic, E, Southey, MC, Teo, SH, Yip, CH, Sivanandan, K, Tay, W, Brauch, H, Bruning, T, Hamann, U, Dunning, AM, Shah, M, Andrulis, IL, Knight, JA, Glendon, G, Tchatchou, S, Schmidt, MK, Broeks, A, Rosenberg, EH, van't Veer, LJ, Fasching, PA, Renner, SP, Ekici, AB, Beckmann, MW, Shen, C, Hsiung, C, Yu, J, Hou, M, Blot, W, Cai, Q, Wu, AH, Tseng, C, Van Den Berg, D, Stram, DO, Cox, A, Brock, IW, Reed, MW, Muir, K, Lophatananon, A, Stewart-Brown, S, Siriwanarangsan, P, Zheng, W, Deming-Halverson, S, Shrubsole, MJ, Long, J, Shu, X, Lu, W, Gao, Y, Zhang, B, Radice, P, Peterlongo, P, Manoukian, S, Mariette, F, Sangrajrang, S, McKay, J, Couch, FJ, Toland, AE, Yannoukakos, D, Fletcher, O, Johnson, N, dos Santos Silva, I, Peto, J, Marme, F, Burwinkel, B, Guenel, P, Truong, T, Sanchez, M, Mulot, C, Bojesen, SE, Nordestgaard, BG, Flyer, H, Brenner, H, Dieffenbach, AK, Arndt, V, Stegmaier, C, Mannermaa, A, Kataja, V, Kosma, V, Hartikainen, JM, Lambrechts, D, Yesilyurt, BT, Floris, G, Leunen, K, Chang-Claude, J, Rudolph, A, Seibold, P, Flesch-Janys, D, Wang, X, Olson, JE, Vachon, C, Purrington, K, Giles, GG, Severi, G, Baglietto, L, Haiman, CA, Henderson, BE, Schumacher, F, Marchand, LL, Simard, J, Dumont, M, Goldberg, MS, Labreche, F, Winqvist, R, Pylkas, K, Jukkola-Vuorinen, A, Grip, M, Devilee, P, Tollenaar, RA, Seynaeve, C, Garcia-Closas, M, Chanock, SJ, Lissowska, J, Figueroa, JD, Czene, K, Eriksson, M, Humphreys, K, Darabi, H, Hooning, MJ, Kriege, M, Collee, JM, Tilanus-Linthorst, M, Li, J, Jakubowska, A, Lubinski, J, Jaworska-Bieniek, K, Durda, K, Nevanlinna, H, Muranen, TA, Aittomaki, K, Blomqvist, C, Bogdanova, N, Dork, T, Hall, P, Chenevix-Trench, G, Easton, DF, Pharroah, PD, Arias-Perez, JI, Zamora, P, Benitez, J & Milne, RL 2014, 'FGF receptor genes and breast cancer susceptibility: results from the Breast Cancer Association Consortium', Br J Cancer, vol. 110, no. 4, pp. 1088-100. https://doi.org/10.1038/bjc.2013.769

TY - JOUR

T1 - FGF receptor genes and breast cancer susceptibility: results from the Breast Cancer Association Consortium

AU - Agarwal, D

AU - Pineda, S

AU - Michailidou, K

AU - Herranz, J

AU - Pita, G

AU - Moreno, L T

AU - Alonso, M R

AU - Dennis, J

AU - Wang, Q

AU - Bolla, M K

AU - Meyer, K B

AU - Menendez-Rodriguez, P

AU - Hardisson, D

AU - Mendiola, M

AU - Gonzalez-Neira, A

AU - Lindblom, A

AU - Margolin, S

AU - Swerdlow, A

AU - Ashworth, A

AU - Orr, N

AU - Jones, M

AU - Matsuo, K

AU - Ito, H

AU - Iwata, H

AU - Kondo, N

AU - Hartman, M

AU - Hui, M

AU - Lim, W Y

AU - Iau, P T

AU - Sawyer, E

AU - Tomlinson, I

AU - Kerin, M

AU - Miller, N

AU - Kang, D

AU - Choi, J

AU - Park, S K

AU - Noh, D

AU - Hopper, J L

AU - Schmidt, D F

AU - Makalic, E

AU - Southey, M C

AU - Teo, S H

AU - Yip, C H

AU - Sivanandan, K

AU - Tay, W

AU - Brauch, H

AU - Bruning, T

AU - Hamann, U

AU - Dunning, A M

AU - Shah, M

AU - Andrulis, I L

AU - Knight, J A

AU - Glendon, G

AU - Tchatchou, S

AU - Schmidt, M K

AU - Broeks, A

AU - Rosenberg, E H

AU - van't Veer, L J

AU - Fasching, P A

AU - Renner, S P

AU - Ekici, A B

AU - Beckmann, M W

AU - Shen, C

AU - Hsiung, C

AU - Yu, J

AU - Hou, M

AU - Blot, W

AU - Cai, Q

AU - Wu, A H

AU - Tseng, C

AU - Van Den Berg, D

AU - Stram, D O

AU - Cox, A

AU - Brock, I W

AU - Reed, M W

AU - Muir, K

AU - Lophatananon, A

AU - Stewart-Brown, S

AU - Siriwanarangsan, P

AU - Zheng, W

AU - Deming-Halverson, S

AU - Shrubsole, M J

AU - Long, J

AU - Shu, X

AU - Lu, W

AU - Gao, Y

AU - Zhang, B

AU - Radice, P

AU - Peterlongo, P

AU - Manoukian, S

AU - Mariette, F

AU - Sangrajrang, S

AU - McKay, J

AU - Couch, F J

AU - Toland, A E

AU - Yannoukakos, D

AU - Fletcher, O

AU - Johnson, N

AU - dos Santos Silva, I

AU - Peto, J

AU - Marme, F

AU - Burwinkel, B

AU - Guenel, P

AU - Truong, T

AU - Sanchez, M

AU - Mulot, C

AU - Bojesen, S E

AU - Nordestgaard, B G

AU - Flyer, H

AU - Brenner, H

AU - Dieffenbach, A K

AU - Arndt, V

AU - Stegmaier, C

AU - Mannermaa, A

AU - Kataja, V

AU - Kosma, V

AU - Hartikainen, J M

AU - Lambrechts, D

AU - Yesilyurt, B T

AU - Floris, G

AU - Leunen, K

AU - Chang-Claude, J

AU - Rudolph, A

AU - Seibold, P

AU - Flesch-Janys, D

AU - Wang, X

AU - Olson, J E

AU - Vachon, C

AU - Purrington, K

AU - Giles, G G

AU - Severi, G

AU - Baglietto, L

AU - Haiman, C A

AU - Henderson, B E

AU - Schumacher, F

AU - Marchand, L L

AU - Simard, J

AU - Dumont, M

AU - Goldberg, M S

AU - Labreche, F

AU - Winqvist, R

AU - Pylkas, K

AU - Jukkola-Vuorinen, A

AU - Grip, M

AU - Devilee, P

AU - Tollenaar, R A

AU - Seynaeve, C

AU - Garcia-Closas, M

AU - Chanock, S J

AU - Lissowska, J

AU - Figueroa, J D

AU - Czene, K

AU - Eriksson, M

AU - Humphreys, K

AU - Darabi, H

AU - Hooning, M J

AU - Kriege, M

AU - Collee, J M

AU - Tilanus-Linthorst, M

AU - Li, J

AU - Jakubowska, A

AU - Lubinski, J

AU - Jaworska-Bieniek, K

AU - Durda, K

AU - Nevanlinna, H

AU - Muranen, T A

AU - Aittomaki, K

AU - Blomqvist, C

AU - Bogdanova, N

AU - Dork, T

AU - Hall, P

AU - Chenevix-Trench, G

AU - Easton, D F

AU - Pharroah, P D

AU - Arias-Perez, J I

AU - Zamora, P

AU - Benitez, J

AU - Milne, R L

N1 - Agarwal, D Pineda, S Michailidou, K Herranz, J Pita, G Moreno, L T Alonso, M R Dennis, J Wang, Q Bolla, M K Meyer, K B Menendez-Rodriguez, P Hardisson, D Mendiola, M Gonzalez-Neira, A Lindblom, A Margolin, S Swerdlow, A Ashworth, A Orr, N Jones, M Matsuo, K Ito, H Iwata, H Kondo, N kConFab Investigators Australian Ovarian Cancer Study Group Hartman, M Hui, M Lim, W Y Iau, P T -C Sawyer, E Tomlinson, I Kerin, M Miller, N Kang, D Choi, J -Y Park, S K Noh, D -Y Hopper, J L Schmidt, D F Makalic, E Southey, M C Teo, S H Yip, C H Sivanandan, K Tay, W -T Brauch, H Bruning, T Hamann, U GENICA Network Dunning, A M Shah, M Andrulis, I L Knight, J A Glendon, G Tchatchou, S Schmidt, M K Broeks, A Rosenberg, E H van't Veer, L J Fasching, P A Renner, S P Ekici, A B Beckmann, M W Shen, C -Y Hsiung, C -N Yu, J -C Hou, M -F Blot, W Cai, Q Wu, A H Tseng, C -C Van Den Berg, D Stram, D O Cox, A Brock, I W Reed, M W R Muir, K Lophatananon, A Stewart-Brown, S Siriwanarangsan, P Zheng, W Deming-Halverson, S Shrubsole, M J Long, J Shu, X -O Lu, W Gao, Y -T Zhang, B Radice, P Peterlongo, P Manoukian, S Mariette, F Sangrajrang, S McKay, J Couch, F J Toland, A E Tnbcc Yannoukakos, D Fletcher, O Johnson, N dos Santos Silva, I Peto, J Marme, F Burwinkel, B Guenel, P Truong, T Sanchez, M Mulot, C Bojesen, S E Nordestgaard, B G Flyer, H Brenner, H Dieffenbach, A K Arndt, V Stegmaier, C Mannermaa, A Kataja, V Kosma, V -M Hartikainen, J M Lambrechts, D Yesilyurt, B T Floris, G Leunen, K Chang-Claude, J Rudolph, A Seibold, P Flesch-Janys, D Wang, X Olson, J E Vachon, C Purrington, K Giles, G G Severi, G Baglietto, L Haiman, C A Henderson, B E Schumacher, F Marchand, L Le Simard, J Dumont, M Goldberg, M S Labreche, F Winqvist, R Pylkas, K Jukkola-Vuorinen, A Grip, M Devilee, P Tollenaar, R A E M Seynaeve, C Garcia-Closas, M Chanock, S J Lissowska, J Figueroa, J D Czene, K Eriksson, M Humphreys, K Darabi, H Hooning, M J Kriege, M Collee, J M Tilanus-Linthorst, M Li, J Jakubowska, A Lubinski, J Jaworska-Bieniek, K Durda, K Nevanlinna, H Muranen, T A Aittomaki, K Blomqvist, C Bogdanova, N Dork, T Hall, P Chenevix-Trench, G Easton, D F Pharroah, P D P Arias-Perez, J I Zamora, P Benitez, J Milne, R L 1U19 CA148065/CA/NCI NIH HHS/United States 1U19 CA148112/CA/NCI NIH HHS/United States C1287/A10118/Cancer Research UK/United Kingdom C1287/A10710/Cancer Research UK/United Kingdom C1287/A12014/Cancer Research UK/United Kingdom C490/A10124/Cancer Research UK/United Kingdom CA098758/CA/NCI NIH HHS/United States CA128978/CA/NCI NIH HHS/United States CA132839/CA/NCI NIH HHS/United States CA54281/CA/NCI NIH HHS/United States CA63464/CA/NCI NIH HHS/United States CRN-87521/Canadian Institutes of Health Research/Canada P30 CA68485/CA/NCI NIH HHS/United States P50 CA116201/CA/NCI NIH HHS/United States R01 CA092447/CA/NCI NIH HHS/United States R01 CA122340/CA/NCI NIH HHS/United States R01 CA128978/CA/NCI NIH HHS/United States R01CA100374/CA/NCI NIH HHS/United States R01CA148667/CA/NCI NIH HHS/United States R01CA64277/CA/NCI NIH HHS/United States R37CA70867/CA/NCI NIH HHS/United States U19 CA148537/CA/NCI NIH HHS/United States UM1 CA164920/CA/NCI NIH HHS/United States Multicenter Study Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. England British journal of cancer Br J Cancer. 2014 Feb 18;110(4):1088-100. doi: 10.1038/bjc.2013.769.

PY - 2014

Y1 - 2014

N2 - Background:Breast cancer is one of the most common malignancies in women. Genome-wide association studies have identified FGFR2 as a breast cancer susceptibility gene. Common variation in other fibroblast growth factor (FGF) receptors might also modify risk. We tested this hypothesis by studying genotyped single-nucleotide polymorphisms (SNPs) and imputed SNPs in FGFR1, FGFR3, FGFR4 and FGFRL1 in the Breast Cancer Association Consortium.Methods:Data were combined from 49 studies, including 53 835 cases and 50 156 controls, of which 89 050 (46 450 cases and 42 600 controls) were of European ancestry, 12 893 (6269 cases and 6624 controls) of Asian and 2048 (1116 cases and 932 controls) of African ancestry. Associations with risk of breast cancer, overall and by disease sub-type, were assessed using unconditional logistic regression.Results:Little evidence of association with breast cancer risk was observed for SNPs in the FGF receptor genes. The strongest evidence in European women was for rs743682 in FGFR3; the estimated per-allele odds ratio was 1.05 (95% confidence interval=1.02-1.09, P=0.0020), which is substantially lower than that observed for SNPs in FGFR2.Conclusion:Our results suggest that common variants in the other FGF receptors are not associated with risk of breast cancer to the degree observed for FGFR2.

AB - Background:Breast cancer is one of the most common malignancies in women. Genome-wide association studies have identified FGFR2 as a breast cancer susceptibility gene. Common variation in other fibroblast growth factor (FGF) receptors might also modify risk. We tested this hypothesis by studying genotyped single-nucleotide polymorphisms (SNPs) and imputed SNPs in FGFR1, FGFR3, FGFR4 and FGFRL1 in the Breast Cancer Association Consortium.Methods:Data were combined from 49 studies, including 53 835 cases and 50 156 controls, of which 89 050 (46 450 cases and 42 600 controls) were of European ancestry, 12 893 (6269 cases and 6624 controls) of Asian and 2048 (1116 cases and 932 controls) of African ancestry. Associations with risk of breast cancer, overall and by disease sub-type, were assessed using unconditional logistic regression.Results:Little evidence of association with breast cancer risk was observed for SNPs in the FGF receptor genes. The strongest evidence in European women was for rs743682 in FGFR3; the estimated per-allele odds ratio was 1.05 (95% confidence interval=1.02-1.09, P=0.0020), which is substantially lower than that observed for SNPs in FGFR2.Conclusion:Our results suggest that common variants in the other FGF receptors are not associated with risk of breast cancer to the degree observed for FGFR2.

KW - Breast Neoplasms/ genetics

KW - Case-Control Studies

KW - Female

KW - Genetic Predisposition to Disease

KW - Genetic Variation

KW - Genome-Wide Association Study

KW - Genotype

KW - Humans

KW - Polymorphism, Single Nucleotide/genetics

KW - Receptor, Fibroblast Growth Factor, Type 1/genetics

KW - Receptor, Fibroblast Growth Factor, Type 2/ genetics

KW - Receptor, Fibroblast Growth Factor, Type 3/genetics

KW - Receptor, Fibroblast Growth Factor, Type 4/genetics

KW - Receptor, Fibroblast Growth Factor, Type 5/genetics

U2 - 10.1038/bjc.2013.769

DO - 10.1038/bjc.2013.769

M3 - Article

SN - 1532-1827

VL - 110

SP - 1088

EP - 1100

JO - Br J Cancer

JF - Br J Cancer

IS - 4

ER -

FGF receptor genes and breast cancer susceptibility: results from the Breast Cancer Association Consortium

Abstract

Keywords

UN SDGs

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