Fibrillin degradation by matrix metalloproteinases: Identification of amino- and carboxy-terminal cleavage sites

V. John Hindson, Jane L. Ashworth, Matthew J. Rock, Sharon Cunliffe, C. Adrian Shuttleworth, Cay M. Kielty

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Fibrillin molecules form the structural framework of elastic fibrillin-rich microfibrils of the extracellular matrix. We have investigated the proteolysis of recombinant fibrillin molecules by five matrix metalloproteinases. Cleavage sites were defined at the carboxy-terminal end of the fibrillin-1 proline-rich region and the corresponding fibrillin-2 glycine-rich region (exon 10), and within exon 49 towards the carboxy-terminus of fibrillin-1. Cleavage at these sites is predicted to disrupt the structure and function of the fibrillin-rich microfibrils. Copyright (C) 1999 Federation of European Biochemical Societies.
    Original languageEnglish
    Pages (from-to)195-198
    Number of pages3
    JournalFEBS Letters
    Volume452
    Issue number3
    DOIs
    Publication statusPublished - 11 Jun 1999

    Keywords

    • Elastic microfibril
    • Fibrillin
    • Matrix metalloproteinase

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