First-in-Human Technique Translation of Oxygen-Enhanced MRI to an MR Linac System in Patients with Head and Neck Cancer

Michael J Dubec; David L Buckley; Michael Berks; Abigael Clough; John Gaffney; Anubhav Datta; Damien J McHugh; Nuria Porta; Ross A Little; Susan Cheung; Christina Hague; Cynthia L Eccles; Peter J Hoskin; Robert G Bristow; Julian C Matthews; Marcel van Herk; Ananya Choudhury; Geoff Jm Parker; Andrew McPartlin; James Pb O'Connor

doi:10.1016/j.radonc.2023.109592

First-in-Human Technique Translation of Oxygen-Enhanced MRI to an MR Linac System in Patients with Head and Neck Cancer

Michael J Dubec, David L Buckley, Michael Berks, Abigael Clough, John Gaffney, Anubhav Datta, Damien J McHugh, Nuria Porta, Ross A Little, Susan Cheung, Christina Hague, Cynthia L Eccles, Peter J Hoskin, Robert G Bristow, Julian C Matthews, Marcel van Herk, Ananya Choudhury, Geoff Jm Parker, Andrew McPartlin, James Pb O'Connor

Research output: Contribution to journal › Article › peer-review

Abstract

BACKGROUND AND PURPOSE: Tumour hypoxia is prognostic in head and neck cancer (HNC), associated with poor loco-regional control, poor survival and treatment resistance. The advent of hybrid MRI - radiotherapy linear accelerator or 'MR Linac' systems - could permit imaging for treatment adaptation based on hypoxic status. We sought to develop oxygen-enhanced MRI (OE-MRI) in HNC and translate the technique onto an MR Linac system.

MATERIALS AND METHODS: MRI sequences were developed in phantoms and 15 healthy participants. Next, 14 HNC patients (with 21 primary or local nodal tumours) were evaluated. Baseline tissue longitudinal relaxation time (T 1) was measured alongside the change in 1/T 1 (termed ΔR 1) between air and oxygen gas breathing phases. We compared results from 1.5 T diagnostic MR and MR Linac systems.

RESULTS: Baseline T 1 had excellent repeatability in phantoms, healthy participants and patients on both systems. Cohort nasal concha oxygen-induced ΔR 1 significantly increased (p<0.0001) in healthy participants demonstrating OE-MRI feasibility. ΔR 1 repeatability coefficients (RC) were 0.023-0.040 s -1 across both MR systems. The tumour ΔR 1 RC was 0.013 s -1 and the within-subject coefficient of variation (wCV) was 25% on the diagnostic MR. Tumour ΔR 1 RC was 0.020 s -1 and wCV was 33% on the MR Linac. ΔR 1 magnitude and time-course trends were similar on both systems.

CONCLUSION: We demonstrate first-in-human translation of volumetric, dynamic OE-MRI onto an MR Linac system, yielding repeatable hypoxia biomarkers. Data were equivalent on the diagnostic MR and MR Linac systems. OE-MRI has potential to guide future clinical trials of biology guided adaptive radiotherapy.

Original language	English
Pages (from-to)	109592
Journal	Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
Early online date	2 Mar 2023
DOIs	https://doi.org/10.1016/j.radonc.2023.109592
Publication status	Published - 2 Mar 2023

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10.1016/j.radonc.2023.109592

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Dubec, M. J., Buckley, D. L., Berks, M., Clough, A., Gaffney, J., Datta, A., McHugh, D. J., Porta, N., Little, R. A., Cheung, S., Hague, C., Eccles, C. L., Hoskin, P. J., Bristow, R. G., Matthews, J. C., van Herk, M., Choudhury, A., Jm Parker, G., McPartlin, A., & Pb O'Connor, J. (2023). First-in-Human Technique Translation of Oxygen-Enhanced MRI to an MR Linac System in Patients with Head and Neck Cancer. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 109592. https://doi.org/10.1016/j.radonc.2023.109592

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title = "First-in-Human Technique Translation of Oxygen-Enhanced MRI to an MR Linac System in Patients with Head and Neck Cancer",

abstract = "BACKGROUND AND PURPOSE: Tumour hypoxia is prognostic in head and neck cancer (HNC), associated with poor loco-regional control, poor survival and treatment resistance. The advent of hybrid MRI - radiotherapy linear accelerator or 'MR Linac' systems - could permit imaging for treatment adaptation based on hypoxic status. We sought to develop oxygen-enhanced MRI (OE-MRI) in HNC and translate the technique onto an MR Linac system.MATERIALS AND METHODS: MRI sequences were developed in phantoms and 15 healthy participants. Next, 14 HNC patients (with 21 primary or local nodal tumours) were evaluated. Baseline tissue longitudinal relaxation time (T 1) was measured alongside the change in 1/T 1 (termed ΔR 1) between air and oxygen gas breathing phases. We compared results from 1.5 T diagnostic MR and MR Linac systems. RESULTS: Baseline T 1 had excellent repeatability in phantoms, healthy participants and patients on both systems. Cohort nasal concha oxygen-induced ΔR 1 significantly increased (p<0.0001) in healthy participants demonstrating OE-MRI feasibility. ΔR 1 repeatability coefficients (RC) were 0.023-0.040 s -1 across both MR systems. The tumour ΔR 1 RC was 0.013 s -1 and the within-subject coefficient of variation (wCV) was 25% on the diagnostic MR. Tumour ΔR 1 RC was 0.020 s -1 and wCV was 33% on the MR Linac. ΔR 1 magnitude and time-course trends were similar on both systems. CONCLUSION: We demonstrate first-in-human translation of volumetric, dynamic OE-MRI onto an MR Linac system, yielding repeatable hypoxia biomarkers. Data were equivalent on the diagnostic MR and MR Linac systems. OE-MRI has potential to guide future clinical trials of biology guided adaptive radiotherapy.",

author = "Dubec, {Michael J} and Buckley, {David L} and Michael Berks and Abigael Clough and John Gaffney and Anubhav Datta and McHugh, {Damien J} and Nuria Porta and Little, {Ross A} and Susan Cheung and Christina Hague and Eccles, {Cynthia L} and Hoskin, {Peter J} and Bristow, {Robert G} and Matthews, {Julian C} and {van Herk}, Marcel and Ananya Choudhury and {Jm Parker}, Geoff and Andrew McPartlin and {Pb O'Connor}, James",

note = "Copyright {\textcopyright} 2023. Published by Elsevier B.V.",

year = "2023",

month = mar,

day = "2",

doi = "10.1016/j.radonc.2023.109592",

language = "English",

pages = "109592",

journal = "Radiotherapy & Oncology",

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Dubec, MJ, Buckley, DL, Berks, M, Clough, A, Gaffney, J, Datta, A , McHugh, DJ, Porta, N, Little, RA, Cheung, S, Hague, C, Eccles, CL , Hoskin, PJ, Bristow, RG, Matthews, JC , van Herk, M , Choudhury, A , Jm Parker, G, McPartlin, A & Pb O'Connor, J 2023, 'First-in-Human Technique Translation of Oxygen-Enhanced MRI to an MR Linac System in Patients with Head and Neck Cancer', Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, pp. 109592. https://doi.org/10.1016/j.radonc.2023.109592

First-in-Human Technique Translation of Oxygen-Enhanced MRI to an MR Linac System in Patients with Head and Neck Cancer. / Dubec, Michael J; Buckley, David L; Berks, Michael et al.

In: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 02.03.2023, p. 109592.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - First-in-Human Technique Translation of Oxygen-Enhanced MRI to an MR Linac System in Patients with Head and Neck Cancer

AU - Dubec, Michael J

AU - Buckley, David L

AU - Berks, Michael

AU - Clough, Abigael

AU - Gaffney, John

AU - Datta, Anubhav

AU - McHugh, Damien J

AU - Porta, Nuria

AU - Little, Ross A

AU - Cheung, Susan

AU - Hague, Christina

AU - Eccles, Cynthia L

AU - Hoskin, Peter J

AU - Bristow, Robert G

AU - Matthews, Julian C

AU - van Herk, Marcel

AU - Choudhury, Ananya

AU - Jm Parker, Geoff

AU - McPartlin, Andrew

AU - Pb O'Connor, James

PY - 2023/3/2

Y1 - 2023/3/2

N2 - BACKGROUND AND PURPOSE: Tumour hypoxia is prognostic in head and neck cancer (HNC), associated with poor loco-regional control, poor survival and treatment resistance. The advent of hybrid MRI - radiotherapy linear accelerator or 'MR Linac' systems - could permit imaging for treatment adaptation based on hypoxic status. We sought to develop oxygen-enhanced MRI (OE-MRI) in HNC and translate the technique onto an MR Linac system.MATERIALS AND METHODS: MRI sequences were developed in phantoms and 15 healthy participants. Next, 14 HNC patients (with 21 primary or local nodal tumours) were evaluated. Baseline tissue longitudinal relaxation time (T 1) was measured alongside the change in 1/T 1 (termed ΔR 1) between air and oxygen gas breathing phases. We compared results from 1.5 T diagnostic MR and MR Linac systems. RESULTS: Baseline T 1 had excellent repeatability in phantoms, healthy participants and patients on both systems. Cohort nasal concha oxygen-induced ΔR 1 significantly increased (p<0.0001) in healthy participants demonstrating OE-MRI feasibility. ΔR 1 repeatability coefficients (RC) were 0.023-0.040 s -1 across both MR systems. The tumour ΔR 1 RC was 0.013 s -1 and the within-subject coefficient of variation (wCV) was 25% on the diagnostic MR. Tumour ΔR 1 RC was 0.020 s -1 and wCV was 33% on the MR Linac. ΔR 1 magnitude and time-course trends were similar on both systems. CONCLUSION: We demonstrate first-in-human translation of volumetric, dynamic OE-MRI onto an MR Linac system, yielding repeatable hypoxia biomarkers. Data were equivalent on the diagnostic MR and MR Linac systems. OE-MRI has potential to guide future clinical trials of biology guided adaptive radiotherapy.

AB - BACKGROUND AND PURPOSE: Tumour hypoxia is prognostic in head and neck cancer (HNC), associated with poor loco-regional control, poor survival and treatment resistance. The advent of hybrid MRI - radiotherapy linear accelerator or 'MR Linac' systems - could permit imaging for treatment adaptation based on hypoxic status. We sought to develop oxygen-enhanced MRI (OE-MRI) in HNC and translate the technique onto an MR Linac system.MATERIALS AND METHODS: MRI sequences were developed in phantoms and 15 healthy participants. Next, 14 HNC patients (with 21 primary or local nodal tumours) were evaluated. Baseline tissue longitudinal relaxation time (T 1) was measured alongside the change in 1/T 1 (termed ΔR 1) between air and oxygen gas breathing phases. We compared results from 1.5 T diagnostic MR and MR Linac systems. RESULTS: Baseline T 1 had excellent repeatability in phantoms, healthy participants and patients on both systems. Cohort nasal concha oxygen-induced ΔR 1 significantly increased (p<0.0001) in healthy participants demonstrating OE-MRI feasibility. ΔR 1 repeatability coefficients (RC) were 0.023-0.040 s -1 across both MR systems. The tumour ΔR 1 RC was 0.013 s -1 and the within-subject coefficient of variation (wCV) was 25% on the diagnostic MR. Tumour ΔR 1 RC was 0.020 s -1 and wCV was 33% on the MR Linac. ΔR 1 magnitude and time-course trends were similar on both systems. CONCLUSION: We demonstrate first-in-human translation of volumetric, dynamic OE-MRI onto an MR Linac system, yielding repeatable hypoxia biomarkers. Data were equivalent on the diagnostic MR and MR Linac systems. OE-MRI has potential to guide future clinical trials of biology guided adaptive radiotherapy.

U2 - 10.1016/j.radonc.2023.109592

DO - 10.1016/j.radonc.2023.109592

M3 - Article

C2 - 36870608

SP - 109592

JO - Radiotherapy & Oncology

JF - Radiotherapy & Oncology

SN - 0167-8140

ER -

First-in-Human Technique Translation of Oxygen-Enhanced MRI to an MR Linac System in Patients with Head and Neck Cancer

Abstract

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