First results on cell irradiation with laser-driven protons on the TARANIS system

S Kar; D Doria; KF Kakolee; R Prasad; S Litt; H Ahmed; G Nersisyan; C Lewis; M Zepf; M Borghesi; G Schettino; KM Prise; F Fiorini; D Kirby; S Green; JCG Jeynes; MJ Merchant; KJ Kirkby

doi:10.1063/1.4816612

First results on cell irradiation with laser-driven protons on the TARANIS system

S Kar, D Doria, KF Kakolee, R Prasad, S Litt, H Ahmed, G Nersisyan, C Lewis, M Zepf, M Borghesi, G Schettino, KM Prise, F Fiorini, D Kirby, S Green, JCG Jeynes, MJ Merchant, KJ Kirkby

Research output: Contribution to journal › Article › peer-review

Abstract

The ultra short duration of laser-driven multi-MeV ion bursts offers the possibility of radiobiological studies at extremely high dose rates. Employing the TARANIS Terawatt laser at Queen's University, the effect of proton irradiation at MeV-range energies on live cells has been investigated at dose rates exceeding 10 Gy/s as a single exposure. A clonogenic assay showed consistent lethal effects on V-79 live, cells, which, even at these dose rates, appear to be in line with previously published results employing conventional sources. A Relative Biological Effectiveness (RBE) of 1.4??0.2 at 10% survival is estimated from a comparison with a 225 kVp X-ray source. ?? 2013 AIP Publishing LLC.

Original language	English
Pages (from-to)	87-89
Number of pages	3
Journal	AIP Conference Proceedings
Volume	1546
DOIs	https://doi.org/10.1063/1.4816612
Publication status	Published - 2013

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Kar, S., Doria, D., Kakolee, KF., Prasad, R., Litt, S., Ahmed, H., Nersisyan, G., Lewis, C., Zepf, M., Borghesi, M., Schettino, G., Prise, KM., Fiorini, F., Kirby, D., Green, S., Jeynes, JCG., Merchant, MJ., & Kirkby, KJ. (2013). First results on cell irradiation with laser-driven protons on the TARANIS system. AIP Conference Proceedings, 1546, 87-89. https://doi.org/10.1063/1.4816612

@article{fccfcafdf8674497b341fbbccd1225d4,

title = "First results on cell irradiation with laser-driven protons on the TARANIS system",

abstract = "The ultra short duration of laser-driven multi-MeV ion bursts offers the possibility of radiobiological studies at extremely high dose rates. Employing the TARANIS Terawatt laser at Queen's University, the effect of proton irradiation at MeV-range energies on live cells has been investigated at dose rates exceeding 10 Gy/s as a single exposure. A clonogenic assay showed consistent lethal effects on V-79 live, cells, which, even at these dose rates, appear to be in line with previously published results employing conventional sources. A Relative Biological Effectiveness (RBE) of 1.4??0.2 at 10% survival is estimated from a comparison with a 225 kVp X-ray source. ?? 2013 AIP Publishing LLC.",

author = "S Kar and D Doria and KF Kakolee and R Prasad and S Litt and H Ahmed and G Nersisyan and C Lewis and M Zepf and M Borghesi and G Schettino and KM Prise and F Fiorini and D Kirby and S Green and JCG Jeynes and MJ Merchant and KJ Kirkby",

year = "2013",

doi = "10.1063/1.4816612",

language = "English",

volume = "1546",

pages = "87--89",

journal = "AIP Conference Proceedings",

issn = "1551-7616",

publisher = "American Institute of Physics",

}

Kar, S, Doria, D, Kakolee, KF, Prasad, R, Litt, S, Ahmed, H, Nersisyan, G, Lewis, C, Zepf, M, Borghesi, M, Schettino, G, Prise, KM, Fiorini, F, Kirby, D, Green, S, Jeynes, JCG, Merchant, MJ & Kirkby, KJ 2013, 'First results on cell irradiation with laser-driven protons on the TARANIS system', AIP Conference Proceedings, vol. 1546, pp. 87-89. https://doi.org/10.1063/1.4816612

TY - JOUR

T1 - First results on cell irradiation with laser-driven protons on the TARANIS system

AU - Kar, S

AU - Doria, D

AU - Kakolee, KF

AU - Prasad, R

AU - Litt, S

AU - Ahmed, H

AU - Nersisyan, G

AU - Lewis, C

AU - Zepf, M

AU - Borghesi, M

AU - Schettino, G

AU - Prise, KM

AU - Fiorini, F

AU - Kirby, D

AU - Green, S

AU - Jeynes, JCG

AU - Merchant, MJ

AU - Kirkby, KJ

PY - 2013

Y1 - 2013

N2 - The ultra short duration of laser-driven multi-MeV ion bursts offers the possibility of radiobiological studies at extremely high dose rates. Employing the TARANIS Terawatt laser at Queen's University, the effect of proton irradiation at MeV-range energies on live cells has been investigated at dose rates exceeding 10 Gy/s as a single exposure. A clonogenic assay showed consistent lethal effects on V-79 live, cells, which, even at these dose rates, appear to be in line with previously published results employing conventional sources. A Relative Biological Effectiveness (RBE) of 1.4??0.2 at 10% survival is estimated from a comparison with a 225 kVp X-ray source. ?? 2013 AIP Publishing LLC.

AB - The ultra short duration of laser-driven multi-MeV ion bursts offers the possibility of radiobiological studies at extremely high dose rates. Employing the TARANIS Terawatt laser at Queen's University, the effect of proton irradiation at MeV-range energies on live cells has been investigated at dose rates exceeding 10 Gy/s as a single exposure. A clonogenic assay showed consistent lethal effects on V-79 live, cells, which, even at these dose rates, appear to be in line with previously published results employing conventional sources. A Relative Biological Effectiveness (RBE) of 1.4??0.2 at 10% survival is estimated from a comparison with a 225 kVp X-ray source. ?? 2013 AIP Publishing LLC.

U2 - 10.1063/1.4816612

DO - 10.1063/1.4816612

M3 - Article

SN - 1551-7616

VL - 1546

SP - 87

EP - 89

JO - AIP Conference Proceedings

JF - AIP Conference Proceedings

ER -

First results on cell irradiation with laser-driven protons on the TARANIS system

Abstract

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