Flecainide and Antiarrhythmic Effects in a Mouse Model of Catecholaminergic Polymorphic Ventricular Tachycardia

Luigi Venetucci; Nian Liu; Carlo Napolitano; Luigi A. Venetucci; Silvia G. Priori

doi:10.1016/j.tcm.2012.06.008

Flecainide and Antiarrhythmic Effects in a Mouse Model of Catecholaminergic Polymorphic Ventricular Tachycardia

Luigi Venetucci, Nian Liu, Carlo Napolitano, Luigi A. Venetucci, Silvia G. Priori

Research output: Contribution to journal › Article › peer-review

Abstract

Recent studies have shown that flecainide may be an effective therapy to prevent life-threatening arrhythmias in patients with catecholaminergic polymorphic ventricular tachycardia. Several hypotheses have been advanced to explain the antiarrhythmic mechanism of flecainide, including Na+ channel blockade and a direct inhibitory action on the ryanodine receptor. In this article, we review the current literature on the topic and summarize the elements of the existing debate. © 2012 Elsevier Inc.

Original language	English
Pages (from-to)	35-39
Number of pages	4
Journal	Trends in Cardiovascular Medicine
Volume	22
Issue number	2
DOIs	https://doi.org/10.1016/j.tcm.2012.06.008
Publication status	Published - Feb 2012

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10.1016/j.tcm.2012.06.008

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title = "Flecainide and Antiarrhythmic Effects in a Mouse Model of Catecholaminergic Polymorphic Ventricular Tachycardia",

abstract = "Recent studies have shown that flecainide may be an effective therapy to prevent life-threatening arrhythmias in patients with catecholaminergic polymorphic ventricular tachycardia. Several hypotheses have been advanced to explain the antiarrhythmic mechanism of flecainide, including Na+ channel blockade and a direct inhibitory action on the ryanodine receptor. In this article, we review the current literature on the topic and summarize the elements of the existing debate. {\textcopyright} 2012 Elsevier Inc.",

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AU - Liu, Nian

AU - Napolitano, Carlo

AU - Venetucci, Luigi A.

AU - Priori, Silvia G.

PY - 2012/2

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N2 - Recent studies have shown that flecainide may be an effective therapy to prevent life-threatening arrhythmias in patients with catecholaminergic polymorphic ventricular tachycardia. Several hypotheses have been advanced to explain the antiarrhythmic mechanism of flecainide, including Na+ channel blockade and a direct inhibitory action on the ryanodine receptor. In this article, we review the current literature on the topic and summarize the elements of the existing debate. © 2012 Elsevier Inc.

AB - Recent studies have shown that flecainide may be an effective therapy to prevent life-threatening arrhythmias in patients with catecholaminergic polymorphic ventricular tachycardia. Several hypotheses have been advanced to explain the antiarrhythmic mechanism of flecainide, including Na+ channel blockade and a direct inhibitory action on the ryanodine receptor. In this article, we review the current literature on the topic and summarize the elements of the existing debate. © 2012 Elsevier Inc.

U2 - 10.1016/j.tcm.2012.06.008

DO - 10.1016/j.tcm.2012.06.008

M3 - Article

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JO - Trends in Cardiovascular Medicine

JF - Trends in Cardiovascular Medicine

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Flecainide and Antiarrhythmic Effects in a Mouse Model of Catecholaminergic Polymorphic Ventricular Tachycardia

Abstract

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