Fluconazole loading dose pharmacokinetics and safety in infants

Lauren Piper; P. Brian Smith; Christoph P. Hornik; Ira M. Cheifetz; Jeffrey S. Barrett; Ganesh Moorthy; William W. Hope; Kelly C. Wade; Michael Cohen-Wolkowiez; Daniel K. Benjamin

doi:10.1097/INF.0b013e318202cbb3

Fluconazole loading dose pharmacokinetics and safety in infants

Lauren Piper, P. Brian Smith, Christoph P. Hornik, Ira M. Cheifetz, Jeffrey S. Barrett, Ganesh Moorthy, William W. Hope, Kelly C. Wade, Michael Cohen-Wolkowiez, Daniel K. Benjamin

Research output: Contribution to journal › Article › peer-review

Abstract

BACKGROUND: Invasive candidiasis is a leading cause of morbidity and mortality in critically ill infants. Prompt administration of fluconazole and achievement of the therapeutic target (area under the curve 0 to 24 hours >400 mg*h/L) improve outcomes in candidemic patients. A loading dose of fluconazole is advised for older patients but has not been evaluated in infants. We sought to determine the pharmacokinetics and safety of a fluconazole loading dose in infants at risk for invasive fungal infection. METHODS: We enrolled 10 hospitalized infants 8 μg/mL. No adverse events were thought to be related to fluconazole therapy. CONCLUSIONS: A loading dose of fluconazole (25 mg/kg) was safe in this small cohort of young infants and achieved the therapeutic target more rapidly than traditional dosing. Copyright © 2011 by Lippincott Williams &Wilkins.

Original language	English
Pages (from-to)	375-378
Number of pages	3
Journal	Pediatric Infectious Disease Journal
Volume	30
Issue number	5
DOIs	https://doi.org/10.1097/INF.0b013e318202cbb3
Publication status	Published - May 2011

Keywords

candidiasis
fluconazole
infant
neonate
pharmacology

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10.1097/INF.0b013e318202cbb3

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@article{4d1b051ccdfc40a297ad0c824460b33c,

title = "Fluconazole loading dose pharmacokinetics and safety in infants",

abstract = "BACKGROUND: Invasive candidiasis is a leading cause of morbidity and mortality in critically ill infants. Prompt administration of fluconazole and achievement of the therapeutic target (area under the curve 0 to 24 hours >400 mg*h/L) improve outcomes in candidemic patients. A loading dose of fluconazole is advised for older patients but has not been evaluated in infants. We sought to determine the pharmacokinetics and safety of a fluconazole loading dose in infants at risk for invasive fungal infection. METHODS: We enrolled 10 hospitalized infants 8 μg/mL. No adverse events were thought to be related to fluconazole therapy. CONCLUSIONS: A loading dose of fluconazole (25 mg/kg) was safe in this small cohort of young infants and achieved the therapeutic target more rapidly than traditional dosing. Copyright {\textcopyright} 2011 by Lippincott Williams &Wilkins.",

keywords = "candidiasis, fluconazole, infant, neonate, pharmacology",

author = "Lauren Piper and Smith, {P. Brian} and Hornik, {Christoph P.} and Cheifetz, {Ira M.} and Barrett, {Jeffrey S.} and Ganesh Moorthy and Hope, {William W.} and Wade, {Kelly C.} and Michael Cohen-Wolkowiez and Benjamin, {Daniel K.}",

year = "2011",

month = may,

doi = "10.1097/INF.0b013e318202cbb3",

language = "English",

volume = "30",

pages = "375--378",

journal = "Pediatric Infectious Disease Journal",

issn = "0891-3668",

publisher = "Lippincott Williams & Wilkins",

number = "5",

}

TY - JOUR

T1 - Fluconazole loading dose pharmacokinetics and safety in infants

AU - Piper, Lauren

AU - Smith, P. Brian

AU - Hornik, Christoph P.

AU - Cheifetz, Ira M.

AU - Barrett, Jeffrey S.

AU - Moorthy, Ganesh

AU - Hope, William W.

AU - Wade, Kelly C.

AU - Cohen-Wolkowiez, Michael

AU - Benjamin, Daniel K.

PY - 2011/5

Y1 - 2011/5

N2 - BACKGROUND: Invasive candidiasis is a leading cause of morbidity and mortality in critically ill infants. Prompt administration of fluconazole and achievement of the therapeutic target (area under the curve 0 to 24 hours >400 mg*h/L) improve outcomes in candidemic patients. A loading dose of fluconazole is advised for older patients but has not been evaluated in infants. We sought to determine the pharmacokinetics and safety of a fluconazole loading dose in infants at risk for invasive fungal infection. METHODS: We enrolled 10 hospitalized infants 8 μg/mL. No adverse events were thought to be related to fluconazole therapy. CONCLUSIONS: A loading dose of fluconazole (25 mg/kg) was safe in this small cohort of young infants and achieved the therapeutic target more rapidly than traditional dosing. Copyright © 2011 by Lippincott Williams &Wilkins.

AB - BACKGROUND: Invasive candidiasis is a leading cause of morbidity and mortality in critically ill infants. Prompt administration of fluconazole and achievement of the therapeutic target (area under the curve 0 to 24 hours >400 mg*h/L) improve outcomes in candidemic patients. A loading dose of fluconazole is advised for older patients but has not been evaluated in infants. We sought to determine the pharmacokinetics and safety of a fluconazole loading dose in infants at risk for invasive fungal infection. METHODS: We enrolled 10 hospitalized infants 8 μg/mL. No adverse events were thought to be related to fluconazole therapy. CONCLUSIONS: A loading dose of fluconazole (25 mg/kg) was safe in this small cohort of young infants and achieved the therapeutic target more rapidly than traditional dosing. Copyright © 2011 by Lippincott Williams &Wilkins.

KW - candidiasis

KW - fluconazole

KW - infant

KW - neonate

KW - pharmacology

U2 - 10.1097/INF.0b013e318202cbb3

DO - 10.1097/INF.0b013e318202cbb3

M3 - Article

SN - 0891-3668

VL - 30

SP - 375

EP - 378

JO - Pediatric Infectious Disease Journal

JF - Pediatric Infectious Disease Journal

IS - 5

ER -

Fluconazole loading dose pharmacokinetics and safety in infants

Abstract

Keywords

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