Fluorescence-lifetime imaging of DNA-dye interactions within continuous-flow microfluidic systems

Richard K P Benninger; Oliver Hofmann; Björn Önfelt; Ian Munro; Chris Dunsby; Daniel M. Davis; Mark A A Neil; Paul M W French; Andrew J. De Mello

doi:10.1002/anie.200604112

Fluorescence-lifetime imaging of DNA-dye interactions within continuous-flow microfluidic systems

Richard K P Benninger, Oliver Hofmann, Björn Önfelt, Ian Munro, Chris Dunsby, Daniel M. Davis, Mark A A Neil, Paul M W French, Andrew J. De Mello

Research output: Contribution to journal › Article › peer-review

Abstract

(Figure Presented) Light across the channel: The utility of time-resolved fluorescence imaging as a detection modality for microfluidic systems has been extended by a study of DNA-dye binding interactions. The combination of time-resolved fluorescence imaging and continuous-flow microfluidics provides a powerful route to the resolution and quantification of multistate biological systems with precise spatial and temporal reaction control. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

Original language	English
Pages (from-to)	2228-2231
Number of pages	3
Journal	Angewandte Chemie - International Edition
Volume	46
Issue number	13
DOIs	https://doi.org/10.1002/anie.200604112
Publication status	Published - 2007

Keywords

Fluorescence
Imaging
Intercalation
Microfluidics
Microreactors

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10.1002/anie.200604112

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title = "Fluorescence-lifetime imaging of DNA-dye interactions within continuous-flow microfluidic systems",

abstract = "(Figure Presented) Light across the channel: The utility of time-resolved fluorescence imaging as a detection modality for microfluidic systems has been extended by a study of DNA-dye binding interactions. The combination of time-resolved fluorescence imaging and continuous-flow microfluidics provides a powerful route to the resolution and quantification of multistate biological systems with precise spatial and temporal reaction control. {\textcopyright} 2007 Wiley-VCH Verlag GmbH & Co. KGaA.",

keywords = "Fluorescence, Imaging, Intercalation, Microfluidics, Microreactors",

author = "Benninger, {Richard K P} and Oliver Hofmann and Bj{\"o}rn {\"O}nfelt and Ian Munro and Chris Dunsby and Davis, {Daniel M.} and Neil, {Mark A A} and French, {Paul M W} and {De Mello}, {Andrew J.}",

year = "2007",

doi = "10.1002/anie.200604112",

language = "English",

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journal = "Angewandte Chemie - International Edition",

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T1 - Fluorescence-lifetime imaging of DNA-dye interactions within continuous-flow microfluidic systems

AU - Benninger, Richard K P

AU - Hofmann, Oliver

AU - Önfelt, Björn

AU - Munro, Ian

AU - Dunsby, Chris

AU - Davis, Daniel M.

AU - Neil, Mark A A

AU - French, Paul M W

AU - De Mello, Andrew J.

PY - 2007

Y1 - 2007

N2 - (Figure Presented) Light across the channel: The utility of time-resolved fluorescence imaging as a detection modality for microfluidic systems has been extended by a study of DNA-dye binding interactions. The combination of time-resolved fluorescence imaging and continuous-flow microfluidics provides a powerful route to the resolution and quantification of multistate biological systems with precise spatial and temporal reaction control. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

AB - (Figure Presented) Light across the channel: The utility of time-resolved fluorescence imaging as a detection modality for microfluidic systems has been extended by a study of DNA-dye binding interactions. The combination of time-resolved fluorescence imaging and continuous-flow microfluidics provides a powerful route to the resolution and quantification of multistate biological systems with precise spatial and temporal reaction control. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

KW - Fluorescence

KW - Imaging

KW - Intercalation

KW - Microfluidics

KW - Microreactors

U2 - 10.1002/anie.200604112

DO - 10.1002/anie.200604112

M3 - Article

C2 - 17436333

SN - 1433-7851

VL - 46

SP - 2228

EP - 2231

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 13

ER -

Fluorescence-lifetime imaging of DNA-dye interactions within continuous-flow microfluidic systems

Abstract

Keywords

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