Fluorescent nanothermometers for intracellular thermal sensing

Daniel Jaque, Blanca del Rosal, Emma Martin Rodriguez, Laura Martinez Maestro, Patricia Haro-Gonzalez, Jose Garcia Sole

    Research output: Contribution to journalReview articlepeer-review


    The importance of high-resolution intracellular thermal sensing and imaging in the field of modern biomedicine has boosted the development of novel nanosized fluorescent systems (fluorescent nanothermometers) as the next generation of probes for intracellular thermal sensing and imaging. This thermal mapping requires fluorescent nanothermometers with good biocompatibility and high thermal sensitivity in order to obtain submicrometric and subdegree spatial and thermal resolutions, respectively. This review describes the different nanosized systems used up to now for intracellular thermal sensing and imaging. We also include the later advances in molecular systems based on fluorescent proteins for thermal mapping. A critical overview of the state of the art and the future perspective is also included.
    Original languageEnglish
    Pages (from-to)1047-1062
    Issue number7
    Publication statusPublished - May 2014


    • cellular temperature
    • fluorescent nanoparticle
    • nanotechnology
    • nanothermometry
    • single cell


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