Fluorodeoxyglucose-positron emission tomography and sentinel lymph node biopsy in staging primary cutaneous melanoma

K Havenga; D C P Cobben; W J G Oyen; S Nienhuijs; H J Hoekstra; T J M Ruers; Th Wobbes

doi:10.1016/S0748-7983(03)00147-1

Fluorodeoxyglucose-positron emission tomography and sentinel lymph node biopsy in staging primary cutaneous melanoma

K Havenga, D C P Cobben, W J G Oyen, S Nienhuijs, H J Hoekstra, T J M Ruers, Th Wobbes

Division of Cancer Sciences (L5)

Radboud University Medical Center

Research output: Contribution to journal › Article › peer-review

Abstract

AIM: We report the value of sentinel lymph node (SLN) biopsy and fluorodeoxyglucose-positron emission tomography (FDG-PET) in relation to SLN biopsy in staging primary cutaneous melanoma.

METHODS: Fifty-five patients with primary cutaneous melanoma >1.0 mm. Breslow thickness and no palpable regional lymph nodes underwent a FDG-PET scan before SLN biopsy.

RESULTS: SLN's were retrieved in 53 patients. Melanoma metastases were found in the SLN of 13 patients. FDG-PET detected the lymph node metastases in two of the 13 patients with SLN metastases. In five patients FDG accumulation was recorded in a regional lymph node basin, while no tumour positive SLN was found. In eight patients FDG-PET showed increased activity at a site of possible distant metastasis. Metastatic disease was confirmed in one patient. No explanation for the positive FDG-PET result could be found in five cases.

CONCLUSION: FDG-PET should not be considered in this group. SLN biopsy reveals regional metastases that are too small to be detected by FDG-PET. The prevalence of distant metastases is too small to justify routine use of FDG-PET.

Original language	English
Pages (from-to)	662-4
Number of pages	3
Journal	European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
Volume	29
Issue number	8
DOIs	https://doi.org/10.1016/S0748-7983(03)00147-1
Publication status	Published - Oct 2003

Keywords

Adolescent
Adult
Aged
Female
Fluorodeoxyglucose F18
Humans
Lymphatic Metastasis
Male
Melanoma
Middle Aged
Neoplasm Staging
Predictive Value of Tests
Radiopharmaceuticals
Sentinel Lymph Node Biopsy
Skin Neoplasms
Tomography, Emission-Computed
Journal Article

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S0748-7983(03)00147-1

Cite this

Havenga, K., Cobben, D. C. P., Oyen, W. J. G., Nienhuijs, S., Hoekstra, H. J., Ruers, T. J. M., & Wobbes, T. (2003). Fluorodeoxyglucose-positron emission tomography and sentinel lymph node biopsy in staging primary cutaneous melanoma. European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, 29(8), 662-4. https://doi.org/10.1016/S0748-7983(03)00147-1

@article{d0afef7a4b344434b2d0cc4e375c5594,

title = "Fluorodeoxyglucose-positron emission tomography and sentinel lymph node biopsy in staging primary cutaneous melanoma",

abstract = "AIM: We report the value of sentinel lymph node (SLN) biopsy and fluorodeoxyglucose-positron emission tomography (FDG-PET) in relation to SLN biopsy in staging primary cutaneous melanoma.METHODS: Fifty-five patients with primary cutaneous melanoma >1.0 mm. Breslow thickness and no palpable regional lymph nodes underwent a FDG-PET scan before SLN biopsy.RESULTS: SLN's were retrieved in 53 patients. Melanoma metastases were found in the SLN of 13 patients. FDG-PET detected the lymph node metastases in two of the 13 patients with SLN metastases. In five patients FDG accumulation was recorded in a regional lymph node basin, while no tumour positive SLN was found. In eight patients FDG-PET showed increased activity at a site of possible distant metastasis. Metastatic disease was confirmed in one patient. No explanation for the positive FDG-PET result could be found in five cases.CONCLUSION: FDG-PET should not be considered in this group. SLN biopsy reveals regional metastases that are too small to be detected by FDG-PET. The prevalence of distant metastases is too small to justify routine use of FDG-PET.",

keywords = "Adolescent, Adult, Aged, Female, Fluorodeoxyglucose F18, Humans, Lymphatic Metastasis, Male, Melanoma, Middle Aged, Neoplasm Staging, Predictive Value of Tests, Radiopharmaceuticals, Sentinel Lymph Node Biopsy, Skin Neoplasms, Tomography, Emission-Computed, Journal Article",

author = "K Havenga and Cobben, {D C P} and Oyen, {W J G} and S Nienhuijs and Hoekstra, {H J} and Ruers, {T J M} and Th Wobbes",

year = "2003",

month = oct,

doi = "10.1016/S0748-7983(03)00147-1",

language = "English",

volume = "29",

pages = "662--4",

journal = "European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology",

issn = "0748-7983",

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Havenga, K, Cobben, DCP, Oyen, WJG, Nienhuijs, S, Hoekstra, HJ, Ruers, TJM & Wobbes, T 2003, 'Fluorodeoxyglucose-positron emission tomography and sentinel lymph node biopsy in staging primary cutaneous melanoma', European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, vol. 29, no. 8, pp. 662-4. https://doi.org/10.1016/S0748-7983(03)00147-1

Fluorodeoxyglucose-positron emission tomography and sentinel lymph node biopsy in staging primary cutaneous melanoma. / Havenga, K; Cobben, D C P; Oyen, W J G et al.
In: European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, Vol. 29, No. 8, 10.2003, p. 662-4.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Fluorodeoxyglucose-positron emission tomography and sentinel lymph node biopsy in staging primary cutaneous melanoma

AU - Havenga, K

AU - Cobben, D C P

AU - Oyen, W J G

AU - Nienhuijs, S

AU - Hoekstra, H J

AU - Ruers, T J M

AU - Wobbes, Th

PY - 2003/10

Y1 - 2003/10

N2 - AIM: We report the value of sentinel lymph node (SLN) biopsy and fluorodeoxyglucose-positron emission tomography (FDG-PET) in relation to SLN biopsy in staging primary cutaneous melanoma.METHODS: Fifty-five patients with primary cutaneous melanoma >1.0 mm. Breslow thickness and no palpable regional lymph nodes underwent a FDG-PET scan before SLN biopsy.RESULTS: SLN's were retrieved in 53 patients. Melanoma metastases were found in the SLN of 13 patients. FDG-PET detected the lymph node metastases in two of the 13 patients with SLN metastases. In five patients FDG accumulation was recorded in a regional lymph node basin, while no tumour positive SLN was found. In eight patients FDG-PET showed increased activity at a site of possible distant metastasis. Metastatic disease was confirmed in one patient. No explanation for the positive FDG-PET result could be found in five cases.CONCLUSION: FDG-PET should not be considered in this group. SLN biopsy reveals regional metastases that are too small to be detected by FDG-PET. The prevalence of distant metastases is too small to justify routine use of FDG-PET.

AB - AIM: We report the value of sentinel lymph node (SLN) biopsy and fluorodeoxyglucose-positron emission tomography (FDG-PET) in relation to SLN biopsy in staging primary cutaneous melanoma.METHODS: Fifty-five patients with primary cutaneous melanoma >1.0 mm. Breslow thickness and no palpable regional lymph nodes underwent a FDG-PET scan before SLN biopsy.RESULTS: SLN's were retrieved in 53 patients. Melanoma metastases were found in the SLN of 13 patients. FDG-PET detected the lymph node metastases in two of the 13 patients with SLN metastases. In five patients FDG accumulation was recorded in a regional lymph node basin, while no tumour positive SLN was found. In eight patients FDG-PET showed increased activity at a site of possible distant metastasis. Metastatic disease was confirmed in one patient. No explanation for the positive FDG-PET result could be found in five cases.CONCLUSION: FDG-PET should not be considered in this group. SLN biopsy reveals regional metastases that are too small to be detected by FDG-PET. The prevalence of distant metastases is too small to justify routine use of FDG-PET.

KW - Adolescent

KW - Adult

KW - Aged

KW - Female

KW - Fluorodeoxyglucose F18

KW - Humans

KW - Lymphatic Metastasis

KW - Male

KW - Melanoma

KW - Middle Aged

KW - Neoplasm Staging

KW - Predictive Value of Tests

KW - Radiopharmaceuticals

KW - Sentinel Lymph Node Biopsy

KW - Skin Neoplasms

KW - Tomography, Emission-Computed

KW - Journal Article

U2 - 10.1016/S0748-7983(03)00147-1

DO - 10.1016/S0748-7983(03)00147-1

M3 - Article

C2 - 14511614

SN - 0748-7983

VL - 29

SP - 662

EP - 664

JO - European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

JF - European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

IS - 8

ER -

Havenga K, Cobben DCP, Oyen WJG, Nienhuijs S, Hoekstra HJ, Ruers TJM et al. Fluorodeoxyglucose-positron emission tomography and sentinel lymph node biopsy in staging primary cutaneous melanoma. European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology. 2003 Oct;29(8):662-4. doi: 10.1016/S0748-7983(03)00147-1

Fluorodeoxyglucose-positron emission tomography and sentinel lymph node biopsy in staging primary cutaneous melanoma

Abstract

Keywords

UN SDGs

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