fMRI and MRS measures of neuroplasticity in the pharyngeal motor cortex.

Emilia Michou; Steve Williams; Rishma Vidyasagar; Darragh Downey; Satish Mistry; Richard A E Edden; Shaheen Hamdy

doi:10.1016/j.neuroimage.2015.05.007

fMRI and MRS measures of neuroplasticity in the pharyngeal motor cortex.

Emilia Michou, Steve Williams, Rishma Vidyasagar, Darragh Downey, Satish Mistry, Richard A E Edden, Shaheen Hamdy

Division of Dentistry (L5)

Research output: Contribution to journal › Article › peer-review

Abstract

INTRODUCTION: Paired associative stimulation (PAS), is a novel non-invasive technique where two neural substrates are employed in a temporally coordinated manner in order to modulate cortico-motor excitability within the motor cortex (M1). In swallowing, combined pharyngeal electrical and transcranial-magnetic-stimulation induced beneficial neurophysiological and behavioural effects in healthy subjects and dysphagic stroke patients. Here, we aimed to investigate the whole-brain changes in neural activation during swallowing using functional magnetic resonance imaging (fMRI) following PAS application and in parallel assess associated GABA changes with magnetic resonance spectroscopy (MRS). METHODS: Healthy adults (n=11, 38±9years old) were randomised to receive real and sham PAS to the 'stronger' motor cortex pharyngeal representation, on 2 separate visits. Following PAS, event-related fMRI was performed to assess changes in brain activation in response to water and saliva swallowing and during rest. Data were analysed (SPM8) at P

Original language	English
Pages (from-to)	1-10
Number of pages	10
Journal	NeuroImage
Volume	117
DOIs	https://doi.org/10.1016/j.neuroimage.2015.05.007
Publication status	Published - 15 Aug 2015

Keywords

Cortex
GABA
Neuroplasticity
Paired associative stimulation
Pharynx
Swallowing

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.neuroimage.2015.05.007

http://www.ncbi.nlm.nih.gov/pubmed/25976926

Cite this

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title = "fMRI and MRS measures of neuroplasticity in the pharyngeal motor cortex.",

abstract = "INTRODUCTION: Paired associative stimulation (PAS), is a novel non-invasive technique where two neural substrates are employed in a temporally coordinated manner in order to modulate cortico-motor excitability within the motor cortex (M1). In swallowing, combined pharyngeal electrical and transcranial-magnetic-stimulation induced beneficial neurophysiological and behavioural effects in healthy subjects and dysphagic stroke patients. Here, we aimed to investigate the whole-brain changes in neural activation during swallowing using functional magnetic resonance imaging (fMRI) following PAS application and in parallel assess associated GABA changes with magnetic resonance spectroscopy (MRS). METHODS: Healthy adults (n=11, 38±9years old) were randomised to receive real and sham PAS to the 'stronger' motor cortex pharyngeal representation, on 2 separate visits. Following PAS, event-related fMRI was performed to assess changes in brain activation in response to water and saliva swallowing and during rest. Data were analysed (SPM8) at P",

keywords = "Cortex, GABA, Neuroplasticity, Paired associative stimulation, Pharynx, Swallowing",

author = "Emilia Michou and Steve Williams and Rishma Vidyasagar and Darragh Downey and Satish Mistry and Edden, {Richard A E} and Shaheen Hamdy",

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T1 - fMRI and MRS measures of neuroplasticity in the pharyngeal motor cortex.

AU - Michou, Emilia

AU - Williams, Steve

AU - Vidyasagar, Rishma

AU - Downey, Darragh

AU - Mistry, Satish

AU - Edden, Richard A E

AU - Hamdy, Shaheen

N1 - P41 EB015909, NIBIB NIH HHS, United StatesR01 EB016089, NIBIB NIH HHS, United States

PY - 2015/8/15

Y1 - 2015/8/15

N2 - INTRODUCTION: Paired associative stimulation (PAS), is a novel non-invasive technique where two neural substrates are employed in a temporally coordinated manner in order to modulate cortico-motor excitability within the motor cortex (M1). In swallowing, combined pharyngeal electrical and transcranial-magnetic-stimulation induced beneficial neurophysiological and behavioural effects in healthy subjects and dysphagic stroke patients. Here, we aimed to investigate the whole-brain changes in neural activation during swallowing using functional magnetic resonance imaging (fMRI) following PAS application and in parallel assess associated GABA changes with magnetic resonance spectroscopy (MRS). METHODS: Healthy adults (n=11, 38±9years old) were randomised to receive real and sham PAS to the 'stronger' motor cortex pharyngeal representation, on 2 separate visits. Following PAS, event-related fMRI was performed to assess changes in brain activation in response to water and saliva swallowing and during rest. Data were analysed (SPM8) at P

AB - INTRODUCTION: Paired associative stimulation (PAS), is a novel non-invasive technique where two neural substrates are employed in a temporally coordinated manner in order to modulate cortico-motor excitability within the motor cortex (M1). In swallowing, combined pharyngeal electrical and transcranial-magnetic-stimulation induced beneficial neurophysiological and behavioural effects in healthy subjects and dysphagic stroke patients. Here, we aimed to investigate the whole-brain changes in neural activation during swallowing using functional magnetic resonance imaging (fMRI) following PAS application and in parallel assess associated GABA changes with magnetic resonance spectroscopy (MRS). METHODS: Healthy adults (n=11, 38±9years old) were randomised to receive real and sham PAS to the 'stronger' motor cortex pharyngeal representation, on 2 separate visits. Following PAS, event-related fMRI was performed to assess changes in brain activation in response to water and saliva swallowing and during rest. Data were analysed (SPM8) at P

KW - Cortex

KW - GABA

KW - Neuroplasticity

KW - Paired associative stimulation

KW - Pharynx

KW - Swallowing

U2 - 10.1016/j.neuroimage.2015.05.007

DO - 10.1016/j.neuroimage.2015.05.007

M3 - Article

C2 - 25976926

SN - 1095-9572

VL - 117

SP - 1

EP - 10

JO - NeuroImage

JF - NeuroImage

ER -

fMRI and MRS measures of neuroplasticity in the pharyngeal motor cortex.

Abstract

Keywords

UN SDGs

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