Folate-targeted non-viral DNA vectors for cancer gene therapy

Christopher M. Ward

    Research output: Contribution to journalArticlepeer-review


    The vitamin folic acid exhibits high affinity for the endocytosed, membrane-bound folate receptor. Conjugation of folic acid via its γ-carboxyl group to various macromolecules results in binding to, and endocytosis into, cells expressing the folate receptor. The folate receptor is overexpressed on a wide range of cancers, therefore fdic acid has been investigated as a targeting ligand for the specific delivery of therapeutic compounds to cancer cells. This review will introduce folate-targeting of macromolecules to cancer cells in vitro and in vivo, and discuss the accumulation of such compounds in non-target tissues in vivo. Folate-targeting of non-viral DNA vectors in vitro and in vivo will be discussed in detail, with particular emphasis on the recent advances in this field.
    Original languageEnglish
    Pages (from-to)182-187
    Number of pages5
    JournalCurrent Opinion in Molecular Therapeutics
    Issue number2
    Publication statusPublished - 2000


    • Cancer
    • DNA
    • Folate receptor
    • Targeting
    • Vector


    Dive into the research topics of 'Folate-targeted non-viral DNA vectors for cancer gene therapy'. Together they form a unique fingerprint.

    Cite this