Follicle-stimulating hormone receptor gene polymorphisms are not associated with ovarian reserve markers

Lamiya Mohiyiddeen; William G. Newman; Helen McBurney; Betselot Mulugeta; Stephen A. Roberts; Luciano G. Nardo

doi:10.1016/j.fertnstert.2011.12.040

Follicle-stimulating hormone receptor gene polymorphisms are not associated with ovarian reserve markers

Lamiya Mohiyiddeen, William G. Newman, Helen McBurney, Betselot Mulugeta, Stephen A. Roberts, Luciano G. Nardo

Research output: Contribution to journal › Article › peer-review

Abstract

Objective: To evaluate the association between variants in the FSHR receptor (FSHR) gene and current markers of ovarian reserve (antimüllerian hormone, antral follicle count, FSH). Design: Prospective observational study. Setting: Tertiary referral center for reproductive medicine. Patient(s): Women (n = 421) undergoing their first cycle of controlled ovarian stimulation for IVF. Intervention(s): Baseline pelvic ultrasound and blood tests were taken on day 2-3 of the cycle for assessment of baseline hormones and for DNA extraction. Genotypes for FSHR p.Asn680Ser and p.Thr307Ala variants were determined using TaqMan allelic discrimination assays. Main Outcome Measure(s): Association of FSHR single nucleotide polymorphisms with markers of ovarian reserve. Result(s): There was no evidence of any difference in basal FSH, antimüllerian hormone, or antral follicle count between the patients with different genotypes, with or without an adjustment for age or body mass index. Conclusion(s): No associations of FSHR genotypes with markers of ovarian reserve were detected in our cohort. © 2012 American Society for Reproductive Medicine, Published by Elsevier Inc.

Original language	English
Pages (from-to)	677-681
Number of pages	4
Journal	Fertility and Sterility
Volume	97
Issue number	3
DOIs	https://doi.org/10.1016/j.fertnstert.2011.12.040
Publication status	Published - Mar 2012

Keywords

antimüllerian hormone
antral follicle count
follicle-stimulating hormone
Ser680Asn
Single nucleotide polymorphism
Thr307Ala FSH receptor

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10.1016/j.fertnstert.2011.12.040

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title = "Follicle-stimulating hormone receptor gene polymorphisms are not associated with ovarian reserve markers",

abstract = "Objective: To evaluate the association between variants in the FSHR receptor (FSHR) gene and current markers of ovarian reserve (antim{\"u}llerian hormone, antral follicle count, FSH). Design: Prospective observational study. Setting: Tertiary referral center for reproductive medicine. Patient(s): Women (n = 421) undergoing their first cycle of controlled ovarian stimulation for IVF. Intervention(s): Baseline pelvic ultrasound and blood tests were taken on day 2-3 of the cycle for assessment of baseline hormones and for DNA extraction. Genotypes for FSHR p.Asn680Ser and p.Thr307Ala variants were determined using TaqMan allelic discrimination assays. Main Outcome Measure(s): Association of FSHR single nucleotide polymorphisms with markers of ovarian reserve. Result(s): There was no evidence of any difference in basal FSH, antim{\"u}llerian hormone, or antral follicle count between the patients with different genotypes, with or without an adjustment for age or body mass index. Conclusion(s): No associations of FSHR genotypes with markers of ovarian reserve were detected in our cohort. {\textcopyright} 2012 American Society for Reproductive Medicine, Published by Elsevier Inc.",

keywords = "antim{\"u}llerian hormone, antral follicle count, follicle-stimulating hormone, Ser680Asn, Single nucleotide polymorphism, Thr307Ala FSH receptor",

author = "Lamiya Mohiyiddeen and Newman, {William G.} and Helen McBurney and Betselot Mulugeta and Roberts, {Stephen A.} and Nardo, {Luciano G.}",

note = "major revision (actually pretty minor!) resub 7/10/11 accepted with minor changes 6/12/11 accepted 21/12/11 pub online 21/1/12 in print: March 2012",

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AU - Mohiyiddeen, Lamiya

AU - Newman, William G.

AU - McBurney, Helen

AU - Mulugeta, Betselot

AU - Roberts, Stephen A.

AU - Nardo, Luciano G.

N1 - major revision (actually pretty minor!) resub 7/10/11 accepted with minor changes 6/12/11 accepted 21/12/11 pub online 21/1/12 in print: March 2012

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N2 - Objective: To evaluate the association between variants in the FSHR receptor (FSHR) gene and current markers of ovarian reserve (antimüllerian hormone, antral follicle count, FSH). Design: Prospective observational study. Setting: Tertiary referral center for reproductive medicine. Patient(s): Women (n = 421) undergoing their first cycle of controlled ovarian stimulation for IVF. Intervention(s): Baseline pelvic ultrasound and blood tests were taken on day 2-3 of the cycle for assessment of baseline hormones and for DNA extraction. Genotypes for FSHR p.Asn680Ser and p.Thr307Ala variants were determined using TaqMan allelic discrimination assays. Main Outcome Measure(s): Association of FSHR single nucleotide polymorphisms with markers of ovarian reserve. Result(s): There was no evidence of any difference in basal FSH, antimüllerian hormone, or antral follicle count between the patients with different genotypes, with or without an adjustment for age or body mass index. Conclusion(s): No associations of FSHR genotypes with markers of ovarian reserve were detected in our cohort. © 2012 American Society for Reproductive Medicine, Published by Elsevier Inc.

AB - Objective: To evaluate the association between variants in the FSHR receptor (FSHR) gene and current markers of ovarian reserve (antimüllerian hormone, antral follicle count, FSH). Design: Prospective observational study. Setting: Tertiary referral center for reproductive medicine. Patient(s): Women (n = 421) undergoing their first cycle of controlled ovarian stimulation for IVF. Intervention(s): Baseline pelvic ultrasound and blood tests were taken on day 2-3 of the cycle for assessment of baseline hormones and for DNA extraction. Genotypes for FSHR p.Asn680Ser and p.Thr307Ala variants were determined using TaqMan allelic discrimination assays. Main Outcome Measure(s): Association of FSHR single nucleotide polymorphisms with markers of ovarian reserve. Result(s): There was no evidence of any difference in basal FSH, antimüllerian hormone, or antral follicle count between the patients with different genotypes, with or without an adjustment for age or body mass index. Conclusion(s): No associations of FSHR genotypes with markers of ovarian reserve were detected in our cohort. © 2012 American Society for Reproductive Medicine, Published by Elsevier Inc.

KW - antimüllerian hormone

KW - antral follicle count

KW - follicle-stimulating hormone

KW - Ser680Asn

KW - Single nucleotide polymorphism

KW - Thr307Ala FSH receptor

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DO - 10.1016/j.fertnstert.2011.12.040

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JO - Fertility and Sterility

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ER -

Follicle-stimulating hormone receptor gene polymorphisms are not associated with ovarian reserve markers

Abstract

Keywords

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