TY - JOUR
T1 - Force and the spindle: Mechanical cues in mitotic spindle orientation
AU - Nestor-Bergmann, Alexander
AU - Goddard, Georgina
AU - Woolner, Sarah
PY - 2014
Y1 - 2014
N2 - The mechanical environment of a cell has a profound effect on its behaviour, from dictating cell shape to driving the transcription of specific genes. Recent studies have demonstrated that mechanical forces play a key role in orienting the mitotic spindle, and therefore cell division, in both single cells and tissues. Whilst the molecular machinery that mediates the link between external force and the mitotic spindle remains largely unknown, it is becoming increasingly clear that this is a widely used mechanism which could prove vital for coordinating cell division orientation across tissues in a variety of contexts. © 2014.
AB - The mechanical environment of a cell has a profound effect on its behaviour, from dictating cell shape to driving the transcription of specific genes. Recent studies have demonstrated that mechanical forces play a key role in orienting the mitotic spindle, and therefore cell division, in both single cells and tissues. Whilst the molecular machinery that mediates the link between external force and the mitotic spindle remains largely unknown, it is becoming increasingly clear that this is a widely used mechanism which could prove vital for coordinating cell division orientation across tissues in a variety of contexts. © 2014.
U2 - 10.1016/j.semcdb.2014.07.008
DO - 10.1016/j.semcdb.2014.07.008
M3 - Article
SN - 1084-9521
JO - Seminars in Cell and Developmental Biology
JF - Seminars in Cell and Developmental Biology
ER -