Force and the spindle: Mechanical cues in mitotic spindle orientation

Alexander Nestor-Bergmann, Georgina Goddard, Sarah Woolner

    Research output: Contribution to journalArticlepeer-review


    The mechanical environment of a cell has a profound effect on its behaviour, from dictating cell shape to driving the transcription of specific genes. Recent studies have demonstrated that mechanical forces play a key role in orienting the mitotic spindle, and therefore cell division, in both single cells and tissues. Whilst the molecular machinery that mediates the link between external force and the mitotic spindle remains largely unknown, it is becoming increasingly clear that this is a widely used mechanism which could prove vital for coordinating cell division orientation across tissues in a variety of contexts. © 2014.
    Original languageEnglish
    JournalSeminars in Cell and Developmental Biology
    Publication statusPublished - 2014


    Dive into the research topics of 'Force and the spindle: Mechanical cues in mitotic spindle orientation'. Together they form a unique fingerprint.

    Cite this