Formation of C(sp(2))-Boronate Esters by Borylative Cyclization of Alkynes Using BCl3

Andrew J. Warner, James R. Lawson, Valerio Fasano, Michael J. Ingleson

    Research output: Contribution to journalArticlepeer-review

    Abstract

    BCl3 is an inexpensive electrophile which induces the borylative cyclization of a wide range of substituted alkynes to regioselectively form polycycles containing synthetically versatile C(sp2)boronate esters. It proceeds rapidly, with good yields and is compatible with a range of functional groups and substitution patterns. Intermolecular 1,2‐carboboration of alkynes is also achieved using BCl3 to generate trisubstituted vinyl boronate esters.
    Original languageEnglish
    Pages (from-to)11245-11249
    Number of pages5
    JournalANGEWANDTE CHEMIE-INTERNATIONAL EDITION
    Volume54
    Issue number38
    DOIs
    Publication statusPublished - 14 Sept 2015

    Keywords

    • alkynes
    • boron
    • cyclizations
    • heterocycles
    • synthetic methods

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