Forming patterns in development without morphogen gradients: scattered differentiation and sorting out.

Robert R. Kay, Christopher R L Thompson

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Few mechanisms provide alternatives to morphogen gradients for producing spatial patterns of cells in development. One possibility is based on the sorting out of cells that initially differentiate in a salt and pepper mixture and then physically move to create coherent tissues. Here, we describe the evidence suggesting this is the major mode of patterning in Dictyostelium. In addition, we discuss whether convergent evolution could have produced a conceptually similar mechanism in other organisms.
    Original languageEnglish
    Pages (from-to)a001503
    JournalCold Spring Harbor Perspectives in Biology
    Volume1
    Issue number6
    DOIs
    Publication statusPublished - Dec 2009

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