Free radicals and redox signalling in T-cells during chronic inflammation and ageing

Helen R. Griffiths, Christopher R. Dunston, Stuart J. Bennett, Melissa M. Grant, Darren C. Phillips, George D. Kitas

    Research output: Contribution to journalArticlepeer-review

    Abstract

    During chronic inflammation and ageing, the increase in oxidative stress in both intracellular and extracellular compartments is likely to influence local cell functions. Redox changes alter the T-cell proteome in a quantitative and qualitative manner, and post-translational modifications to surface and cytoplasmic proteins by increased reactive species can influence T-cell function. Previously, we have shown that RA (rheumatoid arthritis) T-cells exhibit reduced ROS (reactive oxygen species) production in response to extracellular stimulation compared with age-matched controls, and basal ROS levels [measured as DCF (2′,7′-dichlorofluorescein) fluorescence] are lower in RA T-cells. In contrast, exposing T-cells in vitro to different extracellular redox environments modulates intracellular signalling and enhances cytokine secretion. Together, these data suggest that a complex relationship exists between intra- and extra-cellular redox compartments which contribute to the T-cell phenotype. ©The Authors Journal compilation ©2011 Biochemical Society.
    Original languageEnglish
    Pages (from-to)1273-1278
    Number of pages5
    JournalBiochemical Society Transactions
    Volume39
    Issue number5
    DOIs
    Publication statusPublished - Oct 2011

    Keywords

    • Ageing
    • Glutathione
    • Inflammation
    • Reactive oxygen species (ROS)
    • Redox signalling
    • Regulatory T-cell (T reg cell)

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