Frequency and evolution of azole resistance in Aspergillus fumigatus associated with treatment failure

Susan Howard, Susan J. Howard, Dasa Cerar, Michael J. Anderson, Ahmed Albarrag, Matthew C. Fisher, Alessandro C. Pasqualotto, Michel Laverdiere, Maiken C. Arendrup, David S. Perlin, David W. Denning

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Azoles are the mainstay of oral therapy for aspergillosis. Azole resistance in Aspergillus has been reported infrequently. The first resistant isolate in Manchester, UK, was detected in 1999. In a clinical collection of 519 A. fumigatus isolates, the frequency of itraconazole resistance was 5%, a significant increase since 2004 (p
    Original languageEnglish
    Pages (from-to)1068-1076
    Number of pages8
    JournalEmerging infectious diseases
    Volume15
    Issue number7
    DOIs
    Publication statusPublished - Jul 2009

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