From amnesia to dementia: ERP studies of memory and language

Jason R. Taylor, John M. Olichney

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Cognitive event-related potential (ERP) studies of memory and language impairments in amnesia and Alzheimer's disease (AD) are reviewed. Well-circumscribed lesions of the medial temporal lobe (MTL) or diencephalon causing an amnestic syndrome, an inability to encode and retrieve episodic memories beyond the brief duration of working memory, appear to produce altered plasticity of the late positive P600 component, but usually spare P300 and N400 components. The neuropathology of AD affects MTL and extends to neocortical association areas, causing deficits of episodic and semantic memory. In AD dementia, the P300, N400, and P600 all commonly show abnormalities. ERP studies of individuals with mild cognitive impairment may reveal neurophysiological changes prior to the emergence of clinical deficits, which could advance the early detection and diagnosis of AD.
    Original languageEnglish
    Pages (from-to)8-17
    Number of pages9
    JournalClinical EEG and Neuroscience
    Volume38
    Issue number1
    Publication statusPublished - Jan 2007

    Keywords

    • Alzheimer's disease
    • Amnesia
    • Event-related potentials
    • LPC
    • Mild cognitive impairment
    • N400
    • P300
    • P600

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