From Particles to Powders: Digital Approaches to Understand Structure and Powder Flow of Inhaled Formulations

Parmesh Gajjar; Thai T H  Nguyen; Ioanna Danai Styliari; Vivian W. Barron; Timothy Burnett; Xizhong Chen; Simon D. Connell; James A. Elliott; Robert Hammond; F. M. Mahdi; Kevin Roberts; Philip Withers; Darragh Murnane

From Particles to Powders: Digital Approaches to Understand Structure and Powder Flow of Inhaled Formulations

Parmesh Gajjar, Thai T H Nguyen, Ioanna Danai Styliari, Vivian W. Barron, Timothy Burnett, Xizhong Chen, Simon D. Connell, James A. Elliott, Robert Hammond, F. M. Mahdi, Kevin Roberts, Philip Withers, Darragh Murnane

Materials Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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Abstract

The design of a successful inhaled formulation is a complex project that requires fine tuning of processes and properties to achieve optimal performance. In this work we attempt to provide a summary from the INFORM2020 project of an all-inclusive investigation of inhalation powder blends at various levels of scrutiny. X-Ray Microscopy (XRM) is used to characterize the microstructure and the microstructural changes induced by processing, ring shear tests are used to assess the flowability of the powders and in silico molecular modelling is used to predict the morphology and inter-particle interactions that are critical to efficiently designing superior future formulations. Using this holistic characterization approach to link particle properties to successful inhaled therapies, we hope future dry powder inhalation formulation projects will leave the realm of mysterious art and become firmly science based.

Original language	English
Title of host publication	Respiratory Drug Delivery Europe 2021
Publication status	Accepted/In press - 11 Apr 2021

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Gajjar RDD2021_INFORM FinalAccepted author manuscript, 3.8 MB

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title = "From Particles to Powders: Digital Approaches to Understand Structure and Powder Flow of Inhaled Formulations",

abstract = "The design of a successful inhaled formulation is a complex project that requires fine tuning of processes and properties to achieve optimal performance. In this work we attempt to provide a summary from the INFORM2020 project of an all-inclusive investigation of inhalation powder blends at various levels of scrutiny. X-Ray Microscopy (XRM) is used to characterize the microstructure and the microstructural changes induced by processing, ring shear tests are used to assess the flowability of the powders and in silico molecular modelling is used to predict the morphology and inter-particle interactions that are critical to efficiently designing superior future formulations. Using this holistic characterization approach to link particle properties to successful inhaled therapies, we hope future dry powder inhalation formulation projects will leave the realm of mysterious art and become firmly science based. ",

author = "Parmesh Gajjar and Nguyen, {Thai T H} and Styliari, {Ioanna Danai} and Barron, {Vivian W.} and Timothy Burnett and Xizhong Chen and Connell, {Simon D.} and Elliott, {James A.} and Robert Hammond and Mahdi, {F. M.} and Kevin Roberts and Philip Withers and Darragh Murnane",

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day = "11",

language = "English",

booktitle = "Respiratory Drug Delivery Europe 2021",

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T1 - From Particles to Powders: Digital Approaches to Understand Structure and Powder Flow of Inhaled Formulations

AU - Gajjar, Parmesh

AU - Nguyen, Thai T H

AU - Styliari, Ioanna Danai

AU - Barron, Vivian W.

AU - Burnett, Timothy

AU - Chen, Xizhong

AU - Connell, Simon D.

AU - Elliott, James A.

AU - Hammond, Robert

AU - Mahdi, F. M.

AU - Roberts, Kevin

AU - Withers, Philip

AU - Murnane, Darragh

PY - 2021/4/11

Y1 - 2021/4/11

N2 - The design of a successful inhaled formulation is a complex project that requires fine tuning of processes and properties to achieve optimal performance. In this work we attempt to provide a summary from the INFORM2020 project of an all-inclusive investigation of inhalation powder blends at various levels of scrutiny. X-Ray Microscopy (XRM) is used to characterize the microstructure and the microstructural changes induced by processing, ring shear tests are used to assess the flowability of the powders and in silico molecular modelling is used to predict the morphology and inter-particle interactions that are critical to efficiently designing superior future formulations. Using this holistic characterization approach to link particle properties to successful inhaled therapies, we hope future dry powder inhalation formulation projects will leave the realm of mysterious art and become firmly science based.

AB - The design of a successful inhaled formulation is a complex project that requires fine tuning of processes and properties to achieve optimal performance. In this work we attempt to provide a summary from the INFORM2020 project of an all-inclusive investigation of inhalation powder blends at various levels of scrutiny. X-Ray Microscopy (XRM) is used to characterize the microstructure and the microstructural changes induced by processing, ring shear tests are used to assess the flowability of the powders and in silico molecular modelling is used to predict the morphology and inter-particle interactions that are critical to efficiently designing superior future formulations. Using this holistic characterization approach to link particle properties to successful inhaled therapies, we hope future dry powder inhalation formulation projects will leave the realm of mysterious art and become firmly science based.

M3 - Conference contribution

BT - Respiratory Drug Delivery Europe 2021

ER -

From Particles to Powders: Digital Approaches to Understand Structure and Powder Flow of Inhaled Formulations

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