Abstract
Max-Planck-lnstitut fur Neurologische Forschung, Koln, Germany.Thirty-one patients with probable Alzheimer's disease (AD) according to NINCDS-ADRDA criteria were psychometrically tested with various frontal lobe tasks. The results were correlated with regional cerebral glucose metabolism (rCMRG1) as measured by positron emission tomography of 18F-2-fluoro-2-deoxy-D-glucose. RCMRG1 of frontal functional-anatomically defined regions was not linked to the performance seen in frontal lobe testing. The majority of the frontal lobe tasks showed a high correlation to severity of dementia that was related to rCMRG1 of the temporo-parietal cortex. There were high intercorrelations of frontal lobe test scores to other tests. Thus, these tasks seem to measure nonspecific cognitive changes in AD patients.PMID: 11011970 [PubMed - indexed for MEDLINE]
| Original language | English |
|---|---|
| Journal | Journal of Neuroscience |
| Volume | 1 |
| Publication status | Published - 2000 |