Function of histone deacetylase inhibitors in inflammation

Aleksander M. Grabiec, Paul P. Tak, Kris A. Reedquist

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    Histone deacetylases (HDACs) display multi-faceted roles in coordinating the interaction of intracel-lular signaling pathways with chromatin remodeling and transcription factor function to fnely specify gene alterations and maintenance of gene expression during cellular activation, proliferation, and differentiation. These processes, epigenetic and non-epigenetic, are critical to the development of both the adaptive and innate arms of the mammalian immune system, and the measured initiation and resolution of immune responses. Pharmacological modulators of HDAC activity have demonstrated uniformly potent anti-inflammatory effects in experimental animal models of these diseases, in relevant immune and stromal cell populations from patients, as well as initial successes in the clinic. Recent studies have identified key roles for specific HDACs in regulating immune function, as well as alterations in HDAC expression and function in a number of immune-mediated inflammatory diseases (IMIDs), which may contribute to pathology in these diseases. Here, we review recent advances in our understanding of HDAC function in the immune system, their contribution to IMIDs, and the therapeutic potential of altering HDAC activity in IMIDs. © 2011 by Begell House, Inc.
    Original languageEnglish
    Pages (from-to)233-263
    Number of pages30
    JournalCritical Reviews in Immunology
    Issue number3
    Publication statusPublished - 2011


    • Acetylation
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    • Hdac
    • Rheumatoid arthritis
    • Sirtuin
    • Systemic onset juvenile idiopathic arthritis


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