Functional analysis of a mitochondrial phosphopantetheinyl transferase (PPTase) gene pptB in Aspergillus fumigatus

Gethin Allen; Mike Bromley; Sarah J. Kaye; David Keszenman-Pereyra; Tiago D. Zucchi; Jaqueline Price; Mike Birch; Jason D. Oliver; Geoffrey Turner

doi:10.1016/j.fgb.2010.12.006

Functional analysis of a mitochondrial phosphopantetheinyl transferase (PPTase) gene pptB in Aspergillus fumigatus

Gethin Allen, Mike Bromley, Sarah J. Kaye, David Keszenman-Pereyra, Tiago D. Zucchi, Jaqueline Price, Mike Birch, Jason D. Oliver, Geoffrey Turner

Research output: Contribution to journal › Article › peer-review

Abstract

The mitochondrial phosphopantetheinyl transferase gene pptB of the opportunistic pathogen Aspergillus fumigatus has been identified and characterised. Unlike pptA, which is required for lysine biosynthesis, secondary metabolism, and iron assimilation, pptB is essential for viability. PptB is located in the mitochondria. In vitro expression of pptA and pptB has shown that PptB is specific for the mitochondrial acyl carrier protein AcpA. © 2010 Elsevier Inc.

Original language	English
Pages (from-to)	456-464
Number of pages	8
Journal	Fungal Genetics and Biology
Volume	48
Issue number	4
DOIs	https://doi.org/10.1016/j.fgb.2010.12.006
Publication status	Published - Apr 2011

Keywords

Aspergillus fumigatus
Essential genes
NpgA
Phosphopantetheinyl transferase
PptA
PptB
Respiration
Siderophore

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10.1016/j.fgb.2010.12.006

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title = "Functional analysis of a mitochondrial phosphopantetheinyl transferase (PPTase) gene pptB in Aspergillus fumigatus",

abstract = "The mitochondrial phosphopantetheinyl transferase gene pptB of the opportunistic pathogen Aspergillus fumigatus has been identified and characterised. Unlike pptA, which is required for lysine biosynthesis, secondary metabolism, and iron assimilation, pptB is essential for viability. PptB is located in the mitochondria. In vitro expression of pptA and pptB has shown that PptB is specific for the mitochondrial acyl carrier protein AcpA. {\textcopyright} 2010 Elsevier Inc.",

keywords = "Aspergillus fumigatus, Essential genes, NpgA, Phosphopantetheinyl transferase, PptA, PptB, Respiration, Siderophore",

author = "Gethin Allen and Mike Bromley and Kaye, {Sarah J.} and David Keszenman-Pereyra and Zucchi, {Tiago D.} and Jaqueline Price and Mike Birch and Oliver, {Jason D.} and Geoffrey Turner",

year = "2011",

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doi = "10.1016/j.fgb.2010.12.006",

language = "English",

volume = "48",

pages = "456--464",

journal = "Fungal Genetics and Biology",

issn = "1087-1845",

publisher = "Elsevier BV",

number = "4",

}

TY - JOUR

T1 - Functional analysis of a mitochondrial phosphopantetheinyl transferase (PPTase) gene pptB in Aspergillus fumigatus

AU - Allen, Gethin

AU - Bromley, Mike

AU - Kaye, Sarah J.

AU - Keszenman-Pereyra, David

AU - Zucchi, Tiago D.

AU - Price, Jaqueline

AU - Birch, Mike

AU - Oliver, Jason D.

AU - Turner, Geoffrey

PY - 2011/4

Y1 - 2011/4

N2 - The mitochondrial phosphopantetheinyl transferase gene pptB of the opportunistic pathogen Aspergillus fumigatus has been identified and characterised. Unlike pptA, which is required for lysine biosynthesis, secondary metabolism, and iron assimilation, pptB is essential for viability. PptB is located in the mitochondria. In vitro expression of pptA and pptB has shown that PptB is specific for the mitochondrial acyl carrier protein AcpA. © 2010 Elsevier Inc.

AB - The mitochondrial phosphopantetheinyl transferase gene pptB of the opportunistic pathogen Aspergillus fumigatus has been identified and characterised. Unlike pptA, which is required for lysine biosynthesis, secondary metabolism, and iron assimilation, pptB is essential for viability. PptB is located in the mitochondria. In vitro expression of pptA and pptB has shown that PptB is specific for the mitochondrial acyl carrier protein AcpA. © 2010 Elsevier Inc.

KW - Aspergillus fumigatus

KW - Essential genes

KW - NpgA

KW - Phosphopantetheinyl transferase

KW - PptA

KW - PptB

KW - Respiration

KW - Siderophore

U2 - 10.1016/j.fgb.2010.12.006

DO - 10.1016/j.fgb.2010.12.006

M3 - Article

C2 - 21195204

SN - 1087-1845

VL - 48

SP - 456

EP - 464

JO - Fungal Genetics and Biology

JF - Fungal Genetics and Biology

IS - 4

ER -

Functional analysis of a mitochondrial phosphopantetheinyl transferase (PPTase) gene pptB in Aspergillus fumigatus

Abstract

Keywords

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