Functional and phenotypic heterogeneity of group 3 innate lymphoid cells

Felipe Melo Gonzalez, Matthew Hepworth

Research output: Contribution to journalArticlepeer-review


Group 3 innate lymphoid cells (ILC3), defined by expression of the transcription factor retinoid-related orphan receptor γt, play key roles in the regulation of inflammation and immunity in the gastrointestinal tract and associated lymphoid tissues. ILC3 consist largely of two major subsets, NCR+ ILC3 and LTi-like ILC3, but also demonstrate significant plasticity and heterogeneity. Recent advances have begun to dissect the relationship between ILC3 subsets and to define distinct functional states within the intestinal tissue microenvironment. In this review we discuss the ever-expanding roles of ILC3 in the context of intestinal homeostasis, infection and inflammation – with a focus on comparing and contrasting the relative contributions of ILC3 subsets.
Original languageEnglish
Pages (from-to)265-275
Number of pages11
Issue number3
Early online date3 Jan 2017
Publication statusPublished - 3 Feb 2017


  • Innate lymphoid cell
  • ILC3
  • LTi
  • mucosal immunology


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