Functional evidence that the principal DNA replication origin of the Streptomyces coelicolor chromosome is close to the dnaA-gyrB region

M. S. Musialowski, F. Flett, G. B. Scott, G. Hobbs, C. P. Smith, S. G. Oliver

    Research output: Contribution to journalArticlepeer-review

    Abstract

    The degree of overrepresentation of selected chromosomal genes in rapidly growing cultures of Streptomyces coelicolor was assessed by quantitative DNA hybridization analysis. The results are consistent with the hypothesis that the principal origin of replication is close to the dnaA-gyrB region, in the center of the linear chromosome, and that replication proceeds bidirectionally.
    Original languageEnglish
    Pages (from-to)5123-5125
    Number of pages2
    JournalJournal of Bacteriology
    Volume176
    Issue number16
    Publication statusPublished - 1994

    Research Beacons, Institutes and Platforms

    • Manchester Institute of Biotechnology

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