Functional gene group analysis indicates no role for heterotrimeric G proteins in cognitive ability

W. David Hill; Christiaan De Leeuw; Gail Davies; David Cherry McLachlan Liewald; Anthony Payton; Leone C A Craig; Lawrence J. Whalley; Mike Horan; William Ollier; John M. Starr; Neil Pendleton; Danielle Posthuma; Timothy C. Bates; Ian J. Deary

doi:10.1371/journal.pone.0091690

Functional gene group analysis indicates no role for heterotrimeric G proteins in cognitive ability

W. David Hill, Christiaan De Leeuw, Gail Davies, David Cherry McLachlan Liewald, Anthony Payton, Leone C A Craig, Lawrence J. Whalley, Mike Horan, William Ollier, John M. Starr, Neil Pendleton, Danielle Posthuma, Timothy C. Bates, Ian J. Deary

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Abstract

Previous functional gene group analyses implicated common single nucleotide polymorphisms (SNPs) in heterotrimeric G protein coding genes as being associated with differences in human intelligence. Here, we sought to replicate this finding using five independent cohorts of older adults including current IQ and childhood IQ, and using both gene- and SNP-based analytic strategies. No significant associations were found between variation in heterotrimeric G protein genes and intelligence in any cohort at either of the two time points. These results indicate that, whereas G protein systems are important in cognition, common genetic variation in these genes is unlikely to be a substantial influence on human intelligence differences. © 2014 Hill et al.

Original language	English
Article number	e91690
Journal	PLoS ONE
Volume	9
Issue number	3
DOIs	https://doi.org/10.1371/journal.pone.0091690
Publication status	Published - 13 Mar 2014

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Hill, W. D., De Leeuw, C., Davies, G., Liewald, D. C. M., Payton, A., Craig, L. C. A., Whalley, L. J., Horan, M., Ollier, W., Starr, J. M., Pendleton, N., Posthuma, D., Bates, T. C., & Deary, I. J. (2014). Functional gene group analysis indicates no role for heterotrimeric G proteins in cognitive ability. PLoS ONE, 9(3), Article e91690. https://doi.org/10.1371/journal.pone.0091690

@article{61c16c34435b4523ae86d4380c740995,

title = "Functional gene group analysis indicates no role for heterotrimeric G proteins in cognitive ability",

abstract = "Previous functional gene group analyses implicated common single nucleotide polymorphisms (SNPs) in heterotrimeric G protein coding genes as being associated with differences in human intelligence. Here, we sought to replicate this finding using five independent cohorts of older adults including current IQ and childhood IQ, and using both gene- and SNP-based analytic strategies. No significant associations were found between variation in heterotrimeric G protein genes and intelligence in any cohort at either of the two time points. These results indicate that, whereas G protein systems are important in cognition, common genetic variation in these genes is unlikely to be a substantial influence on human intelligence differences. {\textcopyright} 2014 Hill et al.",

author = "Hill, {W. David} and {De Leeuw}, Christiaan and Gail Davies and Liewald, {David Cherry McLachlan} and Anthony Payton and Craig, {Leone C A} and Whalley, {Lawrence J.} and Mike Horan and William Ollier and Starr, {John M.} and Neil Pendleton and Danielle Posthuma and Bates, {Timothy C.} and Deary, {Ian J.}",

year = "2014",

month = mar,

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doi = "10.1371/journal.pone.0091690",

language = "English",

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AU - Hill, W. David

AU - De Leeuw, Christiaan

AU - Davies, Gail

AU - Liewald, David Cherry McLachlan

AU - Payton, Anthony

AU - Craig, Leone C A

AU - Whalley, Lawrence J.

AU - Horan, Mike

AU - Ollier, William

AU - Starr, John M.

AU - Pendleton, Neil

AU - Posthuma, Danielle

AU - Bates, Timothy C.

AU - Deary, Ian J.

PY - 2014/3/13

Y1 - 2014/3/13

N2 - Previous functional gene group analyses implicated common single nucleotide polymorphisms (SNPs) in heterotrimeric G protein coding genes as being associated with differences in human intelligence. Here, we sought to replicate this finding using five independent cohorts of older adults including current IQ and childhood IQ, and using both gene- and SNP-based analytic strategies. No significant associations were found between variation in heterotrimeric G protein genes and intelligence in any cohort at either of the two time points. These results indicate that, whereas G protein systems are important in cognition, common genetic variation in these genes is unlikely to be a substantial influence on human intelligence differences. © 2014 Hill et al.

AB - Previous functional gene group analyses implicated common single nucleotide polymorphisms (SNPs) in heterotrimeric G protein coding genes as being associated with differences in human intelligence. Here, we sought to replicate this finding using five independent cohorts of older adults including current IQ and childhood IQ, and using both gene- and SNP-based analytic strategies. No significant associations were found between variation in heterotrimeric G protein genes and intelligence in any cohort at either of the two time points. These results indicate that, whereas G protein systems are important in cognition, common genetic variation in these genes is unlikely to be a substantial influence on human intelligence differences. © 2014 Hill et al.

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DO - 10.1371/journal.pone.0091690

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VL - 9

JO - PLoS ONE

JF - PLoS ONE

IS - 3

M1 - e91690

ER -

Functional gene group analysis indicates no role for heterotrimeric G proteins in cognitive ability

Abstract

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