Functional implications of hippocampal degeneration in early Alzheimer's disease: A combined DTI and PET study

Igor Yakushev; Matthias Schreckenberger; Matthias J. Müller; Ingrid Schermuly; Paul Cumming; Peter Stoeter; Alex Gerhard; Andreas Fellgiebel

doi:10.1007/s00259-011-1882-1

Functional implications of hippocampal degeneration in early Alzheimer's disease: A combined DTI and PET study

Igor Yakushev, Matthias Schreckenberger, Matthias J. Müller, Ingrid Schermuly, Paul Cumming, Peter Stoeter, Alex Gerhard, Andreas Fellgiebel

Research output: Contribution to journal › Article › peer-review

Abstract

Purpose: Hypometabolism of the posterior cingulate cortex (PCC) in early Alzheimer's disease (AD) is thought to arise in part due to AD-specific neuronal damage to the hippocampal formation. Here, we explored the association between microstructural alterations within the hippocampus and whole-brain glucose metabolism in subjects with AD, also in relation to episodic memory impairment. Methods: Twenty patients with early AD (Mini-Mental State Examination 25.7±1.7) were studied with [ 18F]fluorodeoxyglucose (FDG) positron emission tomography and diffusion tensor imaging. Episodic memory performance was assessed using the free delayed verbal recall task (DVR). Voxel-wise relative FDG uptake was correlated to diffusivity indices of the hippocampus, followed by extraction of FDG uptake values from significant clusters. Linear regression analysis was performed to test for unique contributions of diffusivity and metabolic indices in the prediction of memory function. Results: Diffusivity in the left anterior hippocampus negatively correlated with FDG uptake primarily in the left anterior hippocampus, parahippocampal gyrus and the PCC (p

Original language	English
Pages (from-to)	2219-2227
Number of pages	8
Journal	European Journal of Nuclear Medicine and Molecular Imaging
Volume	38
Issue number	12
DOIs	https://doi.org/10.1007/s00259-011-1882-1
Publication status	Published - Dec 2011

Keywords

Dementia
Diffusion tensor imaging
Episodic memory
Mild cognitive impairment
Positron emission tomography
Posterior cingulate

Access to Document

10.1007/s00259-011-1882-1

Cite this

@article{dfafc93463e5476aa044293a7427b68a,

title = "Functional implications of hippocampal degeneration in early Alzheimer's disease: A combined DTI and PET study",

abstract = "Purpose: Hypometabolism of the posterior cingulate cortex (PCC) in early Alzheimer's disease (AD) is thought to arise in part due to AD-specific neuronal damage to the hippocampal formation. Here, we explored the association between microstructural alterations within the hippocampus and whole-brain glucose metabolism in subjects with AD, also in relation to episodic memory impairment. Methods: Twenty patients with early AD (Mini-Mental State Examination 25.7±1.7) were studied with [ 18F]fluorodeoxyglucose (FDG) positron emission tomography and diffusion tensor imaging. Episodic memory performance was assessed using the free delayed verbal recall task (DVR). Voxel-wise relative FDG uptake was correlated to diffusivity indices of the hippocampus, followed by extraction of FDG uptake values from significant clusters. Linear regression analysis was performed to test for unique contributions of diffusivity and metabolic indices in the prediction of memory function. Results: Diffusivity in the left anterior hippocampus negatively correlated with FDG uptake primarily in the left anterior hippocampus, parahippocampal gyrus and the PCC (p",

keywords = "Dementia, Diffusion tensor imaging, Episodic memory, Mild cognitive impairment, Positron emission tomography, Posterior cingulate",

author = "Igor Yakushev and Matthias Schreckenberger and M{\"u}ller, {Matthias J.} and Ingrid Schermuly and Paul Cumming and Peter Stoeter and Alex Gerhard and Andreas Fellgiebel",

year = "2011",

month = dec,

doi = "10.1007/s00259-011-1882-1",

language = "English",

volume = "38",

pages = "2219--2227",

journal = "European Journal of Nuclear Medicine and Molecular Imaging",

issn = "1619-7070",

publisher = "Springer Nature",

number = "12",

}

TY - JOUR

T1 - Functional implications of hippocampal degeneration in early Alzheimer's disease: A combined DTI and PET study

AU - Yakushev, Igor

AU - Schreckenberger, Matthias

AU - Müller, Matthias J.

AU - Schermuly, Ingrid

AU - Cumming, Paul

AU - Stoeter, Peter

AU - Gerhard, Alex

AU - Fellgiebel, Andreas

PY - 2011/12

Y1 - 2011/12

N2 - Purpose: Hypometabolism of the posterior cingulate cortex (PCC) in early Alzheimer's disease (AD) is thought to arise in part due to AD-specific neuronal damage to the hippocampal formation. Here, we explored the association between microstructural alterations within the hippocampus and whole-brain glucose metabolism in subjects with AD, also in relation to episodic memory impairment. Methods: Twenty patients with early AD (Mini-Mental State Examination 25.7±1.7) were studied with [ 18F]fluorodeoxyglucose (FDG) positron emission tomography and diffusion tensor imaging. Episodic memory performance was assessed using the free delayed verbal recall task (DVR). Voxel-wise relative FDG uptake was correlated to diffusivity indices of the hippocampus, followed by extraction of FDG uptake values from significant clusters. Linear regression analysis was performed to test for unique contributions of diffusivity and metabolic indices in the prediction of memory function. Results: Diffusivity in the left anterior hippocampus negatively correlated with FDG uptake primarily in the left anterior hippocampus, parahippocampal gyrus and the PCC (p

AB - Purpose: Hypometabolism of the posterior cingulate cortex (PCC) in early Alzheimer's disease (AD) is thought to arise in part due to AD-specific neuronal damage to the hippocampal formation. Here, we explored the association between microstructural alterations within the hippocampus and whole-brain glucose metabolism in subjects with AD, also in relation to episodic memory impairment. Methods: Twenty patients with early AD (Mini-Mental State Examination 25.7±1.7) were studied with [ 18F]fluorodeoxyglucose (FDG) positron emission tomography and diffusion tensor imaging. Episodic memory performance was assessed using the free delayed verbal recall task (DVR). Voxel-wise relative FDG uptake was correlated to diffusivity indices of the hippocampus, followed by extraction of FDG uptake values from significant clusters. Linear regression analysis was performed to test for unique contributions of diffusivity and metabolic indices in the prediction of memory function. Results: Diffusivity in the left anterior hippocampus negatively correlated with FDG uptake primarily in the left anterior hippocampus, parahippocampal gyrus and the PCC (p

KW - Dementia

KW - Diffusion tensor imaging

KW - Episodic memory

KW - Mild cognitive impairment

KW - Positron emission tomography

KW - Posterior cingulate

U2 - 10.1007/s00259-011-1882-1

DO - 10.1007/s00259-011-1882-1

M3 - Article

SN - 1619-7070

VL - 38

SP - 2219

EP - 2227

JO - European Journal of Nuclear Medicine and Molecular Imaging

JF - European Journal of Nuclear Medicine and Molecular Imaging

IS - 12

ER -

Functional implications of hippocampal degeneration in early Alzheimer's disease: A combined DTI and PET study

Abstract

Keywords

Access to Document

Fingerprint

Cite this