Functionalised collagen spheres reduce H2O2 mediated apoptosis by scavenging overexpressed ROS

C. Tapeinos; A. Larrañaga; J.-R. Sarasua; A. Pandit

doi:10.1016/j.nano.2017.03.022

Functionalised collagen spheres reduce H₂O₂ mediated apoptosis by scavenging overexpressed ROS

C. Tapeinos, A. Larrañaga, J.-R. Sarasua, A. Pandit

Pharmacy

Research output: Contribution to journal › Article › peer-review

Abstract

Excess reactive oxygen species (ROS) has been implicated in numerous diseases including cancer, cardiovascular and neurodegenerative diseases. Overexpression of ROS can lead to oxidative stress and subsequently to H₂O₂-mediated cell apoptosis. In this study, it was demonstrated that biodegradable PLGA microspheres coated with collagen type I and decorated with MnO₂ nanoparticles acted as ROS scavengers controlling the H₂O₂-mediated apoptosis of cells undergoing oxidative stress. The results showed that the functionalized collagen spheres can protect cells even under very harsh conditions of oxidative stress.

Original language	English
Pages (from-to)	2397-2405
Number of pages	9
Journal	Nanomedicine: Nanotechnology, Biology, and Medicine
Volume	14
Issue number	7
DOIs	https://doi.org/10.1016/j.nano.2017.03.022
Publication status	Published - Oct 2018

Keywords

PLGA
collagen microspheres
ROS scavengers
MnO2
apoptosis
oxidative stress

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.nano.2017.03.022

Cite this

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title = "Functionalised collagen spheres reduce H2O2 mediated apoptosis by scavenging overexpressed ROS",

abstract = "Excess reactive oxygen species (ROS) has been implicated in numerous diseases including cancer, cardiovascular and neurodegenerative diseases. Overexpression of ROS can lead to oxidative stress and subsequently to H2O2-mediated cell apoptosis. In this study, it was demonstrated that biodegradable PLGA microspheres coated with collagen type I and decorated with MnO2 nanoparticles acted as ROS scavengers controlling the H2O2-mediated apoptosis of cells undergoing oxidative stress. The results showed that the functionalized collagen spheres can protect cells even under very harsh conditions of oxidative stress.",

keywords = "PLGA, collagen microspheres, ROS scavengers, MnO2, apoptosis, oxidative stress",

author = "C. Tapeinos and A. Larra{\~n}aga and J.-R. Sarasua and A. Pandit",

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AU - Tapeinos, C.

AU - Larrañaga, A.

AU - Sarasua, J.-R.

AU - Pandit, A.

PY - 2018/10

Y1 - 2018/10

N2 - Excess reactive oxygen species (ROS) has been implicated in numerous diseases including cancer, cardiovascular and neurodegenerative diseases. Overexpression of ROS can lead to oxidative stress and subsequently to H2O2-mediated cell apoptosis. In this study, it was demonstrated that biodegradable PLGA microspheres coated with collagen type I and decorated with MnO2 nanoparticles acted as ROS scavengers controlling the H2O2-mediated apoptosis of cells undergoing oxidative stress. The results showed that the functionalized collagen spheres can protect cells even under very harsh conditions of oxidative stress.

AB - Excess reactive oxygen species (ROS) has been implicated in numerous diseases including cancer, cardiovascular and neurodegenerative diseases. Overexpression of ROS can lead to oxidative stress and subsequently to H2O2-mediated cell apoptosis. In this study, it was demonstrated that biodegradable PLGA microspheres coated with collagen type I and decorated with MnO2 nanoparticles acted as ROS scavengers controlling the H2O2-mediated apoptosis of cells undergoing oxidative stress. The results showed that the functionalized collagen spheres can protect cells even under very harsh conditions of oxidative stress.

KW - PLGA

KW - collagen microspheres

KW - ROS scavengers

KW - MnO2

KW - apoptosis

KW - oxidative stress

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JO - Nanomedicine: Nanotechnology, Biology, and Medicine

JF - Nanomedicine: Nanotechnology, Biology, and Medicine

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