Functionalized carbon nanotubes for plasmid DNA gene delivery

D. Pantarotto; R Singh; D McCarthy; M. Erhardt; J.P. Briand; M Prato; Kostas Kostarelos; A Bianco

Functionalized carbon nanotubes for plasmid DNA gene delivery

D. Pantarotto, R Singh, D McCarthy, M. Erhardt, J.P. Briand, M Prato, Kostas Kostarelos, A Bianco

Pharmacy

Research output: Contribution to journal › Article › peer-review

Abstract

Genetic vaccination and gene therapy research could benefit from the application of carbon nanotubes. Functionalized, positively charged, water-soluble carbon nanotubes are able to penetrate into cells (see figure) and can transport plasmid DNA by formation of noncovalent DNA-nanotube complexes. Such nanotubes can be used as novel nonviral delivery systems for gene transfer.

Original language	English
Pages (from-to)	5242-6
Journal	Angewandte Chemie - International Edition
Volume	43
Issue number	39
Publication status	Published - 2004

Cite this

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title = "Functionalized carbon nanotubes for plasmid DNA gene delivery",

abstract = "Genetic vaccination and gene therapy research could benefit from the application of carbon nanotubes. Functionalized, positively charged, water-soluble carbon nanotubes are able to penetrate into cells (see figure) and can transport plasmid DNA by formation of noncovalent DNA-nanotube complexes. Such nanotubes can be used as novel nonviral delivery systems for gene transfer.",

author = "D. Pantarotto and R Singh and D McCarthy and M. Erhardt and J.P. Briand and M Prato and Kostas Kostarelos and A Bianco",

year = "2004",

language = "English",

volume = "43",

pages = "5242--6",

journal = "Angewandte Chemie - International Edition",

issn = "1433-7851",

publisher = "John Wiley & Sons Ltd",

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TY - JOUR

T1 - Functionalized carbon nanotubes for plasmid DNA gene delivery

AU - Pantarotto, D.

AU - Singh, R

AU - McCarthy, D

AU - Erhardt, M.

AU - Briand, J.P.

AU - Prato, M

AU - Kostarelos, Kostas

AU - Bianco, A

PY - 2004

Y1 - 2004

N2 - Genetic vaccination and gene therapy research could benefit from the application of carbon nanotubes. Functionalized, positively charged, water-soluble carbon nanotubes are able to penetrate into cells (see figure) and can transport plasmid DNA by formation of noncovalent DNA-nanotube complexes. Such nanotubes can be used as novel nonviral delivery systems for gene transfer.

AB - Genetic vaccination and gene therapy research could benefit from the application of carbon nanotubes. Functionalized, positively charged, water-soluble carbon nanotubes are able to penetrate into cells (see figure) and can transport plasmid DNA by formation of noncovalent DNA-nanotube complexes. Such nanotubes can be used as novel nonviral delivery systems for gene transfer.

M3 - Article

SN - 1433-7851

VL - 43

SP - 5242

EP - 5246

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 39

ER -

Functionalized carbon nanotubes for plasmid DNA gene delivery

Abstract

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